The Registry of Toxic Effects of Chemical Substances

Mercury, (acetato) phenyl -

RTECS #: OV6475000

CAS #: 62-38-4

UPDATE: May 2004 MW: 336.75 MF: C8H8HgO2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. REPRODUCTIVE EFFECTS DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. REVIEWS:
  8. STANDARDS AND REGULATIONS:
  9. NIOSH DOCUMENTATION AND SURVEILLANCE:
  10. STATUS IN FEDERAL AGENCIES:
  11. REFERENCES:

SYNONYMS:

  1. Acetic acid, phenylmercury deriv.
  2. Acetoxyphenylmercury
  3. (Acetoxymercuri) benzene
  4. Algimycin 200
  5. Anticon
  6. Antimucin WBR
  7. Antimucin WDR
  8. Benzene, (acetoxymercuri) -
  9. Contra Creme
  10. Dyanacide
  11. Femma
  12. Fenylmerkuriacetat (Czech)
  13. Fungicide R
  14. Fungitox OR
  15. Liquiphene
  16. Mercuron
  17. Mercury (II) acetate, phenyl -
  18. Acetate phenylmercurique (French)
  19. (Acetato) phenylmercury
  20. Bufen
  21. Bufen 30
  22. Ceresol
  23. Hexasan
  24. Hexasan (fungicide)
  25. Intercide 60
  26. Intercide PMA 18
  27. Lorophyn
  28. Mercuriphenyl acetate
  29. Mercury, acetoxyphenyl -
  30. Mergal A 25
  31. Mersolite D
  32. Mersolite 8
  33. Neantina
  34. Phenylquecksilberacetat (German)
  35. Phix
  36. Purasan - SC - 10
  37. Puraturf 10
  38. Quicksan
  1. Quicksan 20
  2. RCRA waste number P092
  3. Shimmerex
  4. Spor - Kil
  5. Spruce Seal
  6. Norforms
  7. Nuodex PMA 18
  8. Nylmerate
  9. Octan fenylrtutnaty (Czech)
  10. Panomatic
  11. Phenomercuric acetate
  12. Phenylmercuriacetate
  13. Phenyl mercuric acetate
  14. Phenylmercury acetate
  15. Phenylmercury (II) acetate
  16. PMAC
  17. PMA (fungicide)
  18. PMAS
  19. Programin
  20. Ruberon
  21. Samtol
  22. Sanitized SPG
  23. Scutl
  24. Seed Dressing R
  25. Seedtox
  26. Setrete
  27. Tag
  28. Tag 331
  29. Tag fungicide
  30. Tag HL 331
  31. Trigosan
  32. Troysan 30
  33. Troysan PMA 30
  34. Verdasan
  35. Volpar
  36. Zaprawa Nasienna R
  37. Ziarnik


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		50 µg/24 hour severe 85JCAE -,1205,1986
skin
human 		100 µg/24 hour severe ARDEAC 106,129,1972


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis oral
pig 		160 mg/kg/32 day- continuous VETNAL 52(8),91,1975
DNA inhibition mouse lymphocyte 1 µmol/L BCPCA6 24,489,1975
DNA repair Bacillus subtilis 50 mmol/L MUREAV 31,185,1975
DNA repair Bacillus subtilis 1 mmol/L MUREAV 77,109,1980
DNA repair Escherichia coli 2 mmol/L MJDHDW 28,F39,1980
other mutation test systems mouse lymphocyte 10 µmol/L BCPCA6 24,489,1975
sister chromatid exchange human lymphocyte 30 mg/L DBABEF 8,105,1984
sex chromosome loss and nondisjunction oral
Drosophila melanogaster 		200 ppm ENVRAL 36,218,1985


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mammal (species unspecified) 		lowest published toxic dose: 125 µg/kg (8 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) TXCYAC 6,281,1976
intravaginal
mouse 		lowest published toxic dose: 110 µg/kg (7 day pregnant) Reproductive: Effects on embryo or fetus: Fetal death

Reproductive: Specific developmental abnormalities: Musculoskeletal system 		ARINAU 3,88,1956
intravenous
hamster 		lowest published toxic dose: 7,500 µg/kg (8 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Homeostasis 		LSBGAY 10,1341,1971
intravenous
hamster 		lowest published toxic dose: 8 mg/kg (8 day pregnant) Reproductive: Specific developmental abnormalities: Central nervous system LSBGAY 10,1341,1971
oral
hamster 		lowest published toxic dose: 20 mg/kg (5 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) PARWAC 22,263,1980
oral
rat 		lowest published toxic dose: 15 mg/kg (6-10 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Homeostasis

Reproductive: Other developmental abnormalities 		PARWAC 22,263,1980
oral
rabbit 		lowest published toxic dose: 9 mg/kg (8-12 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Homeostasis

Reproductive: Other developmental abnormalities 		PARWAC 22,263,1980
subcutaneous
mouse 		lowest published toxic dose: 110 µg/kg (8 day pregnant) Reproductive: Effects on embryo or fetus: Fetal death ARINAU 3,88,1956


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mammal (species unspecified) 		lethal dose (50 percent kill): 10 mg/kg N/R TXCYAC 6,281,1976
intraperitoneal
mouse 		lethal dose (50 percent kill): 13 mg/kg N/R AMSVAZ 143,365,1952
intravenous
mouse 		lethal dose (50 percent kill): 18 mg/kg N/R CSLNX* NX#00921
oral
chicken 		lethal dose (50 percent kill): 60 mg/kg N/R TXAPA9 2,344,1960
oral
mouse 		lethal dose (50 percent kill): 13,250 µg/kg N/R YAKUD5 22,291,1980
oral
quail 		lethal dose (50 percent kill): 71 mg/kg N/R AXVMAW 34,383,1980
oral
rat 		lethal dose (50 percent kill): 41 mg/kg N/R ATDAEI 1,175,1992
subcutaneous
mouse 		lethal dose (50 percent kill): 12 mg/kg N/R TOIZAG 9,101,1962
unreported route
mammal (species unspecified) 		lethal dose (50 percent kill): 17 mg/kg N/R 30ZDA9 -,295,1971


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 91 mg/kg/13 week- continuous Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes 		ATSUDG 4,201,1980
oral
rat 		lowest published toxic dose: 346 mg/kg/1 year- continuous Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) AMIHBC 2,433,1950
oral
rat 		lowest published toxic dose: 5,840 mg/kg/2 year- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		HBPTO* 2,1380,2001
oral
rat 		lowest published toxic dose: 456.25 mg/kg/2 year- continuous Kidney, Ureter, and Bladder: Other changes HBPTO* 2,1380,2001


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.1 mg(Hg)/m3 (skin) DTLVS* TLV/BEI,1999
International Agency for Research on Cancer (IARC) Cancer Review Human Inadequate Evidence IMEMDT 58,239,1993
International Agency for Research on Cancer (IARC) Cancer Review Group 2B IMEMDT 58,239,1993
TOXICOLOGY REVIEW
AJOGAH 126,390,1976
TOXICOLOGY REVIEW
SDGTB3 1,177,1971
TOXICOLOGY REVIEW
BIOGAL 41(7),208,1975
TOXICOLOGY REVIEW
ADTEAS 5,51,1972


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Cancelled RBREV* -,199,1998
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 0.05 mg(Hg)/m3 DTLWS* 3,22,1973
Occupational Exposure Limit - AUSTRALIA time-weighted average 0.05 mg(Hg)/m3, Skin, JAN1993
Occupational Exposure Limit - BELGIUM time-weighted average 0.05 mg(Hg)/m3, Skin, JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 0.05 mg(Hg)/m3, Skin, JAN1999
Occupational Exposure Limit - FINLAND time-weighted average 1 mg(Hg)/m3, JAN1999
Occupational Exposure Limit - FRANCE VME 0.1 mg(Hg)/m3, Skin, JAN1999
Occupational Exposure Limit - GERMANY MAK 0.01 ppm (0.1 mg(Hg)/m3), JAN1999
Occupational Exposure Limit - HUNGARY time-weighted average 0.02 mg(Hg)/m3, short term exposure limit 0.04 mg(Hg)/m3, JAN1993
Occupational Exposure Limit - JAPAN Occupational Exposure Limit 0.05 mg(Hg)/m3, JAN1999
Occupational Exposure Limit - NORWAY time-weighted average 0.05 mg(Hg)/m3, JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 0.05 mg(Hg)/m3, JAN1993
Occupational Exposure Limit - POLAND MAC(time-weighted average) 0.05 mg(Hg)/m3, MAC(short term exposure limit) 0.15 mg(Hg)/m3, JAN1999
Occupational Exposure Limit - RUSSIA time-weighted average 0.05 mg(Hg)/m3, short term exposure limit 0.01 mg(Hg)/m3, JAN1993
Occupational Exposure Limit - SWEDEN NGV 0.05 mg(Hg)/m3, Skin, JAN1999
Occupational Exposure Limit - THAILAND short term exposure limit 0.05 mg(Hg)/m3, JAN1993
Occupational Exposure Limit - UNITED KINGDOM LTEL 0.05 mg(Hg)/m3, short term exposure limit 0.15 mg(Hg)/m3, JAN1993
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 0.1 mg(Hg)/m3 (skin)
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 0.1 mg(Hg)/m3 (skin)


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO MERCURY, ARYL AND INORGANIC-air ceiling concentration 0.1 mg/m3 (Sk) NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 57340;
Number of Industries 11;
Total Number of Facilities 588;
Number of Occupations 29;
Total Number of Employees Exposed 10,962
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 57340;
Number of Industries 27;
Total Number of Facilities 2,429;
Number of Occupations 30;
Total Number of Employees Exposed 28,342;
Total Number of Female Employees Exposed 5,150


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Positive: D melanogaster-whole sex chrom. loss
EPA GENETOX PROGRAM 1988, Positive: D melanogaster-nondisjunction; B subtilis rec assay
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used for fungal and bacterial control and control of crabgrass
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
30ZDA9 "Chemistry of Pesticides," Melnikov, N.N., New York, Springer-Verlag New York, Inc., 1971
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
ADTEAS Advances in Teratology. (New York, NY) V.1-5, 1966-72. Discontinued.
AJOGAH American Journal of Obstetrics and Gynecology. (C.V. Mosby Co., 11830 Westline Industrial Dr., St. Louis, MO 63146) V.1- 1920-
AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine. (Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU.
AMSVAZ Acta Medica Scandinavica. (Almqvist & Wiksell, POB 45150, S-10430 Stockholm, Sweden) V.52-224, 1919-88.
ARDEAC Archives of Dermatology. (AMA, 535 N. Dearborn St., Chicago, IL 60610) V.82- 1960-
ARINAU Annual Report of the Research Institute of Environmental Medicine, Nagoya University. (Nagoya, Japan) V.1-25, 1951-80.
ATDAEI Acute Toxicity Data. Journal of the American College of Toxicology, Part B. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1- 1990-
ATSUDG Archives of Toxicology, Supplement. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) No.1- 1978-
AXVMAW Archiv fuer Experimentelle Veterinaermedizin. (S. Hirzel Verlag, Postfach 506, Leipzig DDR-7010, Ger. Dem. Rep.) V.6- 1952-
BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958-
BIOGAL Biologico. (Instituto Biologica, Av. Cons. Rodriques Alves, 1252, CEP 04014, Sao Paulo, Brazil) V.1- 1935-
CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010)
DBABEF Doga Bilim Dergisi, Seri A2: Biyoloji. Natural Science Journal, Series A2. (Turkiye Bilimsel ve Teknik Arastirma Kurumu, Ataturk Bul. No. 221, Kavaklidere, Ankara, Turkey) V.8- 1984-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
DTLWS* "Documentation of the Threshold Limit Values for Substances in Workroom Air," Supplements. For publisher information, see 85INA8.
ENVRAL Environmental Research. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1967-
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
HBPTO* Handbook of pesticide toxicology. Robert Krieger ed, Academic press, 2001
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
LSBGAY Life Sciences, Part 2: Biochemistry, General and Molecular Biology. (New York, NY) V.9-13, 1970-73. For publisher information, see LIFSAK.
MJDHDW Mukogawa Joshi Daigaku Kiyo, Shokumotsu-hen. Bulletin of Mukogawa Women's University, Food Science Series. (Mukogawa Joshi Daigaku, 6-46, Ikebiraki-cho, Nishinomiya, Hyogo-ken, Japan) No.19- 1972-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
PARWAC Polskie Archiwum Weterynaryjne. Polish Archives of Veterinary Medicine. (Panstwowe Wydawnictwo Naukowe, POB 391, 00251 Warsaw, Poland) V.1- 1951-
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
SDGTB3 Seminars in Drug Treatment. (New York, NY) V.1-3, 1971-74. Discontinued.
TOIZAG Toho Igakkai Zasshi. Journal of Medical Society of Toho University. (Toho Daigaku Igakkai, 21-16, Omori-nishi, 5-chome, Ota-ku, Tokyo 143, Japan) V.1- 1954-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973-
VETNAL Veterinariya. Veterinary Science. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1924-
YAKUD5 Gekkan Yakuji. Pharmaceuticals Monthly. (Yakugyo Jihosha, Inaoka Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan) V.1- 1959-

Used for fungal and bacterial control and control of crabgrass

NIOSH PROFILE (ORGANIC MERCURY), SRC, 10/77

RTECS Compound Description:
   Agricultural Chemical
   Tumorigen
   Organometallic
   Mutagen
   Reproductive Effector
   Primary Irritant

ALT CAS #: 1337-06-0
ALT CAS #: 61840-45-7
ALT CAS #: 64684-45-3
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