The Registry of Toxic Effects of Chemical Substances

Methanamine, N,N - dimethyl -

RTECS #: PA0350000

CAS #: 75-50-3

UPDATE: November 2004 MW: 59.13 MF: C3H9N


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. REPRODUCTIVE EFFECTS DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. Dimethylmethaneamine
  2. N,N - Dimethylmethanamine
  1. Trimethylamine
  2. Trimethylamine (ACGIH)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lowest published toxic dose: 4,430 mg/kg (6-15 day pregnant) Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Effects on newborn: Physical 		CJPPA3 71,185,1993
intraperitoneal
mouse 		lowest published toxic dose: 2,960 mg/kg (6-15 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) CJPPA3 71,185,1993


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mammal (species unspecified) 		lethal concentration (50 percent kill): 19 gm/m3 N/R TPKVAL 14,80,1975
inhalation
mouse 		lethal concentration (50 percent kill): 19 gm/m3 Behavioral: Somnolence (general depressed activity)

Behavioral: Excitement

Behavioral: Muscle contraction or spasticity 		GTPZAB 11(4),26,1967
inhalation
rat 		lowest published lethal concentration: 3,500 ppm/4 hour N/R TOXID9 4,68,1984
intraperitoneal
mouse 		lethal dose (50 percent kill): 946 mg/kg N/R YKKZAJ 97,1117,1977
intravenous
mouse 		lethal dose (50 percent kill): 90 mg/kg N/R MPHEAE 16,529,1967
intravenous
rabbit 		lowest published lethal dose: 160 mg/kg N/R CRSBAW 83,481,1920
oral
pig 		lowest published lethal dose: 1 gm/kg Peripheral Nerve and Sensation: Spastic paralysis with/without sensory change

Behavioral: Food intake (animal) 		INHTE5 2,41,1990
oral
rat 		lethal dose (50 percent kill): 500 mg/kg N/R INHTE5 2,41,1990
rectal
rabbit 		lowest published lethal dose: 800 mg/kg N/R CRSBAW 83,481,1920
subcutaneous
frog 		lowest published lethal dose: 2 gm/kg Cardiac: Pulse rate decreased with fall in BP

Cardiac: Other changes

Blood: Other changes 		SAPHAO 10,201,1900
subcutaneous
rabbit 		lowest published lethal dose: 800 mg/kg N/R CRSBAW 83,481,1920
unreported route
guinea pig 		lethal dose (50 percent kill): 315 mg/kg N/R GISAAA 46(8),79,1981
unreported route
mouse 		lethal dose (50 percent kill): 460 mg/kg N/R GISAAA 46(8),79,1981
unreported route
rat 		lethal dose (50 percent kill): 535 mg/kg N/R GISAAA 46(8),79,1981
unreported route
rabbit 		lethal dose (50 percent kill): 240 mg/kg N/R GISAAA 46(8),79,1981


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published toxic concentration: 75 mg/m3/5 hour/30 week- intermittent Lung, Thorax, or Respiration: Fibrosis, focal (pneumoconiosis)

Endocrine: Changes in adrenal weight

Blood: Changes in other cell count (unspecified) 		GTPZAB 11(4),26,1967
inhalation
rat 		lowest published toxic concentration: 750 ppm/6 hour/2 week- intermittent Olfaction: Other olfaction effects

Blood: Changes in erythrocyte (RBC) count

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		INHTE5 2,41,1990
unreported route
rabbit 		lowest published toxic dose: 437 mg/kg/26 week- intermittent Blood: Changes in erythrocyte (RBC) count

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Monoamine oxidase

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases 		GISAAA 46(8),79,1981


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 5 ppm DTLVS* TLV/BEI,2003
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value short term exposure limit 15 ppm DTLVS* TLV/BEI,2003
TOXICOLOGY REVIEW
CHREAY 9,389,1931


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Exposure Limit - AUSTRALIA time-weighted average 10 ppm (24 mg/m3), short term exposure limit 15 ppm, JAN1993
Occupational Exposure Limit - BELGIUM time-weighted average 10 ppm (24 mg/m3), short term exposure limit 15 ppm, JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 10 ppm (24 mg/m3), JAN1999
Occupational Exposure Limit - FRANCE VLE 10 ppm (25 mg/m3), JAN1999
Occupational Exposure Limit - GERMANY No MAK Established, JAN1999
Occupational Exposure Limit - HUNGARY time-weighted average 5 mg/m3, short term exposure limit 10 mg/m3, JAN1993
Occupational Exposure Limit - NORWAY time-weighted average 10 ppm (24 mg/m3), JAN1999
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 1 mg/m3, 2003
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

short term exposure limit 15 ppm
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
short term exposure limit 15 ppm


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO TRIMETHYLAMINE-air 10 hour time-weighted average 10 ppm;
short term exposure limit 15 ppm 		NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 82039;
Number of Industries 6;
Total Number of Facilities 387;
Number of Occupations 11;
Total Number of Employees Exposed 3,900
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 82039;
Number of Industries 7;
Total Number of Facilities 142;
Number of Occupations 13;
Total Number of Employees Exposed 5,261;
Total Number of Female Employees Exposed 2,870


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as an insect attractant, warning agent in natural gas, flotation agent, and intermediate
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
CHREAY Chemical Reviews. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) V.1- 1924-
CJPPA3 Canadian Journal of Physiology and Pharmacology. (National Research Council of Canada, Publication Sales and Distribution, Ottawa ON K1A OR6, Canada) V.42- 1964-
CRSBAW Comptes Rendus des Seances de la Societe de Biologie et de Ses Filiales. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1849-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
INHTE5 Inhalation Toxicology. (Published by Taylor & Francis Health, 11 New Fetter Lane, London EC4P 4EE) V.1- 1989-
MPHEAE Medicina et Pharmacologia Experimentalis. (Basel, Switzerland) V.12-17, 1965-67. For publisher information, see PHMGBN.
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
SAPHAO Skandinavisches Archiv fuer Physiologie. (Stockholm, Sweden) V.1-83, 1899-1940. For publisher information, see APSCAX.
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. (Izdatel'stvo Meditsina, Moscow, USSR) No.1- 1961-
YKKZAJ Yakugaku Zasshi. Journal of Pharmacy. (Nippon Yakugakkai, 2-12-15 Shibuya, Shibuya-ku, Tokyo 150, Japan) No.1- 1881-

Used as an insect attractant, warning agent in natural gas, flotation agent, and intermediate

NIOSH PROFILE (AMINES, TERTIARY ALIPHATIC), SRI, 2/77

RTECS Compound Description:
   Reproductive Effector

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