The Registry of Toxic Effects of Chemical Substances

Methane, bromotrifluoro -

RTECS #: PA5425000

CAS #: 75-63-8

UPDATE: November 2004 MW: 148.92 MF: CBrF3


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. ACUTE TOXICITY DATA:
  3. REVIEWS:
  4. STANDARDS AND REGULATIONS:
  5. NIOSH DOCUMENTATION AND SURVEILLANCE:
  6. STATUS IN FEDERAL AGENCIES:
  7. REFERENCES:

SYNONYMS:

  1. Bromofluoroform
  2. Bromotrifluoromethane
  3. Daiflon 13B1
  4. F - 13B1
  5. FE 1301
  6. Flugex 13B1
  7. Freon 13B1
  1. Halon 1301
  2. R 13B1
  3. Refrigerant 13B1
  4. Trifluorobromomethane
  5. Trifluorobromomethane (ACGIH:OSHA)
  6. Trifluoromonobromomethane


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
dog 		lethal concentration : >30 pph/15 minute Behavioral: Tremor

Gastrointestinal: Changes in structure or function of salivary glands 		NTIS** OTS0571524
inhalation
dog 		lowest published toxic concentration: 1,662 mg/m3/45 minute Blood: Other changes VCVGH* -,625,1990
inhalation
dog 		lowest published toxic concentration: 1,330 mg/m3/20S Behavioral: Convulsions or effect on seizure threshold

Cardiac: Arrythmias (indlucing changes in conduction)

Vascular: BP lowering not characterized in autonomic section 		VCVGH* -,625,1990
inhalation
guinea pig 		lethal concentration (50 percent kill): 88,000 ppm/15 minute N/R 85INA8 6,1640,1991
inhalation
human 		lowest published toxic concentration: 997.5 mg/m3/1 minute Behavioral: Ataxia VCVGH* -,626,1990
inhalation
human 		lowest published toxic concentration: 399 mg/m3/3 minute Peripheral Nerve and Sensation: Paresthesia

Behavioral: Ataxia

Behavioral: Headache 		VCVGH* -,626,1990
inhalation
man 		lethal concentration : >15 pph/1 minute Behavioral: Hallucinations, distorted perceptions

Cardiac: Pulse rate increased without fall in BP 		NTIS** OTS0571524
inhalation
monkey 		lowest published toxic concentration: 2,660 mg/m3/2 minute Behavioral: Convulsions or effect on seizure threshold

Behavioral: General anesthetic 		VCVGH* -,625,1990
inhalation
monkey 		lowest published toxic concentration: 1,330 mg/m3/15 minute Behavioral: Convulsions or effect on seizure threshold

Behavioral: General anesthetic 		VCVGH* -,625,1990
inhalation
mouse 		lethal concentration (50 percent kill): 381 gm/m3 N/R GTPZAB 26(8),53,1982
inhalation
mouse 		lethal concentration (50 percent kill): 350 mg/m3/2 hour N/R VCVGH* -,625,1990
inhalation
rat 		lethal concentration (50 percent kill): 84,000 ppm/15 minute N/R 85INA8 6,1640,1991
inhalation
rat 		lowest published lethal concentration: 5,054 mg/m3/15 minute N/R VCVGH* -,625,1990
inhalation
rat 		lowest published toxic concentration: 4,056 mg/m3/2 minute Behavioral: General anesthetic VCVGH* -,625,1990
inhalation
rat 		lowest published toxic concentration: 2,128 mg/m3/12 minute Behavioral: General anesthetic VCVGH* -,625,1990
inhalation
rat 		lethal concentration (50 percent kill): 430 mg/m3/4 hour N/R VCVGH* -,625,1990


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 1000 ppm DTLVS* TLV/BEI,2003


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 1000 ppm (6100 mg/m3) DTLVS* 3,268,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 1000 ppm (6100 mg/m3) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 1000 ppm (6100 mg/m3) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 1000 ppm (6100 mg/m3) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 1000 ppm (6100 mg/m3) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 1000 ppm (6100 mg/m3), JAN1993
Occupational Exposure Limit - AUSTRIA MAK 1000 ppm (6100 mg/m3), JAN1999
Occupational Exposure Limit - BELGIUM time-weighted average 1000 ppm (6090 mg/m3), JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 1000 ppm (6100 mg/m3), JAN1999
Occupational Exposure Limit - FINLAND time-weighted average 1000 ppm (6100 mg/m3), short term exposure limit 1250 ppm (7625 mg/m3), JAN1999
Occupational Exposure Limit - FRANCE VME 1000 ppm (6100 mg/m3), JAN1999
Occupational Exposure Limit - GERMANY MAK 1000 ppm (6100 mg/m3), JAN1999
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 6100 mg/m3, 2003
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 1000 ppm (6100 mg/m3), JAN1993
Occupational Exposure Limit - RUSSIA short term exposure limit 3000 mg/m3, JAN1993
Occupational Exposure Limit - SWITZERLAND MAK- week 1000 ppm (6100 mg/m3), JAN1999
Occupational Exposure Limit - TURKEY time-weighted average 1000 ppm (6100 mg/m3), JAN1993
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 1000 ppm (6190 mg/m3), short term exposure limit 1200 ppm, SEP2000
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 1000 ppm
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 1000 ppm


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO TRIFLUOROBROMOMETHANE-air 10 hour time-weighted average 1000 ppm NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: M0424;
Number of Industries 1;
Total Number of Facilities 32;
Number of Occupations 1;
Total Number of Employees Exposed 32


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as a fire extinquishant and as a chemical intermediate
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Bromotrifluoromethane, 1017
NIOSH Analytical Method, 1994: Trifluorobromomethane, 1017


REFERENCES:

CODEN
REFERENCE
85INA8 "Documentation of the Threshold Limit Values and Biological Exposure Indices," 5th ed., Cincinnati, OH, American Conference of Governmental Industrial Hygienists, Inc., 1986
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
VCVGH* "Vrednie chemichescie veshestva, galogenproisvodnie uglevodorodov". (Hazardous substances: Galogenated hydrocarbons) Bandman A.L. et al., Chimia, 1990.

Used as a fire extinquishant and as a chemical intermediate

NIOSH PROFILE (FIREFIGHTING), FIRL, 4/78

RTECS Compound Description:
   Human Data

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