The Registry of Toxic Effects of Chemical Substances

Malononitrile

RTECS #: OO3150000

CAS #: 109-77-3

UPDATE: December 2000 MW: 66.07 MF: C3H2N2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. NIOSH DOCUMENTATION AND SURVEILLANCE:
  6. STATUS IN FEDERAL AGENCIES:
  7. REFERENCES:

SYNONYMS:

  1. Cyanoacetonitrile
  2. Dicyanomethane
  3. Dwumetylosulfotlenku (Polish)
  4. Malonic dinitrile
  5. Methane, dicyano -
  6. Methylene cyanide
  1. Nitril kyseliny malonove (Czech)
  2. RCRA waste number U149
  3. Malonic acid dinitrile
  4. Propanedinitrite
  5. USAF KF - 19
  6. USAF A - 4600


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		5 mg/24 hour severe 85JCAE -,899,1986


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lethal dose (50 percent kill): 13 mg/kg Behavioral: General anesthetic

Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Dyspnea 		NATUAS 228,1315,1970
intraperitoneal
rat 		lethal dose (50 percent kill): 20,550 µg/kg Behavioral: Convulsions or effect on seizure threshold

Behavioral: Excitement 		MEPAAX 27,1,1976
intraperitoneal
rabbit 		lethal dose (50 percent kill): 10,043 µg/kg Blood: Other changes TOXID9 3,64,1983
intravenous
mouse 		lethal dose (50 percent kill): 32 mg/kg N/R CSLNX* NX#07576
intravenous
rabbit 		lethal dose (50 percent kill): 28 mg/kg N/R PJPPAA 31,563,1979
oral
mouse 		lethal dose (50 percent kill): 19 mg/kg N/R KHZDAN 9,50,1966
oral
rat 		lethal dose (50 percent kill): 14 mg/kg N/R NTIS** OTS0526327
subcutaneous
dog 		lowest published lethal dose: 6,500 µg/kg Behavioral: Convulsions or effect on seizure threshold

Gastrointestinal: Nausea or vomiting 		AIPTAK 3,77,1897
subcutaneous
frog 		lowest published lethal dose: 95 mg/kg N/R AIPTAK 3,77,1897
subcutaneous
guinea pig 		lethal dose (50 percent kill): 21 mg/kg Behavioral: Convulsions or effect on seizure threshold

Behavioral: Excitement 		MEPAAX 27,1,1976
subcutaneous
mouse 		lowest published lethal dose: 8 mg/kg N/R AIPTAK 3,77,1897
subcutaneous
pigeon 		lowest published lethal dose: 80 mg/kg N/R AIPTAK 3,77,1897
subcutaneous
rat 		lethal dose (50 percent kill): 31,500 µg/kg Behavioral: Convulsions or effect on seizure threshold

Behavioral: Excitement 		MEPAAX 27,1,1976
subcutaneous
rabbit 		lowest published lethal dose: 6 mg/kg N/R CRSBAW 96,202,1927
skin
rat 		lethal dose (50 percent kill): 350 mg/kg Behavioral: Convulsions or effect on seizure threshold

Behavioral: Excitement 		MEPAAX 27,1,1976


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 28,500 mg/kg/19 week- intermittent Liver: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		KHZDAN 15,553,1972
oral
rat 		lowest published toxic dose: 164 mg/kg/28 day- intermittent Liver: Other changes

Kidney, Ureter, and Bladder: Other changes 		NTIS** OTS0526327


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO MALONONITRILE-air 10 hour time-weighted average 3 ppm NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X5636;
Number of Industries 1;
Total Number of Facilities 4;
Number of Occupations 15;
Total Number of Employees Exposed 1,233


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used in organic synthesis
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898-
CRSBAW Comptes Rendus des Seances de la Societe de Biologie et de Ses Filiales. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1849-
CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010)
KHZDAN Khigiena i Zdraveopazvane. Hygiene and Sanitation. (Hemus, Blvd. Russki 6, Sofia, Bulgaria) V.9- 1966-
MEPAAX Medycyna Pracy. Industrial Medicine. (Ars-Polona, POB 1001, 00-068 Warsaw 1, Poland) V.1- 1950-
NATUAS Nature. (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736) V.1- 1869-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
PJPPAA Polish Journal of Pharmacology and Pharmacy. (ARS Polona, POB 1001, 00-068 Warsaw 1, Poland) V.25-44, 1973-92. For publisher information, see PJPAE3
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-

Used in organic synthesis

NIOSH PROFILE (NITRILES), SRC, 10/77

RTECS Compound Description:
   Primary Irritant

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