The Registry of Toxic Effects of Chemical Substances

Mesitylene

RTECS #: OX6825000

CAS #: 108-67-8

UPDATE: November 2004 MW: 120.21 MF: C9H12


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. Benzene, 1,3,5 - trimethyl -
  2. 3,5 - Dimethyltoluene
  3. Fleet - X
  1. 1,3,5 - Trimethylbenzene
  2. sym - Trimethylbenzene
  3. Trimethylbenzol


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		500 mg/24 hour mild 85JCAE -,34,1986
skin
rabbit 		20 mg/24 hour moderate 85JCAE -,34,1986


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
sister chromatid exchange intraperitoneal
mouse 		1,800 mg/kg MUREAV 412,299,1998


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
human 		lowest published toxic concentration: 10 ppm Peripheral Nerve and Sensation: Sensory change involving peripheral nerve

Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi 		ZUBEAQ 49,265,1956
inhalation
mouse 		lowest published toxic concentration: 15,000 mg/m3 Behavioral: Somnolence (general depressed activity) VCVGH* -,175,1990
inhalation
rat 		lethal concentration (50 percent kill): 24,000 mg/m3/4 hour N/R VCVGH* -,175,1990
inhalation
rat 		lethal concentration : 12,000 mg/m3/24 hour N/R VCVGH* -,175,1990
intraperitoneal
guinea pig 		lowest published lethal dose: 1,303 mg/kg N/R AMIHBC 9,227,1954
oral
mouse 		lethal dose (50 percent kill): 7,000 mg/kg N/R VCVGH* -,175,1990
oral
rat 		lethal dose (50 percent kill): 5,000 mg/kg N/R VCVGH* -,175,1990
oral
rat 		lethal dose (10 percent kill): 5 mL/kg N/R VCVGH* -,175,1990
subcutaneous
rat 		lowest published toxic dose: 12 mL/kg Blood: Changes in leukocyte (WBC) count VCVGH* -,175,1990


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published toxic concentration: 20 mg/m3/24 hour/17 week- intermittent Kidney, Ureter, and Bladder: Other changes in urine composition

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Catalases 		GISAAA 44(5),15,1979
inhalation
rat 		lowest published toxic concentration: 100 ppm/6 hour/20 day- intermittent Behavioral: Change in motor activity (specific assay)

Behavioral: Analgesia

Behavioral: Alteration of operant conditioning 		NRTXDN 22,79,2001
inhalation
rat 		lowest published toxic concentration: 20 mg/m3/16 week- continuous Kidney, Ureter, and Bladder: Other changes in urine composition VCVGH* -,176,1990
oral
rat 		lowest published toxic dose: 2,100 mg/kg/14 day- continuous Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) NTIS** OTS0558836
oral
rat 		lowest published toxic dose: 54 gm/kg/90 day- continuous Liver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Nutritional and Gross Metabolic: Changes in: P 		NTIS** OTS0558838
subcutaneous
rabbit 		lowest published toxic dose: 0.3 mL/kg/3 day- intermittent Blood: Changes in leukocyte (WBC) count VCVGH* -,176,1990


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Exposure Limit - DENMARK time-weighted average 25 ppm (120 mg/m3), JAN1999
Occupational Exposure Limit - GERMANY No MAK Established, JAN1999
Occupational Exposure Limit - JAPAN Occupational Exposure Limit 25 ppm (120 mg/m3), JAN1999
Occupational Exposure Limit - NORWAY time-weighted average 20 ppm (100 mg/m3), JAN1999
Occupational Exposure Limit - SWEDEN NGV 25 ppm (120 mg/m3), KTV 35 ppm (170 mg/m3), JAN1999
Occupational Exposure Limit - SWITZERLAND MAK- week 25 ppm (125 mg/m3), JAN1999
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 100 mg/m3, 2003
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: T1998;
Number of Industries 4;
Total Number of Facilities 495;
Number of Occupations 6;
Total Number of Employees Exposed 12,997;
Total Number of Female Employees Exposed 231


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as raw material in chemical synthesis and as ultraviolet stabilizer
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine. (Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU.
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NRTXDN Neurotoxicology. (Intox Press, Inc., POB 34075, Little Rock, AR 72203) V.1- 1979-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
VCVGH* "Vrednie chemichescie veshestva, galogenproisvodnie uglevodorodov". (Hazardous substances: Galogenated hydrocarbons) Bandman A.L. et al., Chimia, 1990.
ZUBEAQ Zeitschrift fuer Unfallmedizin und Berufskrankheiten. Revue de Medecine des Accidents et des Maladies Professionelles. (Verlag Berichthaus, Zwingliplatz 3, Postfach, CH-8022, Zurich, Switzerland) V.1- 1907-

Used as raw material in chemical synthesis and as ultraviolet stabilizer

NIOSH PROFILE (ARENES), SRI, 2/77

NIOSH PROFILE (TRIMETHYL BENZENES), SRC, 1/81

RTECS Compound Description:
   Mutagen
   Human Data
   Primary Irritant

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