The Registry of Toxic Effects of Chemical Substances

Maleic acid

RTECS #: OM9625000

CAS #: 110-16-7

UPDATE: October 1997 MW: 116.08 MF: C4H4O4


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. ACUTE TOXICITY DATA:
  5. NIOSH DOCUMENTATION AND SURVEILLANCE:
  6. STATUS IN FEDERAL AGENCIES:
  7. REFERENCES:

SYNONYMS:

  1. cis - 1,2 - Ethylenedicarboxylic acid
  2. 1,2 - Ethylenedicarboxylic acid, (Z)
  3. Butenedioic acid, (Z) -
  4. cis - Butenedioic acid
  1. Kyselina maleinova (Czech)
  2. Toxilic acid
  3. Maleinic acid
  4. Malenic acid


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		100 mg severe BIOFX* 7-4/1970
eye
rabbit 		1%/2 minute severe AJOPAA 33,387,1950
skin
rabbit 		500 mg/24 hour mild BIOFX* 7-4/1970


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
DNA inhibition human fibroblast 20 mmol/L MUREAV 183,89,1987


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lethal concentration (50 percent kill): >720 mg/m3/1 hour N/R BIOFX* 7-4/1970
oral
mouse 		lethal dose (50 percent kill): 2,400 mg/kg Tumorigenic: Active as anti-cancer agent BIJOAK 34,1196,1940
oral
rat 		lethal dose (50 percent kill): 708 mg/kg Behavioral: Convulsions or effect on seizure threshold

Behavioral: Muscle weakness

Gastrointestinal: Ulceration or bleeding from stomach 		BIOFX* 7-4/1970
skin
rabbit 		lethal dose (50 percent kill): 1,560 mg/kg Behavioral: Tremor BIOFX* 7-4/1970


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 84505;
Number of Industries 22;
Total Number of Facilities 1,840;
Number of Occupations 27;
Total Number of Employees Exposed 17,036
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 84505;
Number of Industries 36;
Total Number of Facilities 2,076;
Number of Occupations 45;
Total Number of Employees Exposed 30,064;
Total Number of Female Employees Exposed 11,590


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used in manufacture of resins and drugs, also used to retard rancidity of fats and oils
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
AJOPAA American Journal of Ophthalmology. (Ophthalmic Pub. Co., 435 N. Michigan Ave., Suite 1415, Chicago, IL 60611) Series 3: V.1- 1918-
BIJOAK Biochemical Journal. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1906-
BIOFX* BIOFAX Industrial Bio-Test Laboratories, Inc., Data Sheets. (1810 Frontage Rd., Northbrook, IL 60062)
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-

Used in manufacture of resins and drugs, also used to retard rancidity of fats and oils

NIOSH PROFILE (ACIDS, ORGANIC), SRI, 2/77

NIOSH PROFILE (ACIDS, ORGANIC), SRC, 4/78

RTECS Compound Description:
   Mutagen
   Primary Irritant

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