The Registry of Toxic Effects of Chemical Substances

Malonic acid

RTECS #: OO0175000

CAS #: 141-82-2

UPDATE: August 2003 MW: 104.07 MF: C3H4O4


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. ACUTE TOXICITY DATA:
  5. NIOSH DOCUMENTATION AND SURVEILLANCE:
  6. STATUS IN FEDERAL AGENCIES:
  7. REFERENCES:

SYNONYMS:

  1. Dicarboxymethane
  2. Carboxyacetic acid
  3. Kyselina malonova (Czech)
  1. Methanedicarboxylic acid
  2. Propanedioic acid
  3. USAF EK - 695


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		100 mg severe BIOFX* 22-3/1971
skin
rabbit 		500 mg/24 hour mild BIOFX* 22-3/1971


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
morphological transform oral
rat 		10,080 mg/kg/6 week CRNGDP 9,387,1988


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lethal concentration (50 percent kill): >8,900 mg/m3/1 hour N/R BIOFX* 22-3/1971
intraperitoneal
mouse 		lethal dose (50 percent kill): 300 mg/kg N/R NTIS** AD277-689
intraperitoneal
rat 		lethal dose (50 percent kill): 1,500 mg/kg N/R 38MKAJ 2C,4937,1982
intraperitoneal
rat 		lowest published toxic dose: 500 mg/kg Endocrine: Aldosteronism

Endocrine: Other changes 		EKFAE9 55,56,1992
oral
mouse 		lethal dose (50 percent kill): 4 gm/kg Tumorigenic: Active as anti-cancer agent BIJOAK 34,1196,1940
oral
rat 		lethal dose (50 percent kill): 1,310 mg/kg Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Dyspnea

Lung, Thorax, or Respiration: Cyanosis 		BIOFX* 22-3/1971
skin
rabbit 		lowest published lethal dose: 10 gm/kg N/R BIOFX* 22-3/1971


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X4746;
Number of Industries 2;
Total Number of Facilities 46;
Number of Occupations 3;
Total Number of Employees Exposed 1,913;
Total Number of Female Employees Exposed 272


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY


REFERENCES:

CODEN
REFERENCE
38MKAJ "Patty's Industrial Hygiene and Toxicology," 3rd rev. ed., Clayton, G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82. Vol. 3 originally pub. in 1979; pub. as 2nd rev. ed. in 1985.
BIJOAK Biochemical Journal. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1906-
BIOFX* BIOFAX Industrial Bio-Test Laboratories, Inc., Data Sheets. (1810 Frontage Rd., Northbrook, IL 60062)
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980-
EKFAE9 Eksperimental'naya i Klinicheskaya Farmakologiya. Experimental and Clinical Pharmacology. (Mezhdunarodnaya Kniga, ul. B. Yakimanka, 39, 117049 Moscow, Russia) V.55- 1992-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.

RTECS Compound Description:
   Mutagen
   Natural Product
   Primary Irritant

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