The Registry of Toxic Effects of Chemical Substances

Manganese, monosulfate, monohydrate

RTECS #: OP0893500

CAS #: 10034-96-5

UPDATE: November 2004 MW: 169.02 MF: O4S•Mn•H2O


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. TUMORIGENIC DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. REVIEWS:
  8. STANDARDS AND REGULATIONS:
  9. NIOSH DOCUMENTATION AND SURVEILLANCE:
  10. STATUS IN FEDERAL AGENCIES:
  11. REFERENCES:

SYNONYMS:

  1. Manganese (II) sulfate monohydrate
  2. Manganese sulfate monohydrate
  3. Manganese (2+) sulfate monohydrate
  1. Manganous sulfate monohydrate
  2. Sulfuric acid, manganese (2+) salt (1:1) , monohydrate


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis hamster ovary 180 mg/L EMMUEG 10(Suppl 10),1,1987
cytogenetic analysis oral
mouse 		718 mg/kg/7 day- continuous MUREAV 240,159,1990
mutation in microorganisms Saccharomyes cerevisiae 40 µmol/L (-enzymatic activation step) MUREAV 137,47,1984
micronucleus test oral
mouse 		205 mg/kg/24 hour- continuous MUREAV 240,159,1990
gene conversion and mitotic recombination Saccharomyes cerevisiae 40 µmol/L MUREAV 137,47,1984
sister chromatid exchange hamster ovary 5 mg/L EMMUEG 10(Suppl 10),1,1987
sperm morphology oral
mouse 		513 mg/kg/5 day- continuous MUREAV 240,159,1990


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lowest published toxic dose: 513 mg/kg (5 day male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) MUREAV 240,159,1990


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lowest published toxic dose: 1,314 gm/kg/2 year- continuous Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Endocrine: Thyroid tumors 		NTPTR* NTP-TR-428,1993
oral
mouse 		lowest published toxic dose: 1,297,800 mg/kg/103 week- continuous Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Endocrine: Thyroid tumors 		NTIS** PB94-217148
oral
mouse 		lowest published toxic dose: 1,622,250 mg/kg/103 week- continuous Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Endocrine: Thyroid tumors 		NTIS** PB94-217148


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intravenous
rat 		lowest published toxic dose: 4.5 mg/kg Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects 		TOSCF2 73,378,2003


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lowest published toxic dose: 546 gm/kg/13 week- continuous Liver: Changes in liver weight

Blood: Pigmented or nucleated red blood cells

Blood: Other changes 		NTPTR* NTP-TR-428,1993
oral
rat 		lowest published toxic dose: 42 gm/kg/14 day- continuous Liver: Changes in liver weight

Blood: Changes in other cell count (unspecified)

Blood: Changes in leukocyte (WBC) count 		NTPTR* NTP-TR-428,1993
oral
rat 		lowest published toxic dose: 28,437 mg/kg/13 week- continuous Lung, Thorax, or Respiration: Changes in lung weight

Blood: Changes in leukocyte (WBC) count

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		NTPTR* NTP-TR-428,1993


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.2 mg(Mn)/m3 DTLVS* TLV/BEI,1999


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) ceiling concentration 5 mg(Mn)/m3 CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) ceiling concentration 5 mg(Mn)/m3 CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) ceiling concentration 5 mg(Mn)/m3 CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) ceiling concentration 5 mg(Mn)/m3 CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 5 mg(Mn)/m3, JAN1993
Occupational Exposure Limit - BELGIUM time-weighted average 5 mg(Mn)/m3, JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 2.5 mg(Mn)/m3, JAN1999
Occupational Exposure Limit - FINLAND time-weighted average 0.5 mg(Mn)/m3, JAN1999
Occupational Exposure Limit - HUNGARY time-weighted average 0.3 mg(Mn)/m3, short term exposure limit 0.6 mg(Mn)/m3, JAN1993
Occupational Exposure Limit - JAPAN Occupational Exposure Limit 0.3 mg(Mn)/m3, respirable dust, JAN1999
Occupational Exposure Limit - NORWAY time-weighted average 2.5 mg(Mn)/m3, JAN1999
Occupational Exposure Limit - POLAND MAC(time-weighted average) 0.3 mg(Mn)/m3, MAC( continuous) 5 mg(Mn)/m3, JAN1999
Occupational Exposure Limit - SWEDEN NGV 1 mg(Mn)/m3, TGV 2.5 mg(Mn)/m3 (resp. dust), JAN1993
Occupational Exposure Limit - SWEDEN NGV 2.5 mg(Mn)/m3, TGV 5 mg(Mn)/m3 (total dust), JAN1993
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 5 mg(Mn)/m3, SEP2000
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 0.2 mg(Mn)/m3
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 0.2 mg(Mn)/m3


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X1601;
Number of Industries 3;
Total Number of Facilities 60;
Number of Occupations 6;
Total Number of Employees Exposed 893;
Total Number of Female Employees Exposed 398


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
NCI Carcinogenesis Studies (feed);equivocal evidence:mouse
NCI Carcinogenesis Studies (feed);no evidence:rat


REFERENCES:

CODEN
REFERENCE
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206-
TOSCF2 Toxicological Sciences (Oxford University Press, 6277 Sea Harbor Drive, Orlando, FL 32887 ) V. 41, Jan. 1998-

RTECS Compound Description:
   Tumorigen
   Mutagen
   Reproductive Effector

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