The Registry of Toxic Effects of Chemical Substances

Lithium hydride

RTECS #: OJ6300000

CAS #: 7580-67-8

UPDATE: November 2004 MW: 7.95 MF: HLi


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. ACUTE TOXICITY DATA:
  3. OTHER MULTIPLE DOSE DATA:
  4. REVIEWS:
  5. STANDARDS AND REGULATIONS:
  6. NIOSH DOCUMENTATION AND SURVEILLANCE:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. Hydrure de lithium (French)
  1. Lithium hydride (ACGIH:OSHA)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
dog 		lowest published lethal concentration: 110 mg/m3/1 hour Olfaction: Other olfaction effects

Behavioral: Convulsions or effect on seizure threshold

Cardiac: EKG changes not diagnostic of above 		STGNBT -,150,1999
inhalation
human 		lowest published toxic dose: 200 µg/m3 Olfaction: Other olfaction effects

Eye: Other eye effects

Blood: Other changes 		STGNBT -,150,1999
inhalation
human 		lowest published toxic concentration: 0.2 mg/m3 N/R VCVN1* -,28,1998
inhalation
human 		lowest published toxic concentration: 0.2 mg/m3 Olfaction: Deviated nasal septum

Eye: Lacrimation

Skin: After topical application: Primary irritation 		VCVN1* -,28,1998
inhalation
rat 		lowest published lethal concentration: 10 mg/m3/4 hour Lung, Thorax, or Respiration: Cough AMIHAB 14,468,1956
inhalation
rabbit 		lowest published lethal concentration: 110 mg/m3/1 hour Olfaction: Other olfaction effects

Behavioral: Convulsions or effect on seizure threshold

Cardiac: EKG changes not diagnostic of above 		STGNBT -,150,1999
intravenous
rabbit 		lethal dose (50 percent kill): 20 mg/kg N/R STGNBT -,150,1999
oral
rat 		lethal dose (50 percent kill): 77,500 µg/kg N/R STGNBT -,150,1999
subcutaneous
rat 		lethal dose (50 percent kill): 50 mg/kg N/R STGNBT -,150,1999
subcutaneous
rabbit 		lethal dose (50 percent kill): 44,600 µg/kg N/R STGNBT -,150,1999
skin
human 		lowest published toxic concentration: 0.1 pph N/R VCVN1* -,29,1998
skin
human 		lowest published toxic concentration: 0.1 pph Skin: After topical application: Primary irritation VCVN1* -,29,1998


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
guinea pig 		lowest published toxic concentration: 5 mg/m3/4 hour- intermittent Olfaction: Other olfaction effects

Eye: Other eye effects

Skin: After systemic exposure: Dermatitis, other 		AMIHAB 14,468,1956
inhalation
mammal (species unspecified) 		lowest published toxic concentration: 2 mg/m3/30 minute/26 week- intermittent Cardiac: EKG changes not diagnostic of above

Liver: Liver function tests impaired

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		STGNBT -,150,1999
inhalation
mouse 		lowest published toxic concentration: 5 mg/m3/4 hour/1 week- intermittent Olfaction: Other olfaction effects

Skin: After systemic exposure: Dermatitis, other 		AMIHAB 14,468,1956
inhalation
rat 		lowest published toxic concentration: 5 mg/m3/4 hour/1 week- intermittent Olfaction: Other olfaction effects

Skin: After systemic exposure: Dermatitis, other 		AMIHAB 14,468,1956
inhalation
rabbit 		lowest published toxic concentration: 5 mg/m3/4 hour/1 week- intermittent Olfaction: Other olfaction effects

Eye: Other eye effects

Skin: After systemic exposure: Dermatitis, other 		AMIHAB 14,468,1956


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.025 mg/m3 DTLVS* TLV/BEI,2003


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 0.025 mg/m3 DTLVS* 3,147,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 0.025 mg/m3 CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 0.025 mg/m3 CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 0.025 mg/m3 CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 0.025 mg/m3 CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 0.025 mg/m3, JAN1993
Occupational Exposure Limit - AUSTRIA MAK 0.025 mg/m3, JAN1999
Occupational Exposure Limit - BELGIUM time-weighted average 0.025 mg/m3, JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 0.025 mg/m3, JAN1999
Occupational Exposure Limit - FINLAND time-weighted average 0.025 mg/m3, short term exposure limit 0.075 mg/m3, JAN1999
Occupational Exposure Limit - FRANCE VME 0.025 mg/m3, JAN1999
Occupational Exposure Limit - GERMANY No MAK Established, JAN1999
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 0.025 mg/m3, 2003
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 0.025 mg/m3, JAN1993
Occupational Exposure Limit - POLAND MAC(time-weighted average) 0.025 mg/m3, JAN1999
Occupational Exposure Limit - SWITZERLAND MAK- week 0.025 mg/m3, JAN1999
Occupational Exposure Limit - TURKEY time-weighted average 0.025 mg/m3, JAN1993
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 0.025 mg/m3, SEP2000
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 0.025 mg/m3
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 0.025 mg/m3


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO LITHIUM HYDRIDE-air 10 hour time-weighted average 0.025 mg/m3 NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 43115;
Number of Industries 1;
Total Number of Facilities 11;
Number of Occupations 1;
Total Number of Employees Exposed 11


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY


REFERENCES:

CODEN
REFERENCE
AMIHAB AMA Archives of Industrial Health. (Chicago, IL) V.11-21, 1955-60. For publisher information, see AEHLAU.
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
STGNBT "Spravochnik po Toksikologii i Gigienicheskim Normativam (PDK) Potentsial'no Opasnykh Khimicheskikh Veshchestv" Kushneva, V.S., and R.B. Gorshkova, eds. 46, Zhivopisnaya St., 123182, Moscow, Russia, IzdAT 1999
VCVN1* "Vrednie chemichescie veshestva. Neorganicheskie soedinenia elementov I-IV groopp" (Hazardous substances. Inornanic substances containing I-IV group elements), Filov V.A., Chimia, 1988.

Used in preparation of LITHIUM ALUMINUM HYDRIDE

NIOSH PROFILE (LITHIUM AND ITS COMPOUNDS), SRC, 4/78

RTECS Compound Description:
   Human Data

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