The Registry of Toxic Effects of Chemical Substances
Methane, dichloro - |
UPDATE: May 2005 | MW: 84.93 | MF: CH2Cl2 |
SYNONYMS:
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SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
|
| EFFECT
REFERENCE
|
eye | rabbit
162 mg
|
moderate
|
EJTXAZ 9,171,1976
|
eye | rabbit
10 mg
|
mild
|
TXCYAC 6,173,1976
|
eye | rabbit
500 mg/24 hour
|
mild
|
85JCAE -,88,1986
|
skin | rabbit
810 mg/24 hour
|
severe
|
EJTXAZ 9,171,1976
|
skin | rabbit
100 mg/24 hour
|
moderate
|
85JCAE -,88,1986
|
|
MUTATION DATA AND REFERENCES:
SYSTEM TEST
|
ROUTE/ | ORGANISM/ TISSUE
DOSE
|
REFERENCE
|
cytogenetic analysis
|
hamster
lung
|
1 µmol/L
|
TECSDY 13,205,1987
|
cytogenetic analysis
|
hamster
ovary
|
6,628 mg/L
|
MUREAV 116,361,1983
|
cytogenetic analysis
|
inhalation | mouse
27,760 mg/m3/6 hour/2 week- intermittent
|
EMMUEG 15,221,1990
|
cytogenetic analysis
|
inhalation | mouse
0.5 ppb
|
EMMUEG 39,69,2002
|
cytogenetic analysis
|
inhalation | rat
0.5 ppb
|
EMMUEG 39,69,2002
|
DNA damage
|
hamster
ovary
|
3,000 ppm
|
MUREAV 367,143,1996
|
DNA damage
|
human
lung
|
1,000 µmol/L/3 hour
|
MUREAV 538,41,2003
|
DNA damage
|
mouse
liver
|
400 µmol/L
|
CRNGDP 15,991,1994
|
DNA damage
|
inhalation | mouse
4,000 ppm/6 hour- continuous
|
CRNGDP 15,991,1994
|
DNA damage
|
oral | mouse
1,720 mg/kg
|
MUREAV 419,13,1998
|
DNA damage
|
oral | rat
1,275 mg/kg
|
TCMUD8 9,61,1989
|
DNA damage
|
rat
liver
|
30 µmol/L
|
CRNGDP 15,991,1994
|
DNA inhibition
|
hamster
lung
|
5,000 ppm/1 hour- continuous
|
MUREAV 81,203,1981
|
DNA inhibition
|
human
fibroblast
|
5,000 ppm/1 hour- continuous
|
MUREAV 81,203,1981
|
mutation in microorganisms
|
Escherichia coli
|
6,300 ppm (+/-enzymatic activation step)
|
EMMUEG 20,211,1992
|
mutation in microorganisms
|
Salmonella typhimurium
|
5,700 ppm (+/-enzymatic activation step)
|
MUREAV 56,245,1978
|
micronucleus test
|
inhalation | mouse
27,760 mg/m3/6 hour/2 week- intermittent
|
EMMUEG 15,221,1990
|
mutation in mammalian somatic cells
|
hamster
ovary
|
3,000 ppm
|
MUREAV 367,143,1996
|
morphological transform
|
hamster
embryo
|
1,300 µL/plate
|
EVSRBT 25,75,1982
|
morphological transform
|
mouse
fibroblast
|
0.1 mg/L/21 day (-enzymatic activation step)
|
EMMUEG 35,300,2000
|
morphological transform
|
rat
embryo
|
160 µmol/L
|
ITCSAF 14,290,1978
|
other mutation test systems
|
hamster
ovary
|
6,628 mg/L
|
MUREAV 116,361,1983
|
phage inhibition capacity
|
Escherichia coli
|
8,250 µg/well
|
MUREAV 260,349,1991
|
sister chromatid exchange
|
hamster
lung
|
5,000 ppm/1 hour- continuous
|
MUREAV 81,203,1981
|
sister chromatid exchange
|
inhalation | mouse
13,880 mg/m3/6 hour/2 week- intermittent
|
EMMUEG 15,221,1990
|
sex chromosome loss and nondisjunction
|
oral | Drosophila melanogaster
125 mmol/L
|
MUREAV 90,91,1981
|
specific locus test
|
inhalation | mouse
0.5 ppb
|
EMMUEG 39,69,2002
|
specific locus test
|
inhalation | rat
0.5 ppb
|
EMMUEG 39,69,2002
|
|
REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
|
| EFFECT
REFERENCE
|
inhalation | mouse
lowest published toxic concentration: 1,250 ppm/7 hour (6-15 day pregnant)
|
Reproductive: Specific developmental abnormalities: Musculoskeletal system
|
TXAPA9 32,84,1975
|
inhalation | rat
lowest published toxic concentration: 4,500 ppm/24 hour (1-17 day pregnant)
|
Reproductive: Effects on newborn: Behavioral
|
TXAPA9 52,29,1980
|
inhalation | rat
lowest published toxic concentration: 1,250 ppm/7 hour (6-15 day pregnant)
|
Reproductive: Specific developmental abnormalities: Musculoskeletal system | Reproductive: Specific developmental abnormalities: Urogenital system
TXAPA9 32,84,1975
|
|
TUMORIGENIC DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
|
| EFFECT
REFERENCE
|
inhalation | mouse
lowest published toxic concentration: 2,000 ppm/5 hour/2 year- continuous
|
Tumorigenic: Carcinogenic by RTECS criteria | Lung, Thorax, or Respiration: Tumors
NTPTR* NTP-TR-306,1986
|
inhalation | mouse
lowest published toxic concentration: 122,400 mg/kg/102 week- intermittent
|
Tumorigenic: Carcinogenic by RTECS criteria | Lung, Thorax, or Respiration: Tumors Liver: Tumors
NTIS** PB86-187903/AS
|
inhalation | rat
lowest published toxic concentration: 3,500 ppm/6 hour/2 year- intermittent
|
Tumorigenic: Carcinogenic by RTECS criteria | Endocrine: Tumors
FAATDF 4,30,1984
|
inhalation | rat
lowest published toxic concentration: 122,400 mg/kg/103 week- intermittent
|
Tumorigenic: Neoplastic by RTECS criteria | Skin and Appendages: Tumors
NTIS** PB86-187903/AS
|
inhalation | rat
lowest published toxic concentration: 102,000 mg/kg/102 week- intermittent
|
Tumorigenic: Neoplastic by RTECS criteria | Skin and Appendages: Tumors Blood: Leukemia
NTIS** PB86-187903/AS
|
|
ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
|
| EFFECT
REFERENCE
|
eye | rabbit
lowest published toxic dose: 0.25 mL/kg
|
Eye: Increased intraocular pressure | Eye: Conjunctiva irritation Eye: Corneal damage
VCVGH* -,323,1990
|
inhalation | cat
lowest published lethal concentration: 43,400 mg/m3/4.5 hour
|
Behavioral: General anesthetic | Behavioral: Ataxia Nutritional and Gross Metabolic: Body temperature decrease
AHBAAM 116,131,1936
|
inhalation | dog
lowest published lethal concentration: 14,108 ppm/7 hour
|
Eye: Miosis (pupilliary constriction) | Vascular: BP lowering not characterized in autonomic section Lung, Thorax, or Respiration: Dyspnea
NIHBAZ 191,1,1949
|
inhalation | guinea pig
lowest published lethal concentration: 5,000 ppm/2 hour
|
N/R
|
FLCRAP 1,197,1967
|
inhalation | guinea pig
lethal concentration (50 percent kill): 40,200 mg/m3/6 hour
|
N/R
|
VCVGH* -,320,1990
|
inhalation | guinea pig
lowest published toxic concentration: 21,000 mg/m3/45 minute
|
Behavioral: General anesthetic
|
VCVGH* -,320,1990
|
inhalation | human
lowest published toxic concentration: 500 ppm/1 year- intermittent
|
Behavioral: Altered sleep time (including change in righting reflex) | Behavioral: Somnolence (general depressed activity) Cardiac: Change in rate
ABHYAE 43,1123,1968
|
inhalation | human
lowest published toxic concentration: 500 ppm/8 hour
|
Behavioral: Euphoria
|
SCIEAS 176,295,1972
|
inhalation | human
lowest published toxic concentration: 69,600 mg/m3/30 minute
|
Behavioral: General anesthetic
|
VCVGH* -,321,1990
|
inhalation | human
lowest published toxic concentration: 25,000 mg/m3/8 minute
|
Peripheral Nerve and Sensation: Paresthesia | Eye: Conjunctiva irritation
VCVGH* -,321,1990
|
inhalation | human
lowest published toxic concentration: 8,000 mg/m3/30 minute
|
Gastrointestinal: Nausea or vomiting
|
VCVGH* -,321,1990
|
inhalation | mouse
lethal concentration (50 percent kill): 14,400 ppm/7 hour
|
N/R
|
NIHBAZ 191,1,1949
|
inhalation | mouse
lowest published toxic concentration: 32,500 mg/m3/2 hour
|
Behavioral: General anesthetic
|
VCVGH* -,307,1990
|
inhalation | mouse
lethal concentration (50 percent kill): 49,100 mg/m3/6 hour
|
N/R
|
VCVGH* -,320,1990
|
inhalation | mouse
lethal concentration (16 percent kill): 53,000 mg/m3/6 hour
|
N/R
|
VCVGH* -,320,1990
|
inhalation | mouse
lethal concentration (50 percent kill): 54,000 mg/m3/2 hour
|
N/R
|
VCVGH* -,320,1990
|
inhalation | mouse
lethal concentration (84 percent kill): 75,000 mg/m3/2 hour
|
N/R
|
VCVGH* -,320,1990
|
inhalation | mouse
lethal concentration (50 percent kill): 56,220 mg/m3/7 hour
|
N/R
|
VCVGH* -,320,1990
|
inhalation | mouse
lowest published toxic concentration: 40,000 mg/m3
|
Behavioral: General anesthetic
|
VCVGH* -,320,1990
|
inhalation | mouse
lowest published toxic concentration: 17,000 mg/m3/2 hour
|
Behavioral: Somnolence (general depressed activity)
|
VCVGH* -,320,1990
|
inhalation | rat
lethal concentration (50 percent kill): 52 gm/m3
|
N/R
|
TPKVAL 15,64,1979
|
inhalation | rat
lethal concentration (50 percent kill): 76,000 mg/m3/4 hour
|
N/R
|
VCVGH* -,320,1990
|
inhalation | rat
lethal concentration (50 percent kill): 52,000 mg/m3/6 hour
|
N/R
|
VCVGH* -,320,1990
|
inhalation | rat
lowest published toxic concentration: 50,000 mg/m3
|
Behavioral: General anesthetic
|
VCVGH* -,320,1990
|
inhalation | rat
lowest published toxic concentration: 1,000 mg/m3/30 minute
|
Endocrine: Adrenal cortex hyperplasia | Behavioral: Alteration of classical conditioning
VCVGH* -,320,1990
|
inhalation | rabbit
lowest published lethal concentration: 10,000 ppm/7 hour
|
N/R
|
JIHTAB 26,8,1944
|
intraperitoneal | dog
lethal dose (50 percent kill): 1,274 mg/kg
|
N/R
|
TXAPA9 10,119,1967
|
intraperitoneal | mouse
lethal dose (50 percent kill): 437 mg/kg
|
N/R
|
AGGHAR 18,109,1960
|
intraperitoneal | rat
lethal dose (50 percent kill): 916 mg/kg
|
N/R
|
ENVRAL 40,411,1986
|
intraperitoneal | rat
lowest published toxic dose: 510 mg/kg
|
Blood: Methemoglobinemia- Carboxhemoglobinemia
|
VCVGH* -,320,1990
|
intratracheal | rat
lowest published lethal dose: 350 mg/kg
|
Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi | Lung, Thorax, or Respiration: Acute pulmonary edema
NTIS** OTS0520615
|
intravenous | dog
lowest published lethal dose: 200 mg/kg
|
N/R
|
QJPPAL 7,205,1934
|
intravenous | mouse
lowest published toxic dose: 133 mg/kg
|
Kidney, Ureter, and Bladder: Other changes
|
VCVGH* -,320,1990
|
intravenous | rat
lowest published toxic dose: 1,000 mg/kg
|
Liver: Other changes | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Cytochrome oxidases (indlucing oxidative phosphrylation)
VCVGH* -,320,1990
|
oral | dog
lowest published lethal dose: 3 gm/kg
|
N/R
|
QJPPAL 7,205,1934
|
oral | dog
lethal dose (50 percent kill): 3,000 mg/kg
|
N/R
|
VCVGH* -,320,1990
|
oral | human
lowest published lethal dose: 357 mg/kg
|
Peripheral Nerve and Sensation: Paresthesia | Behavioral: Somnolence (general depressed activity) Behavioral: Convulsions or effect on seizure threshold
34ZIAG -,390,1969
|
oral | man
lowest published toxic dose: 1,429 µL/kg
|
Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) | Blood: Normocytic anemia Nutritional and Gross Metabolic: Changes in: Fe
YAKUD5 36,575,1994
|
oral | mouse
lethal dose (50 percent kill): 873 mg/kg
|
N/R
|
EVHPAZ 106(Suppl 2),497,1998
|
oral | mouse
lethal dose (16 percent kill): 620 mg/kg
|
N/R
|
VCVGH* -,320,1990
|
oral | mouse
lethal dose (84 percent kill): 1,650 mg/kg
|
N/R
|
VCVGH* -,320,1990
|
oral | rat
lethal dose (50 percent kill): 1,600 mg/kg
|
Behavioral: Ataxia
|
FAONAU 48A,94,1970
|
oral | rat
lethal dose (50 percent kill): 985 mg/kg
|
N/R
|
VCVGH* -,320,1990
|
oral | rat
lethal dose (16 percent kill): 800 mg/kg
|
N/R
|
VCVGH* -,320,1990
|
oral | rat
lethal dose (84 percent kill): 2,200 mg/kg
|
N/R
|
VCVGH* -,320,1990
|
oral | rat
lowest published toxic dose: 237.8 mg/kg
|
Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)
|
VCVGH* -,321,1990
|
oral | rabbit
lowest published lethal dose: 1,900 mg/kg
|
N/R
|
HBTXAC 1,94,1955
|
oral | rabbit
lethal dose (50 percent kill): 2,000 mg/kg
|
N/R
|
VCVGH* -,320,1990
|
subcutaneous | mouse
lethal dose (50 percent kill): 6,460 mg/kg
|
N/R
|
TXAPA9 4,354,1962
|
subcutaneous | rabbit
lowest published lethal dose: 2,700 mg/kg
|
N/R
|
QJPPAL 7,205,1934
|
unreported route | mouse
lethal dose (50 percent kill): 4,770 mg/kg
|
Gastrointestinal: Ulceration or bleeding from stomach | Gastrointestinal: Ulceration or bleeding from small intestine
ESKGA2 28,P31,1982
|
unreported route | rat
lethal dose (50 percent kill): 5,350 mg/kg
|
N/R
|
GISAAA 53(6),78,1988
|
unreported route | rabbit
lethal dose (50 percent kill): 1,225 mg/kg
|
N/R
|
GISAAA 53(6),78,1988
|
|
OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
|
| EFFECT
REFERENCE
|
inhalation | dog
lowest published toxic concentration: 1,000 ppm/24 hour/7 week- continuous
|
Behavioral: Food intake (animal) | Musculoskeletal: Other changes Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
NTIS** AD746-295
|
inhalation | dog
lowest published toxic concentration: 5,000 ppm/6 hour/12 week- intermittent
|
Behavioral: Hallucinations, distorted perceptions | Behavioral: Ataxia Behavioral: Antipsychotic
NTIS** OTS0555748
|
inhalation | guinea pig
lowest published toxic concentration: 552 ppm/6 hour/5 day- intermittent
|
Liver: Other changes | Biochemical: Metabolism (intermediary): Lipids including transport
AIHAAP 37,345,1976
|
inhalation | monkey
lowest published toxic concentration: 5,000 ppm/24 hour/32 day- continuous
|
Behavioral: Food intake (animal) | Nutritional and Gross Metabolic: Weight loss or decreased weight gain Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
NTIS** AD746-295
|
inhalation | mouse
lowest published toxic concentration: 13,000 ppm/6 hour/19 day- intermittent
|
Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
|
NTPTR* NTP-TR-306,1986
|
inhalation | mouse
lowest published toxic concentration: 150 ppm/24 hour/30 day- continuous
|
Liver: Changes in liver weight | Endocrine: Changes in spleen weight Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other esterases
APTOA6 59,73,1986
|
inhalation | mouse
lowest published toxic concentration: 5,000 ppm/24 hour/7 day- continuous
|
Liver: Changes in liver weight | Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TXAPA9 23,660,1972
|
inhalation | mouse
lowest published toxic concentration: 300 ppm/24 hour/90 day- continuous
|
Liver: Changes in liver weight | Endocrine: Changes in spleen weight Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other esterases
APTOA6 59,73,1986
|
inhalation | rat
lowest published toxic concentration: 3,700 ppm/5 hour/4 week- intermittent
|
Lung, Thorax, or Respiration: Other changes | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases
TOLED5 7,41,1980
|
inhalation | rat
lowest published toxic concentration: 5,000 ppm/24 hour/14 week- continuous
|
Liver: Other changes | Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) Kidney, Ureter, and Bladder: Changes in bladder weight
NTIS** AD746-295
|
inhalation | rat
lowest published toxic concentration: 8,400 ppm/6 hour/13 week- intermittent
|
Liver: Changes in liver weight | Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
NTPTR* NTP-TR-306,1986
|
inhalation | rat
lowest published toxic concentration: 500 ppm/6 hour/2 week- intermittent
|
Kidney, Ureter, and Bladder: Other changes | Blood: Methemoglobinemia- Carboxhemoglobinemia Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes
RCOCB8 32,535,1981
|
inhalation | rat
lowest published toxic concentration: 1,000 ppm/2 hour/3 week- intermittent
|
Behavioral: Food intake (animal) | Liver: Other changes Blood: Other changes
HOCHE8 8,64,1990
|
inhalation | rat
lowest published toxic concentration: 1,000 ppm/6 hour/3 day- intermittent
|
Brain and Coverings: Other degenerative changes | Biochemical: Neurotransmitters or modulators (putative): Dopamine at other sites
TXCYAC 29,293,1984
|
oral | mouse
lowest published toxic dose: 1,862 mg/kg/2 week- intermittent
|
Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)
|
DCTODJ 6,563,1983
|
oral | mouse
lowest published toxic dose: 52,740 mg/kg/90 day- continuous
|
Liver: Hepatitis (hepatocellular necrosis), zonal | Liver: Fatty liver degeneration
FCTOD7 24,943,1986
|
oral | rat
lowest published toxic dose: 14,940 mg/kg/90 day- continuous
|
Liver: Hepatitis (hepatocellular necrosis), zonal | Liver: Fatty liver degeneration
FCTOD7 24,943,1986
|
oral | rat
lowest published toxic dose: 91 gm/kg/2 year- continuous
|
Behavioral: Fluid intake | Liver: Fatty liver degeneration Nutritional and Gross Metabolic: Weight loss or decreased weight gain
FCTOD7 24,951,1986
|
skin | rat
lowest published toxic dose: 39,270 mg/kg/17 week- intermittent
|
Liver: Other changes | Liver: Changes in liver weight
GTPZAB 26(5),41,1982
|
|
REVIEWS:
ORGANIZATION
|
STANDARD
|
|
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
|
time-weighted average 50 ppm
|
DTLVS* TLV/BEI,2003
|
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
|
Confirmed Animal Carcinogen with Unknown
|
DTLVS* TLV/BEI,2003
|
International Agency for Research on Cancer (IARC) Cancer Review
|
Animal Sufficient Evidence
|
IMEMDT 41,43,1986
|
International Agency for Research on Cancer (IARC) Cancer Review
|
Animal Sufficient Evidence
|
IMEMDT 71,251,1999
|
International Agency for Research on Cancer (IARC) Cancer Review
|
Human Inadequate Evidence
|
IMEMDT 41,43,1986
|
International Agency for Research on Cancer (IARC) Cancer Review
|
Human Inadequate Evidence
|
IMEMDT 71,251,1999
|
International Agency for Research on Cancer (IARC) Cancer Review
|
Group 2B
|
IMEMDT 71,251,1999
|
TOXICOLOGY REVIEW
|
|
TOLED5 127,135,2002
|
TOXICOLOGY REVIEW
|
|
TOLED5 138,9,2003
|
TOXICOLOGY REVIEW
|
|
MUREAV 543,201,2003
|
TOXICOLOGY REVIEW
|
|
MUREAV 5432012003
|
TOXICOLOGY REVIEW
|
|
MUREAV 567,227,2004
|
TOXICOLOGY REVIEW
|
|
MUREAV 567,109,2004
|
TOXICOLOGY REVIEW
|
|
MUREAV 567,151,2004
|
|
STANDARDS AND REGULATIONS:
ORGANIZATION
|
STANDARD
|
|
REFERENCE
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988
|
PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION
|
FEREAC 54,7740,1989
|
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF
|
PESTICIDES: Cancelled
|
RBREV* -,263,1998
|
Mine Safety and Health Administration (MSHA) STANDARD - air
|
time-weighted average 500 ppm (1750 mg/m3)
|
DTLVS* 3,171,1971
|
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)
|
8 hour time-weighted average 500 ppm; | ceiling concentration 1000 ppm; peak concentration 2000 ppm/5 minute/2 hour
CFRGBR 29,1910.1000,1994
|
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)
|
see 56 FR 57036
|
CFRGBR 29,1926.55,1994
|
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)
|
8 hour time-weighted average 500 ppm (1740 mg/m3
|
CFRGBR 29,1915.1000,1993
|
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)
|
8 hour time-weighted average 500 ppm (1740 mg/m3)
|
CFRGBR 41,50-204.50,1994
|
Occupational Exposure Limit - AUSTRALIA
|
time-weighted average 100 ppm (350 mg/m3), Carcinogen, JAN1993
|
Occupational Exposure Limit - AUSTRIA
|
MAK 100 ppm (360 mg/m3), Suspected Carcinogen, JAN1999
|
Occupational Exposure Limit - BELGIUM
|
time-weighted average 50 ppm (174 mg/m3), Carcinogen, JAN1993
|
Occupational Exposure Limit - DENMARK
|
time-weighted average 35 ppm (122 mg/m3), Skin, JAN1999
|
Occupational Exposure Limit - FINLAND
|
time-weighted average 100 ppm (350 mg/m3), short term exposure limit 250 ppm (870 mg/m3), JAN1999
|
Occupational Exposure Limit - FRANCE
|
VME 50 ppm (180 mg/m3), VLE 100 ppm, continuous3 Carcinogen, JAN1999
|
Occupational Exposure Limit - GERMANY
|
MAK 100 ppm (360 mg/m3), Carcinogen, JAN1999
|
Occupational Exposure Limit - HUNGARY
|
short term exposure limit 10 mg/m3, Carcinogen, JAN1993
|
Occupational Exposure Limit - THE NETHERLANDS
|
MAC-TGG 350 mg/m3, 2003
|
Occupational Exposure Limit - NORWAY
|
time-weighted average 35 ppm (125 mg/m3), JAN1999
|
Occupational Exposure Limit - THE PHILIPPINES
|
time-weighted average 500 ppm (1740 mg/m3), JAN1993
|
Occupational Exposure Limit - POLAND
|
MAC(time-weighted average) 20 mg/m3, short term exposure limit 50 mg/m3, JAN1999
|
Occupational Exposure Limit - RUSSIA
|
time-weighted average 100 ppm, short term exposure limit 50 mg/m3, JAN1993
|
Occupational Exposure Limit - SWEDEN
|
NGV 35 ppm (120 mg/m3), KTV 70 ppm (250 mg/m3), Skin JAN1999
|
Occupational Exposure Limit - SWITZERLAND
|
MAK- week 100 ppm (360 mg/m3), KZG- week 500 ppm (1800 mg/m3), JAN1999
|
Occupational Exposure Limit - THAILAND
|
time-weighted average 500 mg/m3, short term exposure limit 1000 mg/m3, JAN1993
|
Occupational Exposure Limit - TURKEY
|
time-weighted average 500 ppm (1740 mg/m3), JAN1993
|
Occupational Exposure Limit - UNITED KINgDOM
|
time-weighted average 100 ppm (350 mg/m3), short term exposure limit 300 ppm, SEP2000
|
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA
|
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value; | Confirmed Animal Carcinogen with Unknown
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM
|
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value |
Confirmed Animal Carcinogen with Unknown |
NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION
|
STANDARD or SURVEY
|
|
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO METHYLENE CHLORIDE-air
|
Carcinogen lowest feasible concentration
|
NIOSH* DHHS #92-100,1992
|
National Occupational Hazard Survey 1974
|
National Occupational Hazard Survey 1974: Hazard Code: 47270; | Number of Industries 374; Total Number of Facilities 89,025; Number of Occupations 192; Total Number of Employees Exposed 975,696
National Occupational Exposure Survey 1983
|
National Occupational Exposure Survey 1983: Hazard Code: 47270; |
Number of Industries 363; Total Number of Facilities 87,086; Number of Occupations 212; Total Number of Employees Exposed 1,438,196; Total Number of Female Employees Exposed 352,536 |
STATUS IN FEDERAL AGENCIES:
ORGANIZATION
|
|
REFERENCE
ATSDR TOXICOLOGY PROFILE (NTIS** PB/2000/108026)
|
EPA GENETOX PROGRAM 1988, Positive: Cell transform.-RLV F344 rat embryo
|
EPA GENETOX PROGRAM 1988, Positive: Histidine reversion-Ames test
|
EPA GENETOX PROGRAM 1988, Positive: S cerevisiae gene conversion; S cerevisiae-homozygosis
|
EPA GENETOX PROGRAM 1988, Positive: S cerevisiae-reversion
|
EPA GENETOX PROGRAM 1988, Negative: D melanogaster Sex-linked lethal
|
EPA TSCA Section 8(b) CHEMICAL INVENTORY
|
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULE
|
FEREAC 47,26992,82
|
Used as a paint remover, degreaser, solvent and in aerosol propellants
|
EPA TSCA Section 8(d) unpublished health/safety studies
|
On EPA IRIS database
|
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
|
NIOSH CURRENT INTELLIGENCE BULLETIN 46, 1986
|
NIOSH Analytical Method, 1994: Methylene chloride, 1005
|
NIOSH Analytical Method, 1996: Volatile organic compound, 2549
|
NCI Carcinogenesis Studies (inhal);clear evidence:mouse,rat
|
NTP 11th Report on Carcinogens,2004:Reasonably anticipated to be a human carcinogen
|
OSHA ANALYTICAL METHOD #80
|
|
REFERENCES:
CODEN
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REFERENCE
34ZIAG
|
"Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969
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85JCAE
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AGGHAR
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AHBAAM
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AIHAAP
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APTOA6
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DTLVS*
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The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by
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EJTXAZ
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EMMUEG
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|
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|