The Registry of Toxic Effects of Chemical Substances

Methane, bromochloro -

RTECS #: PA5250000

CAS #: 74-97-5

UPDATE: November 2004 MW: 129.39 MF: CH2BrCl


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. Bromochloromethane
  2. Chlorobromomethane
  3. Chlorobromomethane (ACGIH:OSHA)
  4. Fluorocarbon 1011
  5. Halon 1011
  1. Methylene chlorobromide
  2. Mil - B - 4394 - B
  3. Mono - chloro - mono - bromo - methane
  4. Monochloromonobromomethane


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis hamster lung 1 µmol/L TECSDY 13,205,1987
mutation in microorganisms Salmonella typhimurium 10 mg/plate (+enzymatic activation step) DHEFDK FDA-78-1046,1978
mutation in microorganisms Salmonella typhimurium 10 µg/plate (-enzymatic activation step) TECSDY 13,205,1987
sister chromatid exchange hamster lung 5 µmol/L TECSDY 13,205,1987


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mouse 		lethal concentration (50 percent kill): 12,030 mg/m3/7 hour Behavioral: General anesthetic

Behavioral: Muscle weakness

Lung, Thorax, or Respiration: Dyspnea 		JIHTAB 29,382,1947
inhalation
rat 		lowest published lethal concentration: 28,800 ppm/15 minute Behavioral: General anesthetic

Behavioral: Altered sleep time (including change in righting reflex)

Behavioral: Tremor 		MRLR** #113,1952
inhalation
rat 		lowest published toxic concentration: 7,800 mg/m3/3 hour Behavioral: General anesthetic VCVGH* -,627,1990
inhalation
rat 		lowest published lethal concentration: 53,000 mg/m3/15 minute N/R VCVGH* -,627,1990
oral
mouse 		lethal dose (50 percent kill): 4,300 mg/kg Behavioral: General anesthetic JIHTAB 29,382,1947
oral
rat 		lethal dose (50 percent kill): 5 gm/kg N/R 34ZIAG -,390,1969
skin
rabbit 		lethal dose (50 percent kill): >20 gm/kg N/R NTIS** AD-A062-138


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
dog 		lowest published toxic concentration: 500 ppm/6 hour/26 week- intermittent Nutritional and Gross Metabolic: Changes in: Other metals JOCMA7 8,251,1966
inhalation
rat 		lowest published toxic concentration: 1,000 ppm/7 hour/16 week- intermittent Liver: Fatty liver degeneration

Kidney, Ureter, and Bladder: Changes in bladder weight

Nutritional and Gross Metabolic: Changes in: Other metals 		AIHAAP 21,275,1960
inhalation
rat 		lowest published toxic concentration: 500 ppm/6 hour/26 week- intermittent Lung, Thorax, or Respiration: Fibrosis, focal (pneumoconiosis)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Nutritional and Gross Metabolic: Changes in: Other metals 		JOCMA7 8,251,1966
inhalation
rabbit 		lowest published toxic concentration: 1,000 ppm/7 hour/16 week- intermittent Nutritional and Gross Metabolic: Changes in: Other metals AIHAAP 21,275,1960


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 200 ppm DTLVS* TLV/BEI,2003


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 200 ppm (1050 mg/m3) DTLVS* 3,50,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 200 ppm (1050 mg/m3) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 200 ppm (1050 mg/m3) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 200 ppm (1050 mg/m3) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 200 ppm (1050 mg/m3) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 200 ppm (1050 mg/m3), short term exposure limit 250 ppm, JAN1993
Occupational Exposure Limit - AUSTRIA MAK 200 ppm (1050 mg/m3), JAN1999
Occupational Exposure Limit - DENMARK time-weighted average 200 ppm (1050 mg/m3), JAN1999
Occupational Exposure Limit - FINLAND time-weighted average 200 ppm (1050 mg/m3), short term exposure limit 250 ppm (1315 mg/m3), JAN1999
Occupational Exposure Limit - FRANCE VME 200 ppm (1050 mg/m3), JAN1993
Occupational Exposure Limit - GERMANY MAK 200 ppm (1050 mg/m3), JAN1999
Occupational Exposure Limit - NORWAY time-weighted average 100 ppm (525 mg/m3), JAN1999
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 1050 mg/m3, 2003
Occupational Exposure Limit - POLAND time-weighted average 1000 mg/m3, short term exposure limit 1300 mg/m3, JAN1999
Occupational Exposure Limit - SWITZERLAND MAK- week 200 ppm (1050 mg/m3), KZG- week 400 ppm (2100 mg/m3), JAN1999
Occupational Exposure Limit - TURKEY time-weighted average 200 ppm (1050 mg/m3), JAN1993
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 200 ppm (1080 mg/m3), short term exposure limit 250 ppm, SEP2000
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 200 ppm
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 200 ppm


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO CHLOROBROMOMETHANE-air 10 hour time-weighted average 200 ppm NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 18250;
Number of Industries 1;
Total Number of Facilities 7;
Number of Occupations 2;
Total Number of Employees Exposed 56
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 18250;
Number of Industries 1;
Total Number of Facilities 35;
Number of Occupations 1;
Total Number of Employees Exposed 71


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as brominated lame retardants and a fire-extinguishing agent
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Hydrocarbons, halogenated, 1003


REFERENCES:

CODEN
REFERENCE
34ZIAG "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DHEFDK HEW Publication (FDA. United States). (Washington, DC) ?-1979(?). For publisher information, see HPFSDS.
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU.
JOCMA7 Journal of Occupational Medicine. (Chicago, IL) V.1-9, 1957-67. For publisher information, see:JJOMDZ
MRLR** U.S. Army, Chemical Corps Medical Laboratories Research Reports. (Army Chemical Center, Edgewood Arsenal, MD)
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
TECSDY Toxicological and Environmental Chemistry. (Gordon & Breach Science Pub. Inc., 1 Park Ave., New York, NY 10016) V.3(3/4)- 1981-
VCVGH* "Vrednie chemichescie veshestva, galogenproisvodnie uglevodorodov". (Hazardous substances: Galogenated hydrocarbons) Bandman A.L. et al., Chimia, 1990.

Used as brominated lame retardants and a fire-extinguishing agent

NIOSH PROFILE (ALIPHATICS, BROMINATED), SRI, 2/77

RTECS Compound Description:
   Drug
   Mutagen

ALT CAS #: 83847-49-8
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