The Registry of Toxic Effects of Chemical Substances

Methacrylic acid, methyl ester

RTECS #: OZ5075000

CAS #: 80-62-6

UPDATE: November 2004 MW: 100.13 MF: C5H8O2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. REPRODUCTIVE EFFECTS DATA:
  5. TUMORIGENIC DATA:
  6. ACUTE TOXICITY DATA:
  7. OTHER MULTIPLE DOSE DATA:
  8. REVIEWS:
  9. STANDARDS AND REGULATIONS:
  10. NIOSH DOCUMENTATION AND SURVEILLANCE:
  11. STATUS IN FEDERAL AGENCIES:
  12. REFERENCES:

SYNONYMS:

  1. 2 - (Methoxycarbonyl) - 1 - propene
  2. 2 - Methyl - 2 - propenoic acid methyl ester
  3. 2 - Propenoic acid, 2 - methyl - , methyl ester
  4. Acrylic acid, 2 - methyl - , methyl ester
  5. MME
  6. Metakrylan metylu (Polish)
  7. Methacrylate de methyle (French)
  8. Methacrylsaeuremethyl ester (German)
  9. Methyl 2 - methyl - 2 - propenoate
  10. Methyl alpha - methylacrylate
  11. Methyl methacrylate
  12. Methyl methacrylate (ACGIH:OSHA)
  1. Methyl methacrylate monomer
  2. Methyl methylacrylate
  3. Methyl - 2 - methyl - 2 - propenoate
  4. Methyl - 2 - methylpropenoate
  5. Methyl - methacrylat (German)
  6. Methylester kyseliny methakrylove (Czech)
  7. Methylmethacrylaat (Dutch)
  8. Metil metacrilato (Italian)
  9. NCI - C50680
  10. Pegalan
  11. RCRA waste number U162


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		150 mg N/R INMEAF 14,292,1945
skin
rabbit 		10 gm open irritation test N/R JIHTAB 23,343,1941


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis hamster ovary 1,600 mg/L NTPTR* NTP-TR-314,1986
cytogenetic analysis mouse lymphocyte 2,799 mg/L EMMUEG 11,49,1988
cytogenetic analysis mouse lymphocyte 2,202 mg/L MUREAV 222,191,1989
cytogenetic analysis inhalation
rat 		4 mg/m3/16 week BZARAZ 27(6),102,1974
mutation in microorganisms mouse lymphocyte 500 mg/L (+enzymatic activation step) ENMUDM 8(Suppl 6),4,1986
mutation in microorganisms Salmonella typhimurium 34 mmol/L (-enzymatic activation step) JBJSA3 61A,1203,1979
micronucleus test mouse lymphocyte 2,202 mg/L MUREAV 222,191,1989
mutation in mammalian somatic cells mouse lymphocyte 704 mg/L NTPTR* NTP-TR-314,1986
sister chromatid exchange hamster ovary 1,500 mg/L NTPTR* NTP-TR-314,1986


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mouse 		lowest published toxic concentration: 116 ppm/6 hour (4-13 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system 		NTIS** OTS0555600
inhalation
rat 		lowest published toxic concentration: 109 gm/m3/17 minute (6-15 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system 		TXAPA9 50,451,1979
inhalation
rat 		lowest published toxic concentration: 109 gm/m3/54 minute (6-15 day pregnant) Reproductive: Effects on embryo or fetus: Fetal death

Reproductive: Other developmental abnormalities 		TXAPA9 50,451,1979
inhalation
rat 		lowest published toxic concentration: 54 mg/m3/24 hour (8 week prior to copulation) Reproductive: Maternal effects: Menstrual cycle changes or disorders GTPZAB 21(2),49,1977
inhalation
rat 		lowest published toxic concentration: 4,480 mg/m3/2 hour (6-18 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) TOLED5 31(Suppl),80,1986
inhalation
rat 		lowest published toxic concentration: 500 mg/m3 (122 day prior to copulation) Reproductive: Other developmental abnormalities PREND* 37,51,1991
inhalation
rat 		lowest published toxic concentration: 500 mg/m3 (119 day prior to copulation) Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)

Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Other developmental abnormalities 		PROEAS 37,51,1991
inhalation
rat 		lowest published toxic concentration: 500 mg/m3 (98 day prior to copulation/21 day pregnant) Reproductive: Other developmental abnormalities PROEAS 37,51,1991
inhalation
woman 		lowest published toxic concentration: 10 mg/m3 (9 year pregnant) Reproductive: Other effects on female

Reproductive: Effects on embryo or fetus: Extra embryonic structures (e.g., placenta, umbilical cord)

Reproductive: Effects on newborn: Delayed effects 		GISAAA 62(4),19,1997
intraperitoneal
rat 		lowest published toxic dose: 405 mg/kg (5-15 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Other developmental abnormalities 		JDREAF 51,1632,1972
intraperitoneal
rat 		lowest published toxic dose: 801 mg/kg (5-15 day pregnant) Reproductive: Other developmental abnormalities JDREAF 51,1632,1972


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
implant
rat 		lowest published toxic dose: 1,620 mg/kg Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Tumorigenic: Tumors at site of application 		CORTBR 88,223,1972


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
dog 		lowest published lethal concentration: 41,200 mg/m3/3 hour Behavioral: Somnolence (general depressed activity)

Behavioral: Ataxia

Gastrointestinal: Changes in structure or function of salivary glands 		INMEAF 14,292,1945
inhalation
guinea pig 		lowest published lethal concentration: 19,000 mg/m3/5 hour Behavioral: Muscle weakness

Behavioral: Coma

Lung, Thorax, or Respiration: Respiratory depression 		JIHTAB 23,343,1941
inhalation
human 		lowest published toxic concentration: 125 ppm Behavioral: Sleep

Behavioral: Excitement

Behavioral: Anorexia (human) 		GISAAA 19(10),25,1954
inhalation
human 		lowest published toxic concentration: 60 mg/m3 Behavioral: Sleep

Behavioral: Excitement

Vascular: BP lowering not characterized in autonomic section 		GTPZAB 1,56,1957
inhalation
mammal (species unspecified) 		lethal concentration (50 percent kill): 20 gm/m3 N/R GISAAA 51(5),61,1986
inhalation
mouse 		lethal concentration (50 percent kill): 18,500 mg/m3/2 hour N/R GTPZAB 20(6),5,1976
inhalation
rat 		lethal concentration (50 percent kill): 78,000 mg/m3/4 hour N/R GTPZAB 20(6),5,1976
inhalation
rabbit 		lowest published lethal concentration: 17,500 mg/m3/4.5 hour Behavioral: Muscle weakness

Behavioral: Coma

Lung, Thorax, or Respiration: Respiratory depression 		JIHTAB 23,343,1941
intraperitoneal
guinea pig 		lethal dose (50 percent kill): 1,890 mg/kg Behavioral: Somnolence (general depressed activity) INMEAF 14,292,1945
intraperitoneal
mouse 		lethal dose (50 percent kill): 945 mg/kg Behavioral: Somnolence (general depressed activity) INMEAF 14,292,1945
intraperitoneal
rat 		lethal dose (50 percent kill): 1,328 mg/kg N/R JDREAF 51,1632,1972
intravenous
dog 		lowest published lethal dose: 120 µL/kg N/R JPMSAE 63,376,1974
oral
dog 		lethal dose (50 percent kill): 4,725 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Ataxia

Gastrointestinal: Changes in structure or function of salivary glands 		INMEAF 14,292,1945
oral
guinea pig 		lethal dose (50 percent kill): 5,954 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Ataxia

Gastrointestinal: Changes in structure or function of salivary glands 		INMEAF 14,292,1945
oral
mouse 		lethal dose (50 percent kill): 3,625 mg/kg N/R GISAAA 41(4),6,1976
oral
rat 		lethal dose (50 percent kill): 7,872 mg/kg Behavioral: Muscle weakness

Behavioral: Coma

Lung, Thorax, or Respiration: Respiratory depression 		JIHTAB 23,343,1941
oral
rabbit 		lethal dose (50 percent kill): 8,700 mg/kg N/R GISAAA 41(4),6,1976
subcutaneous
cat 		lowest published lethal dose: 7 mL/kg Peripheral Nerve and Sensation: Spastic paralysis with/without sensory change

Kidney, Ureter, and Bladder: Changes primarily in glomeruli

Biochemical: Metabolism (intermediary): Porphyrin including bile pigments 		NTIS** OTS0520933
subcutaneous
dog 		lethal dose (50 percent kill): 4,252 mg/kg Behavioral: Somnolence (general depressed activity) INMEAF 14,292,1945
subcutaneous
guinea pig 		lethal dose (50 percent kill): 5,954 mg/kg Behavioral: Somnolence (general depressed activity) INMEAF 14,292,1945
subcutaneous
mouse 		lethal dose (50 percent kill): 5,954 mg/kg Behavioral: Somnolence (general depressed activity) INMEAF 14,292,1945
subcutaneous
rat 		lethal dose (50 percent kill): 7,088 mg/kg Behavioral: Somnolence (general depressed activity) INMEAF 14,292,1945
subcutaneous
rabbit 		lowest published lethal dose: 14 mL/kg Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Other changes

Kidney, Ureter, and Bladder: Hematuria 		NTIS** OTS0520933
skin
rabbit 		lethal dose (50 percent kill): >5 gm/kg Skin: After systemic exposure: Dermatitis, other NTIS** OTS0544282


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
cat 		lowest published toxic concentration: 15 gm/m3/7 hour/5 day- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field NTIS** OTS0520933
inhalation
dog 		lowest published toxic concentration: 47 gm/m3/90 minute/15 day- intermittent Liver: Fatty liver degeneration

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		INMEAF 14,292,1945
inhalation
guinea pig 		lowest published toxic concentration: 65 gm/m3/3 hour/3 day- intermittent Liver: Fatty liver degeneration

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		INMEAF 14,292,1945
inhalation
hamster 		lowest published toxic concentration: 400 ppm/6 hour/78 week- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		NTIS** OTS0521056
inhalation
mouse 		lowest published toxic concentration: 41 gm/m3/90 minute/15 day- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field INMEAF 14,292,1945
inhalation
mouse 		lowest published toxic concentration: 5,000 ppm/6 hour/14 week- intermittent Olfaction: Other olfaction effects

Liver: Hepatitis (hepatocellular necrosis), zonal

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		NTPTR* NTP-TR-314,1986
inhalation
mouse 		lowest published toxic concentration: 500 ppm/6 hour/2 year- intermittent Olfaction: Other olfaction effects

Lung, Thorax, or Respiration: Fibrosis, focal (pneumoconiosis) 		TXCYAC 52,237,1988
inhalation
mouse 		lowest published toxic concentration: 30,900 mg/kg/103 week- intermittent Reproductive: Tumorigenic effects: Uterine tumors

Tumorigenic: Active as anti-cancer agent 		NTIS** PB87-146742/AS
inhalation
rat 		lowest published toxic concentration: 116 ppm/8 hour/26 week- intermittent Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Nutritional and Gross Metabolic: Changes in: P

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases 		ENVRAL 11,66,1976
inhalation
rat 		lowest published toxic concentration: 5,000 ppm/6 hour/14 week- intermittent Brain and Coverings: Changes in circulation

Olfaction: Other olfaction effects

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		NTPTR* NTP-TR-314,1986
inhalation
rat 		lowest published toxic concentration: 34,500 mg/m3/16 week- intermittent Liver: Fatty liver degeneration

Kidney, Ureter, and Bladder: Other changes

Biochemical: Metabolism (intermediary): Amino acids (including renal excretion) 		GISAAA 45(10),74,1980
inhalation
rat 		lowest published toxic concentration: 1 mg/m3/24 hour/60 day- continuous Behavioral: Muscle contraction or spasticity

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase

Biochemical: Metabolism (intermediary): Porphyrin including bile pigments 		GISAAA 27(11),3,1962
inhalation
rat 		lowest published toxic concentration: 115 mg/m3/3 hour/17 week- intermittent Cardiac: EKG changes not diagnostic of above

Blood: Other changes 		GISAAA 45(1),34,1980
inhalation
rat 		lowest published toxic concentration: 500 ppm/6 hour/2 year- intermittent Olfaction: Other olfaction effects

Lung, Thorax, or Respiration: Fibrosis, focal (pneumoconiosis) 		TXCYAC 52,237,1988
inhalation
rat 		lowest published toxic concentration: 50 mg/m3/4 hour/4 week- intermittent Endocrine: Change in LH

Endocrine: Change in gonadotropins

Related to Chronic Data: Changes in ovarian weight 		PROEAS 37,51,1991
inhalation
rat 		lowest published toxic concentration: 50 mg/m3/4 hour/17 week- intermittent Brain and Coverings: Other degenerative changes PROEAS 37,51,1991
inhalation
rat 		lowest published toxic concentration: 15,450 mg/kg/103 week- intermittent Brain and Coverings: Tumors

Tumorigenic: Active as anti-cancer agent 		NTIS** PB87-146742/AS
inhalation
rat 		lowest published toxic concentration: 50 mg/m3/4 hour/30 day- intermittent Endocrine: Change in LH

Endocrine: Change in gonadotropins

Related to Chronic Data: Changes in ovarian weight 		PREND* 37,51,1991
inhalation
rat 		lowest published toxic concentration: 500 mg/m3/4 hour/122 day- intermittent Endocrine: Other changes PREND* 37,51,1991
inhalation
rabbit 		lowest published toxic concentration: 15 gm/m3/7 hour/5 day- intermittent Kidney, Ureter, and Bladder: Other changes in urine composition

Biochemical: Metabolism (intermediary): Porphyrin including bile pigments 		NTIS** OTS0520933
intraperitoneal
mouse 		lowest published toxic dose: 19,665 mL/kg/15 week- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field JBMRBG 8,11,1974
oral
dog 		lowest published toxic dose: 1,825 mg/kg/2 year- continuous Endocrine: Changes in spleen weight TXAPA9 6,29,1964
oral
rat 		lowest published toxic dose: 10,500 mg/kg/21 day- intermittent Peripheral Nerve and Sensation: Structural change in nerve or sheath

Behavioral: Somnolence (general depressed activity)

Biochemical: Metabolism (intermediary): Lipids including transport 		INHEAO 27,121,1989
oral
rat 		lowest published toxic dose: 17,896 mg/kg/35 week- intermittent Gastrointestinal: Ulceration or bleeding from stomach

Liver: Other changes 		AMPMAR 32,653,1971
oral
rabbit 		lowest published toxic dose: 97,500 µg/kg/39 week- intermittent Brain and Coverings: Other degenerative changes

Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases 		GISAAA 41(4),6,1976


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 50 ppm DTLVS* TLV/BEI,2002
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 50 ppm (sen);short term exposure limit 100 ppm (sen) DTLVS* TLV/BEI,2003
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Not Classifiable as a Human Carcinogen DTLVS* TLV/BEI,2003
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value short term exposure limit 100 ppm DTLVS* TLV/BEI,2002
International Agency for Research on Cancer (IARC) Cancer Review Animal Inadequate Evidence IMEMDT 19,187,1979
International Agency for Research on Cancer (IARC) Cancer Review Human No Adequate Data IMEMDT 19,187,1979
International Agency for Research on Cancer (IARC) Cancer Review Human Inadequate Evidence IMEMDT 60,445,1994
International Agency for Research on Cancer (IARC) Cancer Review Animal LACK CARCINOGENICITY IMEMDT 60,445,1994
International Agency for Research on Cancer (IARC) Cancer Review Group 3 IMEMDT 60,445,1994
TOXICOLOGY REVIEW
MUREAV 566,21,2004
TOXICOLOGY REVIEW
CMTVAS 10(3),49,1973
TOXICOLOGY REVIEW
TOLED5 138,9,2003
TOXICOLOGY REVIEW
MUREAV 543,201,2003


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 100 ppm (410 mg/m3) DTLVS* 3,168,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 100 ppm (410 mg/m3) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 100 ppm (410 mg/m3) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 100 ppm (410 mg/m3) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 100 ppm (410 mg/m3) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 100 ppm (410 mg/m3), JAN1993
Occupational Exposure Limit - AUSTRIA MAK 50 ppm (210 mg/m3), JAN1999
Occupational Exposure Limit - BELGIUM time-weighted average 100 ppm (410 mg/m3), JAN1993
Occupational Exposure Limit - FINLAND time-weighted average 100 ppm (410 mg/m3), short term exposure limit 150 ppm (615 mg/m3), JAN1999
Occupational Exposure Limit - FRANCE VME 100 ppm (410 mg/m3), VLE 200 ppm (820 mg/m3), JAN1999
Occupational Exposure Limit - GERMANY MAK 50 ppm (210 mg/m3), JAN1999
Occupational Exposure Limit - HUNGARY time-weighted average 50 mg/m3, short term exposure limit 150 mg/m3, JAN1993
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 40 mg/m3, 2003
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 100 ppm (410 mg/m3), JAN1993
Occupational Exposure Limit - POLAND MAC(time-weighted average) 50 mg/m3, MAC(short term exposure limit) 400 mg/m3, JAN1999
Occupational Exposure Limit - RUSSIA short term exposure limit 10 mg/m3, JAN1993
Occupational Exposure Limit - SWEDEN NGV 50 ppm (200 mg/m3), KTV 150 ppm (600 mg/m3), Skin, JAN1999
Occupational Exposure Limit - SWITZERLAND MAK- week 50 ppm (210 mg/m3), KZG- week 100 ppm (420 mg/m3),JAN1999
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 50 ppm (208 mg/m3), short term exposure limit 100 ppm, SEP2000
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

short term exposure limit 100 ppm
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
short term exposure limit 100 ppm


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO METHYL METHACRYLATE-air 10 hour time-weighted average 100 ppm NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 47700;
Number of Industries 89;
Total Number of Facilities 11,522;
Number of Occupations 73;
Total Number of Employees Exposed 89,435
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 47700;
Number of Industries 76;
Total Number of Facilities 6,757;
Number of Occupations 80;
Total Number of Employees Exposed 170,079;
Total Number of Female Employees Exposed 59,519


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULE FEREAC 47,26992,82
Used as a chemical intermediate in the plastics industry
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Methyl methacrylate, 2537
NCI Carcinogenesis Studies (inhal);no evidence:mouse,rat
OSHA ANALYTICAL METHOD #94


REFERENCES:

CODEN
REFERENCE
AMPMAR Archives des Maladies Professionnelles de Medecine du Travail et de Securite Sociale. (SPPIF, B.P.22, F-41353 Vineuil, France) V.7- 1946-
BZARAZ Biologicheskii Zhurnal Armenii. Biological Journal of Armenia. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.19- 1966-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
CMTVAS Cahiers de Medecine du Travail. (Association Professionnelle Belge des Medecine du Travail, rue du Bultia, 6280 Gerpinnes, Belgium) V.1- 1963-
CORTBR Clinical Orthopaedics and Related Research. (Lippincott/Harper, Journal Fulfillment Dept., 2350 Virginia Ave., Hagerstown, MD 21740) No.26- 1963-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG.
ENVRAL Environmental Research. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1967-
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
INHEAO Industrial Health. (National Institute of Industrial Health, 6-21-1 Nagao, Tama-ku, Kawasaki, 213 Japan) V.1- 1963-
INMEAF Industrial Medicine. (Chicago, IL) V.1-18, 1932-49. For publisher information, see IOHSA5.
JBJSA3 Journal of Bone and Joint Surgery, American Volume. (10 Shattuck St., Boston, MA 02115) V.30- 1948-
JBMRBG Journal of Biomedical Materials Research. (John Wiley & Sons, Inc., 605 Third Ave., New York, NY 10158) V.1- 1967-
JDREAF Journal of Dental Research. (International Assoc. for Dental Research, 734 15th St., NW, Suite 809, Washington, DC 20005) V.1- 1919-
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU.
JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206-
PREND* Problemi Endocrinologii. (Endocrinology problems, 117819, Nauchnii proesd, 6, Moscow, Russia) V36- 1991-
PROEAS Problemy Endokrinologii. Problems of Endocrinology. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-6, 1936-41; 13- 1967-
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973-

Used as a chemical intermediate in the plastics industry

RTECS Compound Description:
   Tumorigen
   Mutagen
   Reproductive Effector
   Human Data
   Primary Irritant

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