The Registry of Toxic Effects of Chemical Substances

Methanearsonic acid

RTECS #: PA1575000

CAS #: 124-58-3

UPDATE: November 2004 MW: 139.98 MF: CH5AsO3


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. Kyselina methylarsonova (Czech)
  2. Methylarsenic acid
  3. Methylarsinic acid
  1. Methylarsonic acid
  2. Monomethylarsinic acid


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis human fibroblast 1,400 µmol/L MUREAV 357,123,1996


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lethal dose (50 percent kill): 1,800 mg/kg N/R JAFCAU 45,449,1997
oral
rat 		lethal dose (50 percent kill): 961 mg/kg N/R FAATDF 7,299,1986
subcutaneous
mouse 		lethal dose (50 percent kill): 794 mg/kg N/R 85JCAE -,1265,1986


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lowest published toxic dose: 13,440 mg/kg/4 week- intermittent Gastrointestinal: Hypermotility, diarrhea

Gastrointestinal: Other changes 		TXCYAC 190,197,2003
oral
rat 		lowest published toxic dose: 1,596 mg/kg/4 week- intermittent Gastrointestinal: Hypermotility, diarrhea

Gastrointestinal: Other changes 		TXCYAC 190,197,2003
oral
rat 		lowest published toxic dose: 19,110 mg/kg/42 week- intermittent Gastrointestinal: Hypermotility, diarrhea

Gastrointestinal: Other changes

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		TXCYAC 190,197,2003


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
TOXICOLOGY REVIEW
TOLED5 133,1,2002


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 0.5 mg(As)/m3 DTLVS* 3,16,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 0.5 mg(As)/m3 CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 0.5 mg(As)/m3 CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 0.5 mg(As)/m3 CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 0.5 mg(As)/m3 CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - ARAB Republic of Egypt time-weighted average 0.2 mg(As)/m3, JAN1993
Occupational Exposure Limit - AUSTRALIA time-weighted average 0.05 mg(As)/m3, Carcinogen, JAN1993
Occupational Exposure Limit - BELGIUM time-weighted average 0.2 mg(As)/m3, JAN1993
Occupational Exposure Limit - FINLAND Carcinogen, JAN1999
Occupational Exposure Limit - FRANCE VME 0.2 mg(As)/m3, JAN1993
Occupational Exposure Limit - HUNGARY short term exposure limit 0.5 mg(As)/m3, Carcinogen, JAN1993
Occupational Exposure Limit - INDIA time-weighted average 0.2 mg(As)/m3, JAN1993
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 0.5 mg(As)/m3, JAN1993
Occupational Exposure Limit - POLAND MAC(time-weighted average) 0.3 mg(As)/m3, JAN1993
Occupational Exposure Limit - SWEDEN NGV 0.03 mg(As)/m3, Carcinogen, JAN1999
Occupational Exposure Limit - SWITZERLAND MAK- week 0.1 mg(As)/m3, Carcinogen, JAN1999
Occupational Exposure Limit - THAILAND time-weighted average 0.5 mg(As)/m3, JAN1993
Occupational Exposure Limit - TURKEY time-weighted average 0.5 mg(As)/m3, JAN1993
Occupational Exposure Limit - UNITED KINGDOM LTEL 0.2 mg(As)/m3, JAN1993
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
N/R N/R N/R


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Arsenic, organo-, 5022


REFERENCES:

CODEN
REFERENCE
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information, see TOSCF2
JAFCAU Journal of Agricultural and Food Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) V.1- 1953-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973-

RTECS Compound Description:
   Agricultural Chemical
   Mutagen

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