RTECS:OW3010000 The Registry of Toxic Effects of Chemical Substances | CDC/NIOSH

The Registry of Toxic Effects of Chemical Substances

Mercury, dimethyl

RTECS #: OW3010000

CAS #: 593-74-8

UPDATE: August 2004 MW: 230.67 MF: C₂H₆Hg

NOTE:

TOXICITY DATA HAVE NOT BEEN EVALUATED. OMISSION OF A SUBSTANCE OR NOTATION DOES NOT IMPLY ANY RELIEF FROM REGULATORY RESPONSIBILITY.

TABLE OF CONTENTS:

SYNONYMS:

MUTATION DATA:

ACUTE TOXICITY DATA:

OTHER MULTIPLE DOSE DATA:

REVIEWS:

STANDARDS AND REGULATIONS:

STATUS IN FEDERAL AGENCIES:

REFERENCES:

SYNONYMS:

Dimethyl mercury

Methyl mercury

SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

MUTATION DATA AND REFERENCES:
SYSTEM TEST ROUTE/
ORGANISM/
TISSUE DOSE REFERENCE
cytogenetic analysis hamster ovary 40 mg/L MUREAV 290,281,1993
cytogenetic analysis human lymphocyte 43,400 nmol/L MUREAV 281,255,1992
DNA damage human lymphocyte 20 mg/L EMMUEG 22,172,1993
DNA damage other microorganisms 600 mg/L NATUAS 257,422,1975
DNA damage rat lymphocyte 20 mg/L EMMUEG 22,172,1993
DNA damage rat other cell types 20 mg/L EMMUEG 22,172,1993
other mutation test systems mouse other cell types 25 mg/L MUREAV 17,93,1973
sex chromosome loss and nondisjunction human lymphocyte 1,730 nmol/L MUREAV 281,255,1992

REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

TUMORIGENIC DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
intramuscular
mouse lowest published toxic dose: 1.4 mg/kg Brain and Coverings: Other degenerative changes

Blood: Other changes

Nutritional and Gross Metabolic: Changes in: Other metals TOXID9 72(Suppl 1),403,2003

OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
oral
mouse lowest published toxic dose: 48 mg/kg/14 day- intermittent Blood: Changes in spleen

Immunological Including Allergic: Increase in cellular immune response TOXID9 72,173,2003
unreported route
mouse lowest published toxic dose: 30 痢/kg/6 day- intermittent Blood: Changes in spleen

Immunological Including Allergic: Increase in cellular immune response TOXID9 72,376,2003

REVIEWS:
ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.01; short term exposure limit 0.03 mg/m³ (skin) DTLVS* TLV/BEI,1999
International Agency for Research on Cancer (IARC) Cancer Review Human Inadequate Evidence IMEMDT 58,239,1993
International Agency for Research on Cancer (IARC) Cancer Review Group 2B IMEMDT 58,239,1993
TOXICOLOGY REVIEW
CMAJAX 165,205,2001
TOXICOLOGY REVIEW
MUREAV 566,21,2004

STANDARDS AND REGULATIONS:
ORGANIZATION STANDARD
REFERENCE

Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 0.001 ppm (0.01 mg(Hg)/m³) DTLWS* 3,22,1973
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 0.01 mg(Hg)/m³ CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 0.01 mg(Hg)/m³ (skin) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 0.01 mg(Hg)/m³ (skin) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 0.01 mg(Hg)/m³ (skin) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 0.01 mg(Hg)/m³, short term exposure limit 0.03 mg(Hg)/m³, Skin, JAN1993
Occupational Exposure Limit - AUSTRIA MAK 0.01 mg(Hg)/m³, JAN1999
Occupational Exposure Limit - BELGIUM time-weighted average 0.01 mg(Hg)/m³, short term exposure limit 0.03 mg(Hg)/m³, Skin, JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 0.01 mg(Hg)/m³, Skin, JAN1999
Occupational Exposure Limit - FINLAND time-weighted average 0.01 mg(Hg)/m³, Skin, JAN1999
Occupational Exposure Limit - FRANCE VME 0.01 mg(Hg)/m³, Skin, JAN1999
Occupational Exposure Limit - GERMANY MAK 0.01 mg(Hg)/m³, JAN1999
Occupational Exposure Limit - NORWAY time-weighted average 0.01 mg(Hg)/m³, JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 0.01 mg(Hg)/m³, JAN1993
Occupational Exposure Limit - POLAND MAC(time-weighted average) 0.01 mg(Hg)/m³, MAC(short term exposure limit) 0.01 mg(Hg)/m³, JAN1999
Occupational Exposure Limit - SWEDEN NGV 0.01 mg(Hg)/m³, Skin, JAN1999
Occupational Exposure Limit - THAILAND time-weighted average 0.01 mg(Hg)/m³, short term exposure limit 0.04 mg(Hg)/m³, JAN1993
Occupational Exposure Limit - TURKEY time-weighted average 0.01 mg(Hg)/m³, Skin, JAN1993
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 0.01 mg(Hg)/m³, short term exposure limit 0.03 mg(Hg)/m³, Skin, SEP2000
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 0.01;
short term exposure limit 0.03 mg/m³ (skin)
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 0.01;
short term exposure limit 0.03 mg/m³ (skin)

NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION STANDARD or SURVEY
REFERENCE

N/R N/R N/R

STATUS IN FEDERAL AGENCIES:
ORGANIZATION
REFERENCE

EPA GENETOX PROGRAM 1988, Negative: In vivo cytogenetics-mammalian oocyte
EPA GENETOX PROGRAM 1988, Inconclusive: Rodent dominant lethal
EPA TSCA Section 8(b) CHEMICAL INVENTORY

REFERENCES:
CODEN
REFERENCE

CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
CMAJAX Canadian Medical Association Journal. (Canadian Medical Assoc., POB 8650, Ottawa, ON K1G 0G8, Canada) V.1- 1911-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
DTLWS* "Documentation of the Threshold Limit Values for Substances in Workroom Air," Supplements. For publisher information, see 85INA8.
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NATUAS Nature. (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736) V.1- 1869-
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-

RTECS Compound Description:
   Tumorigen
   Organometallic
   Mutagen

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