The Registry of Toxic Effects of Chemical Substances

Magnesium oxide

RTECS #: OM3850000

CAS #: 1309-48-4

UPDATE: November 2004 MW: 40.31 MF: MgO


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. TUMORIGENIC DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. Akro - mag
  2. Animag
  3. Calcined brucite
  4. Calcined magnesia
  5. Calcined magnesite
  6. Granmag
  7. Magcal
  8. Magchem 100
  9. Maglite
  10. Magnesia
  11. Magnesia USTA
  12. Magnesium oxide fume
  1. Magnesium oxide fume (ACGIH:OSHA)
  2. Magnezu tlenek (Polish)
  3. Magox
  4. Magox 85
  5. Magox 90
  6. Magox 95
  7. Magox 98
  8. Magox OP
  9. Marmag
  10. Oxymag
  11. Periclase
  12. Seawater magnesia


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intratracheal
hamster 		lowest published toxic dose: 480 mg/kg/30 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Olfaction: Tumors

Lung, Thorax, or Respiration: Tumors 		CNREA8 33,2209,1973


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
human 		lowest published toxic concentration: 400 mg/m3 N/R 38MKAJ 2A,1745,1981
inhalation
mammal (species unspecified) 		lowest published toxic concentration: 4 mg/m3/12 minute Nutritional and Gross Metabolic: Body temperature increase VCVN1* -,104,1988


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published toxic concentration: 1,120 µg/m3/24 hour/29 day- continuous Brain and Coverings: Recordings from specific areas of CNS

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		GISAAA 49(11),82,1984
inhalation
rat 		lowest published toxic concentration: 1,000 mg/m3/4 hour/50 day- intermittent Lung, Thorax, or Respiration: Other changes

Blood: Other hemolysis with or without anemia 		VCVN1* -,105,1988


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 10 mg/m3 ( intermittent) DTLVS* TLV/BEI,2003
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Not Classifiable as a Human Carcinogen DTLVS* TLV/BEI,2003


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 10 mg/m3 (fume) DTLVS* 3,147,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 15 mg/m3, total particulate CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 15 ppm, total particulate CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 15 ppm, total particulate CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 15 mg/m3 CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - ARAB Republic of Egypt time-weighted average 10 mg/m3, JAN1993
Occupational Exposure Limit - AUSTRALIA time-weighted average 10 mg/m3, JAN1993
Occupational Exposure Limit - AUSTRIA MAK 6 mg/m3, JAN1999
Occupational Exposure Limit - BELGIUM time-weighted average 10 mg/m3, JAN1993
Occupational Exposure Limit - FRANCE VME 10 mg/m3, JAN1999
Occupational Exposure Limit - GERMANY MAK 6 mg/m3, JAN1999
Occupational Exposure Limit - HUNGARY time-weighted average 5 mg/m3, short term exposure limit 10 mg/m3, JAN1993
Occupational Exposure Limit - NORWAY time-weighted average 10 mg/m3, JAN1999
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 10 mg/m3, 2003
Occupational Exposure Limit - POLAND MAC(time-weighted average) fume 5 mg/m3, JAN1999
Occupational Exposure Limit - POLAND MAC(time-weighted average) dust 10 mg/m3, JAN1999
Occupational Exposure Limit - RUSSIA short term exposure limit 5 mg/m3, JAN1993
Occupational Exposure Limit - SWITZERLAND MAK- week 6 mg/m3, JAN1999
Occupational Exposure Limit - TURKEY time-weighted average 15 mg/m3, JAN1993
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 10 mg(Mg)/m3, total inhalable dust, SEP2000
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 4 mg(Mg)/m3, fume and respirable dust, SEP2000
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Not Classifiable as a Human Carcinogen
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Not Classifiable as a Human Carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 80298;
Number of Industries 201;
Total Number of Facilities 28,931;
Number of Occupations 134;
Total Number of Employees Exposed 354,380
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 80298;
Number of Industries 258;
Total Number of Facilities 42,587;
Number of Occupations 177;
Total Number of Employees Exposed 765,812;
Total Number of Female Employees Exposed 149,523


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Elements by ICP, 7300
OSHA ANALYTICAL METHOD #ID-125G


REFERENCES:

CODEN
REFERENCE
38MKAJ "Patty's Industrial Hygiene and Toxicology," 3rd rev. ed., Clayton, G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82. Vol. 3 originally pub. in 1979; pub. as 2nd rev. ed. in 1985.
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
VCVN1* "Vrednie chemichescie veshestva. Neorganicheskie soedinenia elementov I-IV groopp" (Hazardous substances. Inornanic substances containing I-IV group elements), Filov V.A., Chimia, 1988.

NIOSH PROFILE (PETROLEUM REFINING), FIRL, 4/78

NIOSH PROFILE (PULP AND PAPER MILLS), SRI, 2/77

NIOSH PROFILE (TIRE MANUFACTURING), SRI, 2/77

NIOSH PROFILE (TIRE MANUFACTURING), FIRL, 4/78

FDA-over the counter drug

RTECS Compound Description:
   Tumorigen
   Human Data

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