The Registry of Toxic Effects of Chemical Substances

Manganese, (ethylenebis (dithiocarbamato) ) -

RTECS #: OP0700000

CAS #: 12427-38-2

UPDATE: February 2005 MW: 265.30 MF: C4H6N2S4•Mn


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. TUMORIGENIC DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. REVIEWS:
  8. STANDARDS AND REGULATIONS:
  9. NIOSH DOCUMENTATION AND SURVEILLANCE:
  10. STATUS IN FEDERAL AGENCIES:
  11. REFERENCES:

SYNONYMS:

  1. 1,2 - Ethanediylbis (carbamodithioato) (2 - ) - manganese
  2. 1,2 - Ethanediylbiscarbamodithioic acid, manganese complex
  3. 1,2 - Ethanediylbiscarbamodithioic acid, manganese (2+) salt (1:1)
  4. 1,2 - Ethanediylbismaneb, manganese (2+) salt (1:1)
  5. 1,2 - Ethylenediylbis (carbamodithioato) manganese
  6. AAmangan
  7. Agrox N - M
  8. Agrox flowable
  9. Akzo chemie maneb
  10. BASF - maneb spritzpulver
  11. Carbamic acid, ethylenebis (dithio - , manganese salt
  12. Carbamodithioic acid, 1,2 - ethanediylbis - , manganese complex
  13. Chloroble M
  14. Curzate M
  15. Delsene M
  16. Dithane M 22
  17. Dithane M 22 special
  18. ENT 14,875
  19. Ethylenebis (dithiocarbamato) , manganese
  20. Ethylenebis (dithiocarbamic acid) manganous salt
  21. Ethylenebis (dithiocarbamic acid) , manganese salt
  22. Ethylenebisdithiocarbamate manganese
  23. F 10 (Pesticide)
  24. Griffin manex
  25. Kypman 80
  26. Lonocol M
  27. Luxan maneb 80
  28. Maneb
  29. Maneb 80
  30. Maneb ZL4
  1. Maneba
  2. Manebe (French)
  3. Manebe 80
  4. Manebgan
  5. Manesan
  6. Manex
  7. Mangaan (II) - (N,N' - ethyleen - bis (dithiocarbamaat) ) (Dutch)
  8. Mangan (II) - (N,N' - aethylen - bis (dithiocarbamate) ) (German)
  9. Mangan (II) - (N,N - aethylen - bis (dithiocarbamat) ) (German)
  10. Manganese (II) ethylene di (dithiocarbamate)
  11. Manganese ethylene - 1,2 - bisdithiocarbamate
  12. Manganous ethylenebis (dithiocarbamate)
  13. Manganous ethylenebisdithiocarbamate
  14. Manzate
  15. Manzate D
  16. Manzate maneb fungicide
  17. N,N' - Ethylene bis (dithiocarbamate manganeux) (French)
  18. N,N' - Etilen - bis (ditiocarbammato) di manganese (Italian)
  19. Nereb
  20. Nespor
  21. Plantifog 160M
  22. Polyram M
  23. Remasan chloroble M
  24. Rhodianebe
  25. Trimangol
  26. Trimangol 80
  27. Tritogol M
  28. Tubothane
  29. Unicrop maneb
  30. Vancide maneb 80


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis hamster lung 31 mg/L GMCRDC 27,95,1981
DNA inhibition human lymphocyte 10 mg/L ARTODN 45,101,1980
DNA inhibition rat other cell types 10 mg/L ARTODN 45,101,1980
unscheduled DNA synthesis human fibroblast 10 mg/L NTIS** PB85-193761
mutation in microorganisms other microorganisms 1,000 ppm (-enzymatic activation step) MMAPAP 50,233,1973
mutation in microorganisms Saccharomyes cerevisiae 5 ppm (-enzymatic activation step) RSTUDV 6,161,1976
gene conversion and mitotic recombination oral
Drosophila melanogaster 		0.75 mmol/L/48 hour MUREAV 518,95,2002
gene conversion and mitotic recombination Saccharomyes cerevisiae 40 ppm NTIS** PB85-193761
sister chromatid exchange chicken embryo 14 gm/L MUREAV 206,271,1988


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lowest published toxic dose: 15 mg/kg (15 day after birth) Reproductive: Specific developmental abnormalities: Central nervous system NRTXDN 23,621,2002
oral
mouse 		lowest published toxic dose: 3,750 mg/kg (7-16 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system JTEHD6 5,821,1979
oral
mouse 		lowest published toxic dose: 10 gm/kg (8-12 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)

Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive) 		TCMUD8 7,7,1987
oral
mouse 		lowest published toxic dose: 12 gm/kg (6-15 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Effects on embryo or fetus: Fetal death

Reproductive: Specific developmental abnormalities: Musculoskeletal system 		REPTED 4,283,1990
oral
rat 		lowest published toxic dose: 7,440 mg/kg (7-22 day pregnant/15 day after birth) Reproductive: Other effects on female

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)

Reproductive: Effects on newborn: Physical 		JTEHD6 5,821,1979
oral
rat 		lowest published toxic dose: 770 mg/kg (11 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Specific developmental abnormalities: Body wall

Reproductive: Specific developmental abnormalities: Central nervous system 		TJADAB 14,171,1976
oral
rat 		lowest published toxic dose: 770 mg/kg (11 day pregnant) Reproductive: Specific developmental abnormalities: Eye, ear

Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)

Reproductive: Specific developmental abnormalities: Musculoskeletal system 		TJADAB 14,171,1976
oral
rat 		lowest published toxic dose: 770 mg/kg (11 day pregnant) Reproductive: Specific developmental abnormalities: Homeostasis TJADAB 14,171,1976
oral
rat 		lowest published toxic dose: 1,420 mg/kg (11 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) TJADAB 14,171,1976
oral
rat 		lowest published toxic dose: 2,500 mg/kg (6-22 day pregnant) Reproductive: Other effects on female

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)

Reproductive: Effects on newborn: Biochemical and metabolic 		TOLED5 99,91,1998


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
implant
rat 		lowest published toxic dose: 50 mg/kg Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Endocrine: Thyroid tumors

Skin and Appendages: Tumors 		VPITAR 29,71,1970
oral
mouse 		lowest published toxic dose: 3,600 mg/kg/5 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors 		GISAAA 37(9),25,1972
oral
rat 		lowest published toxic dose: 62,980 mg/kg/94 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Gastrointestinal: Tumors

Skin and Appendages: Tumors 		VPITAR 29,71,1970


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
rat 		lowest published toxic dose: 20 mg/kg Endocrine: Other changes ATSUDG Suppl.8,253,1985
oral
guinea pig 		lowest published lethal dose: 6,400 mg/kg N/R PCOC** -,675,1966
oral
mouse 		lethal dose (50 percent kill): 2,600 mg/kg N/R GISAAA 36(5),22,1971
oral
rat 		lethal dose (50 percent kill): 3 gm/kg N/R GISAAA 36(5),22,1971
skin
rat 		lethal dose (50 percent kill): >5 gm/kg N/R 85JFAN A252,1983
unreported route
mammal (species unspecified) 		lethal dose (50 percent kill): 5 gm/kg N/R GISAAA 45(5),29,1980
unreported route
quail 		lethal dose (50 percent kill): 467 mg/kg N/R FMCHA2 -,C189,1991
unreported route
rat 		lethal dose (50 percent kill): 3 gm/kg N/R EQSSDX 3,618,1975


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lowest published toxic dose: 15 mg/kg/15 day- intermittent Brain and Coverings: Other degenerative changes

Biochemical: Neurotransmitters or modulators (putative): Dopamine in striatum 		NRTXDN 23,621,2002
intraperitoneal
mouse 		lowest published toxic dose: 915 mg/kg/45 day- intermittent Brain and Coverings: Other degenerative changes

Biochemical: Neurotransmitters or modulators (putative): Dopamine in striatum 		NRTXDN 23,621,2002
intraperitoneal
mouse 		lowest published toxic dose: 15 mg/kg/15 day- intermittent Brain and Coverings: Other degenerative changes NRTXDN 23,621,2002


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
International Agency for Research on Cancer (IARC) Cancer Review Animal Inadequate Evidence IMEMDT 12,137,1976
International Agency for Research on Cancer (IARC) Cancer Review Human No Adequate Data IMEMDT 12,137,1976
International Agency for Research on Cancer (IARC) Cancer Review Group 3 IMSUDL 7,56,1987
TOXICOLOGY REVIEW
CREOH* 42,25,2002
TOXICOLOGY REVIEW
MUREAV 562,77,2004


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Supported RBREV* -,129,1998
Mine Safety and Health Administration (MSHA) STANDARD - air ceiling concentration 5 mg(Mn)/m3 DTLVS* 3,149,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) ceiling concentration 5 mg(Mn)/m3 CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) ceiling concentration 5 mg(Mn)/m3 CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) ceiling concentration 5 mg(Mn)/m3 CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) ceiling concentration 5 mg(Mn)/m3 CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 5 mg(Mn)/m3, JAN1993
Occupational Exposure Limit - BELGIUM time-weighted average 5 mg(Mn)/m3, JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 2.5 mg(Mn)/m3, JAN1999
Occupational Exposure Limit - FINLAND time-weighted average 2.5 mg(Mn)/m3, JAN1999
Occupational Exposure Limit - GERMANY MAK 0.5 mg(Mn)/m3, JAN1999
Occupational Exposure Limit - HUNGARY time-weighted average 0.3 mg(Mn)/m3, short term exposure limit 0.6 mg(Mn)/m3, JAN1993
Occupational Exposure Limit - POLAND MAC(time-weighted average) 0.3 mg(Mn)/m3, JAN1993
Occupational Exposure Limit - RUSSIA short term exposure limit 0.5 mg/m3, JAN1993
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 5 mg(Mn)/m3, SEP2000
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: A1785;
Number of Industries 1;
Total Number of Facilities 297;
Number of Occupations 1;
Total Number of Employees Exposed 593


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Positive: S cerevisiae-homozygosis
EPA GENETOX PROGRAM 1988, Weakly Positive: In vitro UDS-human fibroblast
EPA GENETOX PROGRAM 1988, Negative: S cerevisiae gene conversion
Used as a broad spectrum contact fungicide
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
OSHA ANALYTICAL METHOD #107


REFERENCES:

CODEN
REFERENCE
85JFAN "Agrochemicals Handbook," with updates, Hartley, D., and H. Kidd, eds., Nottingham, Royal Soc. of Chemistry, 1983-86
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974-
ATSUDG Archives of Toxicology, Supplement. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) No.1- 1978-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
CREOH* Critical Reviews in Oncology/Hematology (Elsevier Science, P.O.Box 7247-7682,Philadelphia,PA 19170 -7682,USA OR Elsevier Science B.V.,P.O.Box 1270,1000 BG Amsterdam,The Netherlands) V. 1- 1983-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
EQSSDX Environmental Quality and Safety, Supplement. (Stuttgart, Fed. Rep. Ger.) V.1-5, 1975-76. Discontinued.
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
FMCHA2 Farm Chemicals Handbook. (Meister Pub., 37841 Euclid Ave., Willoughy, OH 44094)
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
GMCRDC Gann Monograph on Cancer Research. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No. 11- 1971-
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979-
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76-
MMAPAP Mycopathologia et Mycologia Applicata. (The Hague, Netherlands) V.5-54(4), 1950-74. For publisher information, see MYCPAH.
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NRTXDN Neurotoxicology. (Intox Press, Inc., POB 34075, Little Rock, AR 72203) V.1- 1979-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
PCOC** Pesticide Chemicals Official Compendium, Association of the American Pesticide Control Officials, Inc., 1966. (Topeka, KS)
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
REPTED Reproductive Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987-
RSTUDV Rivista di Scienza e Technologia degli Alimenti e di Nutrizione Umana. Review of Science and Technology of Food and Human Nutrition. (Bologna, Italy) V.5-6, 1975-76. Discontinued.
TCMUD8 Teratogenesis, Carcinogenesis, and Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1980-
TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968-
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
VPITAR Voprosy Pitaniya. Problems of Nutrition. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-10, 1932-41; V.11- 1952-

Used as a broad spectrum contact fungicide

NIOSH PROFILE (MANGANESE AND ITS COMPOUNDS), SRC, 4/82

RTECS Compound Description:
   Agricultural Chemical
   Tumorigen
   Mutagen
   Reproductive Effector

ALT CAS #: 301-03-1
ALT CAS #: 11004-49-2
ALT CAS #: 12125-33-6
ALT CAS #: 20316-06-7
ALT CAS #: 28355-56-8
ALT CAS #: 133317-06-3
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