The Registry of Toxic Effects of Chemical Substances

Manganese, tricarbonyl methylcyclopentadienyl

RTECS #: OP1450000

CAS #: 12108-13-3

UPDATE: November 2004 MW: 218.10 MF: C9H7MnO3


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. 2 - Methylcyclopentadienyl manganese tricarbonyl
  2. 2 - Methylcyclopentadienyl manganese tricarbonyl (ACGIH)
  3. AK - 33X
  4. Antiknock - 33
  5. CI - 2
  6. Combustion improver - 2
  1. MMT
  2. Manganese, (methylcyclopentadienyl) tricarbonyl -
  3. Methylcyclopentadienyl manganese tricarbonyl
  4. Methylcyklopentadientrikarbonylmanganium (Czech)
  5. Tricarbonyl (methylcyclopentadienyl) manganese


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
skin
rabbit 		100 mg/24 hour mild AEHLAU 30,168,1975


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
cat 		lowest published lethal concentration: 223 mg/m3/7 hour N/R TMMT** -,-,1976
inhalation
dog 		lowest published lethal concentration: 489 mg/m3/2 hour N/R TMMT** -,-,1976
inhalation
guinea pig 		lowest published lethal concentration: 411 mg/m3/7 hour N/R TMMT** -,-,1976
inhalation
mouse 		lethal concentration (50 percent kill): 58,600 µg/m3/4 hour N/R SAIGBL 20,553,1978
inhalation
rat 		lethal concentration (50 percent kill): 76 mg/m3/4 hour Eye: Conjunctiva irritation

Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Dyspnea 		AIHAAP 40,164,1979
inhalation
rabbit 		lowest published lethal concentration: 411 mg/m3/7 hour N/R TMMT** -,-,1976
intraperitoneal
mouse 		lethal dose (50 percent kill): 152 mg/kg Behavioral: Convulsions or effect on seizure threshold

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		SKIZAB 34,183,1978
intraperitoneal
rat 		lethal dose (50 percent kill): 12 mg/kg Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Chronic pulmonary edema or congestion

Blood: Hemorrhage 		TOLED5 39,1,1987
intravenous
dog 		lowest published lethal dose: 10 mg/kg N/R TMMT** -,-,1976
intravenous
rabbit 		lethal dose (50 percent kill): 6,600 µg/kg N/R TMMT** -,-,1976
oral
dog 		lowest published lethal dose: 620 mg/kg N/R TMMT** -,-,1976
oral
guinea pig 		lethal dose (50 percent kill): 905 mg/kg N/R TMMT** -,-,1976
oral
mouse 		lethal dose (50 percent kill): 34 mg/kg N/R NICHAS 44,173,1985
oral
rat 		lethal dose (50 percent kill): 8 mg/kg N/R TMMT** -,-,1976
oral
rabbit 		lethal dose (50 percent kill): 95 mg/kg N/R TMMT** -,-,1976
skin
rat 		lethal dose (50 percent kill): 665 mg/kg N/R TMMT** -,-,1976
skin
rabbit 		lethal dose (50 percent kill): 140 mg/kg Behavioral: Convulsions or effect on seizure threshold

Behavioral: Excitement

Lung, Thorax, or Respiration: Cyanosis 		AIHAAP 40,164,1979


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lowest published toxic dose: 75,426 mg/kg/1 year- intermittent Kidney, Ureter, and Bladder: Other changes in urine composition

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		AECTCV 23,473,1992


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.2 mg(Mn)/m3 (skin) DTLVS* TLV/BEI,2003
TOXICOLOGY REVIEW
AMRL** TR-73-125,1973
TOXICOLOGY REVIEW
85DHAX Mn,126,1973


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 0.1 ppm (0.2 mg/m3) (skin) DTLVS* 3,164,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) ceiling concentration 5 mg(Mn)/m3 CFRGBR 29,1915.1000,1993
Occupational Exposure Limit - AUSTRALIA time-weighted average 0.2 mg/m3, Skin, JAN1993
Occupational Exposure Limit - BELGIUM time-weighted average 0.2 mg/m3, Skin, JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 0.1 ppm (0.2 mg(Mn)/m3), Skin, JAN1999
Occupational Exposure Limit - FINLAND time-weighted average 0.2 mg/m3, short term exposure limit 0.6 mg/m3, Skin, JAN1993
Occupational Exposure Limit - FRANCE VME 0.2 mg/m3, Skin, JAN1999
Occupational Exposure Limit - SWITZERLAND MAK- week 0.1 ppm (0.2 mg(Mn)/m3), JAN1999
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 0.2 mg(Mn).m3, short term exposure limit 0.6 mg(Mn)/m3, Skin, SEP2000
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 0.2 mg/m3, Skin, 2003
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 0.2 mg(Mn)/m3 (skin)
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 0.2 mg(Mn)/m3 (skin)


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO THE CHEMICAL-air 10 hour time-weighted average 0.2 mg/m3 (Sk) NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 84547;
Number of Industries 1;
Total Number of Facilities 11;
Number of Occupations 1;
Total Number of Employees Exposed 34
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 84547;
Number of Industries 2;
Total Number of Facilities 65;
Number of Occupations 5;
Total Number of Employees Exposed 4,891


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as an octane improver in unleaded gasoline
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
85DHAX "Medical and Biologic Effects of Environmental Pollutants Series," Washington, DC, National Academy of Sciences, 1972-77
AECTCV Archives of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 070944) V.1- 1973-
AEHLAU Archives of Environmental Health. (Heldref Pub., 4000 Albemarle St., NW, Washington, DC 20016) V.1- 1960-
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958-
AMRL** Aerospace Medical Research Laboratory Report. (Aerospace Technical Div., Air Force Systems Command, Wright-Patterson Air Force Base, OH 45433)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
NICHAS Nichidai Igaku Zasshi. Nihon University Medical Journal. (Nihon Daigaku Igakkai, 30, Oyaguchi kami-machi, Itabashi-ku, Tokyo 173, Japan) V.1- 1937-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
SAIGBL Sangyo Igaku. Japanese Journal of Industrial Health. (Nippon Sangyo Eisei Igakkai, Kosu Eisei Bldg., 1-29-8, Shinjuku, Shinjuku-ku, Tokyo 160, Japan) V.1- 1959-
SKIZAB Shikoku Igaku Zasshi. Shikoku Medical Journal. (Tokushima Igakkai, Tokushima Daigaku Igakubu, Kuramoto-cho, Tokushima 770, Japan) V.1- 1950-
TMMT** "The Toxicology of Methylcyclopentadienyl Manganese Tricarbonyl," Witherup, S., et al., Cincinnati, OH, Univ. of Cincinnati, 1976
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-

Used as an octane improver in unleaded gasoline

RTECS Compound Description:
   Organometallic
   Primary Irritant

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