The Registry of Toxic Effects of Chemical Substances

Methacrylic acid, butyl ester

RTECS #: OZ3675000

CAS #: 97-88-1

UPDATE: November 2004 MW: 142.22 MF: C8H14O2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. 2 - Methyl - butylacrylaat (Dutch)
  2. 2 - Methyl - butylacrylat (German)
  3. 2 - Methyl - butylacrylate
  4. 2 - Propenoic acid, 2 - methyl - , butyl ester
  5. Butil metacrilato (Italian)
  6. Butyl 2 - methacrylate
  7. Butyl 2 - methyl - 2 - propenoate
  1. Butyl methacrylate
  2. Butylester kyseliny methakrylove (Czech)
  3. Butylmethacrylaat (Dutch)
  4. Methacrylate de butyle (French)
  5. Methacrylsaeurebutylester (German)
  6. n - Butyl methacrylate
  7. n - Butylmethacrylate


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
skin
rabbit 		500 µL mild NTIS** OTS0538268


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published toxic concentration: 600 ppm/6 hour (6-20 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) TOSCF2 50,136,1999
intraperitoneal
rat 		lowest published toxic dose: 2,304 mg/kg (5-15 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) JDREAF 51,1632,1972
intraperitoneal
rat 		lowest published toxic dose: 690 mg/kg (5-15 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Other developmental abnormalities 		JDREAF 51,1632,1972


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mouse 		lethal concentration : >17 gm/m3/7.6 hour N/R JBMRBG 8,11,1974
inhalation
rat 		lethal concentration (50 percent kill): 4,910 ppm/4 hour Olfaction: Other olfaction effects

Eye: Other eye effects

Lung, Thorax, or Respiration: Dyspnea 		JTEHD6 16,811,1985
intraperitoneal
mouse 		lethal dose (50 percent kill): 1,490 mg/kg N/R JPMSAE 62,778,1973
intraperitoneal
rat 		lethal dose (50 percent kill): 2,304 mg/kg N/R JDREAF 51,1632,1972
intravenous
dog 		lowest published lethal dose: 166 µL/kg N/R JPMSAE 63,376,1974
oral
mouse 		lethal dose (50 percent kill): 12,900 mg/kg N/R GISAAA 41(4),6,1976
oral
rat 		lethal dose (50 percent kill): 16 gm/kg N/R GTPZAB 25(11),57,1981
oral
rabbit 		lethal dose (50 percent kill): 25 gm/kg N/R GISAAA 41(4),6,1976
skin
guinea pig 		lethal dose (50 percent kill): >20 mL/kg N/R NTIS** 0TS0516721
skin
rabbit 		lethal dose (50 percent kill): 11,300 µL/kg N/R AIHAAP 30,470,1969


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 107 gm/kg/17 week- intermittent Lung, Thorax, or Respiration: Changes in lung weight

Liver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		GTPZAB 19(9),57,1975
oral
rat 		lowest published toxic dose: 975 mg/kg/39 week- intermittent Brain and Coverings: Recordings from specific areas of CNS

Behavioral: Alteration of classical conditioning

Liver: Other changes 		GISAAA 41(4),6,1976
oral
rabbit 		lowest published toxic dose: 975 mg/kg/39 week- intermittent Blood: Pigmented or nucleated red blood cells

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Catalases 		GISAAA 41(4),6,1976


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
TOXICOLOGY REVIEW
EVHPAZ 11,141,1975


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Exposure Limit - DENMARK time-weighted average 50 ppm (290 mg/m3), JAN1999
Occupational Exposure Limit - RUSSIA short term exposure limit 30 mg/m3, JAN1993
Occupational Exposure Limit - SWEDEN NGV 50 ppm (300 mg/m3), KTV 75 ppm (450 mg/m3), JAN1999
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 59 mg/m3, 2003


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 84160;
Number of Industries 37;
Total Number of Facilities 1,231;
Number of Occupations 39;
Total Number of Employees Exposed 31,041
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 84160;
Number of Industries 16;
Total Number of Facilities 779;
Number of Occupations 19;
Total Number of Employees Exposed 10,001;
Total Number of Female Employees Exposed 2,931


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULE FEREAC 47,26992,82
Used in manufacture of coatings, resins and laquers
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958-
EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing Office, Supt of Documents, Washington, DC 20402) No.1- 1972-
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
JBMRBG Journal of Biomedical Materials Research. (John Wiley & Sons, Inc., 605 Third Ave., New York, NY 10158) V.1- 1967-
JDREAF Journal of Dental Research. (International Assoc. for Dental Research, 734 15th St., NW, Suite 809, Washington, DC 20005) V.1- 1919-
JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961-
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
TOSCF2 Toxicological Sciences (Oxford University Press, 6277 Sea Harbor Drive, Orlando, FL 32887 ) V. 41, Jan. 1998-

Used in manufacture of coatings, resins and laquers

NIOSH PROFILE (METHACRYLIC ACID AND ITS ESTERS), SRC, 12/79

RTECS Compound Description:
   Drug
   Reproductive Effector
   Primary Irritant

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