The Registry of Toxic Effects of Chemical Substances

Methane, dichlorofluoro -

RTECS #: PA8400000

CAS #: 75-43-4

UPDATE: November 2004 MW: 102.92 MF: CHCl2F


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. REPRODUCTIVE EFFECTS DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. Algofrene type 5
  2. Arcton 7
  3. CFC - 21
  4. Dichlorofluoromethane
  5. Dichlorofluoromethane (ACGIH)
  6. Dichloromonofluoromethane (OSHA)
  7. Dwuchlorofluorometan (Polish)
  1. FC - 21
  2. Fluorocarbon 21
  3. Fluorodichloromethane
  4. Freon 21
  5. Genetron 21
  6. Racon 21
  7. Refrigerant 21


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published toxic concentration: 1 pph/6 hour (6-15 day pregnant) Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea) TXAPA9 45,293,1978
inhalation
rat 		lowest published toxic concentration: 30 mg/m3 (1-22 day pregnant) Reproductive: Effects on embryo or fetus: Fetal death VCVGH* -,614,1990
inhalation
rat 		lowest published toxic concentration: 100 mg/m3 (1-22 day pregnant) Reproductive: Effects on embryo or fetus: Extra embryonic structures (e.g., placenta, umbilical cord)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Effects on embryo or fetus: Fetal death 		VCVGH* -,614,1990


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
dog 		lowest published toxic concentration: 1 pph/10 minute Behavioral: Excitement

Cardiac: EKG changes not diagnostic of above

Kidney, Ureter, and Bladder: Incontinence 		EPASR* #86-890000758
inhalation
guinea pig 		lowest published lethal concentration: 10 pph/1 hour N/R FLCRAP 1,197,1967
inhalation
guinea pig 		lowest published lethal concentration: 260,400 mg/m3/5 minute N/R VCVGH* -,614,1990
inhalation
mouse 		lethal concentration (50 percent kill): >800 gm/m3/2 hour Behavioral: Tremor

Behavioral: Ataxia

Lung, Thorax, or Respiration: Other changes 		GTPZAB 20(11),38,1976
inhalation
mouse 		lowest published toxic concentration: 868,000 mg/m3 Behavioral: Convulsions or effect on seizure threshold

Gastrointestinal: Nausea or vomiting 		VCVGH* -,614,1990
inhalation
mouse 		lethal concentration (50 percent kill): 800,000 mg/m3/4 hour N/R VCVGH* -,614,1990
inhalation
rat 		lethal concentration (50 percent kill): 49,900 ppm/4 hour N/R 85INA8 5,187,1986


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
cat 		lowest published toxic concentration: 1 pph/3.5 hour/4 week- intermittent Liver: Hepatitis (hepatocellular necrosis), zonal

Liver: Fatty liver degeneration 		ZAARAM 21,149,1971
inhalation
dog 		lowest published toxic concentration: 1 pph/3.5 hour/4 week- intermittent Liver: Hepatitis (hepatocellular necrosis), zonal

Liver: Fatty liver degeneration 		ZAARAM 21,149,1971
inhalation
dog 		lowest published toxic concentration: 5,000 ppm/6 hour/13 week- intermittent Liver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		NTIS** OTS0520832
inhalation
guinea pig 		lowest published toxic concentration: 1 pph/3.5 hour/4 week- intermittent Liver: Hepatitis (hepatocellular necrosis), zonal

Liver: Fatty liver degeneration

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		ZAARAM 21,149,1971
inhalation
rat 		lowest published toxic concentration: 1 pph/6 hour/2 week- intermittent Liver: Other changes TXAPA9 41(1),199,1977
inhalation
rat 		lowest published toxic concentration: 1,000 ppm/6 hour/90 day- intermittent Skin and Appendages: Other: Hair

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		TXAPA9 41(1),200,1977


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 10 ppm DTLVS* TLV/BEI,2003
TOXICOLOGY REVIEW
FAZMAE 18,365,1974


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 1000 ppm (4200 mg/m3) DTLVS* 3,81,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 1000 ppm (4200 mg/m3) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 1000 ppm (4200 mg/m3) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 1000 ppm (4200 mg/m3) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 1000 ppm (4200 mg/m3) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 10 ppm (40 mg/m3), JAN1993
Occupational Exposure Limit - AUSTRIA MAK 10 ppm (45 mg/m3), JAN1999
Occupational Exposure Limit - BELGIUM time-weighted average 10 ppm (42 mg/m3), JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 10 ppm (40 mg/m3), JAN1999
Occupational Exposure Limit - FINLAND time-weighted average 10 ppm (40 mg/m3), short term exposure limit 20 ppm (80 mg/m3), JAN1999
Occupational Exposure Limit - FRANCE VME 10 ppm (40 mg/m3), JAN1999
Occupational Exposure Limit - GERMANY MAK 10 ppm (45 mg/m3), JAN1999
Occupational Exposure Limit - HUNGARY short term exposure limit 40 mg/m3, JAN1993
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 43 mg/m3, 2003
Occupational Exposure Limit - NORWAY time-weighted average 10 ppm (42 mg/m3), JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 1000 ppm (4200 mg/m3), JAN1993
Occupational Exposure Limit - POLAND MAC(time-weighted average) 40 mg/m3, MAC(short term exposure limit) 200 mg/m3, JAN1999
Occupational Exposure Limit - SWITZERLAND MAK- week 10 ppm (40 mg/m3), KZG- week 20 ppm (80 mg/m3), JAN1999
Occupational Exposure Limit - TURKEY time-weighted average 1000 ppm (4200 mg/m3), JAN1993
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 10 ppm (43 mg/m3), SEP2000
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 10 ppm
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 10 ppm


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO DICHLOROMONOFLUOROMETHANE-air 10 hour time-weighted average 10 ppm NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 24235;
Number of Industries 44;
Total Number of Facilities 4,131;
Number of Occupations 56;
Total Number of Employees Exposed 43,521
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 24235;
Number of Industries 8;
Total Number of Facilities 935;
Number of Occupations 13;
Total Number of Employees Exposed 12,182;
Total Number of Female Employees Exposed 1,640


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Dichlorofluoromethane, 2516


REFERENCES:

CODEN
REFERENCE
85INA8 "Documentation of the Threshold Limit Values and Biological Exposure Indices," 5th ed., Cincinnati, OH, American Conference of Governmental Industrial Hygienists, Inc., 1986
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
EPASR* United States Environmental Protection Agency, Office of Pesticides and Toxic Substances. (U.S. Environmental Protection Agency, 401 M St., SW, Washington, DC 20460) History unknown.
FAZMAE Fortschritte der Arzneimittelforschung. Progress in Drug Research. (Birkhauser Boston, Inc., c/o Springer-Verlag New York, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1959-
FLCRAP Fluorine Chemistry Reviews. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.1- 1967-
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
VCVGH* "Vrednie chemichescie veshestva, galogenproisvodnie uglevodorodov". (Hazardous substances: Galogenated hydrocarbons) Bandman A.L. et al., Chimia, 1990.
ZAARAM Zentralblatt fuer Arbeitsmedizin und Arbeitsschutz. (Darmstadt, Fed. Rep. Ger.) V.1-25, 1951-75.

RTECS Compound Description:
   Reproductive Effector

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