The Registry of Toxic Effects of Chemical Substances

Methane, bromochlorodifluoro -

RTECS #: PA5270000

CAS #: 353-59-3

UPDATE: February 2004 MW: 165.37 MF: CBrClF2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. STANDARDS AND REGULATIONS:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. BCF
  2. Chlorodifluoromonobromomethane
  3. Daiflon 12B1
  4. Dwufluorochlorobromometan (Polish)
  5. Flugex 12B1
  1. Fluorocarbon 1211
  2. Freon 12B1
  3. Bromochlorodifluoromethane
  4. Halon 1211


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
mutation in microorganisms Salmonella typhimurium 10 pph (+enzymatic activation step) MUREAV 142,187,1985


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published toxic concentration: 50,000 ppm (6-15 day pregnant) Reproductive: Other effects on female BJIMAG 45,755,1988


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
dog 		lowest published lethal concentration: 5 pph/30 minute Behavioral: Tremor

Behavioral: Convulsions or effect on seizure threshold

Cardiac: Other changes 		NTIS** OTS0571363
inhalation
guinea pig 		lowest published lethal concentration: 30 pph/2 hour Behavioral: Convulsions or effect on seizure threshold ZAARAM 21,149,1971
inhalation
human 		lowest published toxic concentration: 295,200 mg/m3/1 minute Peripheral Nerve and Sensation: Paresthesia VCVGH* -,631,1990
inhalation
man 		lowest published toxic concentration: 4 pph/1 minute Peripheral Nerve and Sensation: Paresthesia

Behavioral: Hallucinations, distorted perceptions

Cardiac: EKG changes not diagnostic of above 		NTIS** OTS0571363
inhalation
rat 		lethal concentration (50 percent kill): 20 pph/15 minute Behavioral: Tremor

Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Respiratory depression 		HUTODJ 1,239,1982
inhalation
rat 		lethal concentration (50 percent kill): 2,140,000 mg/m3/5 minute N/R VCVGH* -,631,1990
inhalation
rat 		lowest published toxic concentration: 396,000 mg/m3/10 minute Behavioral: General anesthetic VCVGH* -,631,1990


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published toxic concentration: 210 µg/m3/4 hour/12 week- intermittent Blood: Pigmented or nucleated red blood cells

Blood: Changes in erythrocyte (RBC) count

Blood: Changes in platelet count 		BCTKAG 17,41,1984
inhalation
rat 		lowest published toxic concentration: 1 pph/6 hour/3 week- intermittent Behavioral: Somnolence (general depressed activity) NTIS** OTS0571363


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Exposure Limit - RUSSIA short term exposure limit 1000 mg/m3, JAN1993


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
N/R N/R N/R


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used in fire extinguishers
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-9154
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
BCTKAG Bromatologia i Chemia Toksykologiczna. (Ars Polona, POB 1001, 00-068 Warsaw 1, Poland) V.4- 1971-
BJIMAG British Journal of Industrial Medicine. (British Medical Journal, Box 560B, Kennebunkport, ME 04046) V.1- 1944-
HUTODJ Human Toxicology. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants., RG 21 2XS, UK) V.1- 1981-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
VCVGH* "Vrednie chemichescie veshestva, galogenproisvodnie uglevodorodov". (Hazardous substances: Galogenated hydrocarbons) Bandman A.L. et al., Chimia, 1990.
ZAARAM Zentralblatt fuer Arbeitsmedizin und Arbeitsschutz. (Darmstadt, Fed. Rep. Ger.) V.1-25, 1951-75.

Used in fire extinguishers

NIOSH PROFILE (FIREFIGHTING), FIRL, 4/78

RTECS Compound Description:
   Mutagen
   Reproductive Effector
   Human Data

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