The Registry of Toxic Effects of Chemical Substances

Lithium carbonate (2:1)

[Oxytropis sericea]

RTECS #: OJ5800000

CAS #: 554-13-2

UPDATE: May 2005 MW: 73.89 MF: CO3•2Li


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. TUMORIGENIC DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. REVIEWS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. CP - 15467 - 61
  2. Camcolit
  3. Candamide
  4. Carbolith
  5. Carbolithium
  6. Carbonic acid lithium salt
  7. Carbonic acid, dilithium salt
  8. Ceglution
  9. Dilithium carbonate
  10. Eskalith
  11. Hypnorex
  12. Limas
  13. Liskonum
  1. Lithane
  2. Lithicarb
  3. Lithinate
  4. Lithium carbonate
  5. Lithobid
  6. Lithonate
  7. Lithotabs
  8. NSC - 16895
  9. Plenur
  10. Priadel
  11. Quilonum retard
  12. Teralithe (French)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis unreported route
human 		12,800 µg/kg/12 week- intermittent TJADAB 13,131,1976
cytogenetic analysis oral
mouse 		1,200 µg/kg/3 day- intermittent CYTOAN 54,245,1989
DNA damage human fibroblast 500 mg/L MUREAV 169,171,1986
DNA inhibition human fibroblast 2 gm/L MUREAV 169,171,1986
DNA inhibition oral
rat 		420 gm/kg/12 week- continuous MUREAV 244,331,1990
mutation in mammalian somatic cells hamster lung 2 gm/L MUREAV 169,171,1986
sister chromatid exchange oral
mouse 		1,200 µg/kg/3 day- intermittent CYTOAN 54,245,1989


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lowest published toxic dose: 42 mg/kg (60 day male) Reproductive: Effects on fertility: Male fertility index (e.g., # males impregnating females per # males exposed to fertile nonpregnant females) 56ZJAL 4,423,1996
intraperitoneal
mouse 		lowest published toxic dose: 40 mg/kg (8 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) NNAPBA 270,56,1971
intraperitoneal
mouse 		lowest published toxic dose: 200 mg/kg (8 day pregnant) Reproductive: Specific developmental abnormalities: Central nervous system TJADAB 26,239,1982
intraperitoneal
mouse 		lowest published toxic dose: 200 mg/kg (9 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system TJADAB 26,239,1982
intraperitoneal
mouse 		lowest published toxic dose: 300 mg/kg (8 day pregnant) Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue) 		ARTODN 71,519,1997
oral
mouse 		lowest published toxic dose: 4,650 mg/kg (6-15 day pregnant) Reproductive: Effects on embryo or fetus: Fetal death

Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue) 		NATUAS 225,73,1970
oral
mouse 		lowest published toxic dose: 4,650 mg/kg (6-15 day pregnant) Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)

Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth) 		TXAPA9 17,274,1970
oral
mouse 		lowest published toxic dose: 2 gm/kg (8-12 day pregnant) Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth) JTEHD6 10,541,1982
oral
mouse 		lowest published toxic dose: 600 mg/kg (7-12 day pregnant) Reproductive: Effects on embryo or fetus: Fetal death

Reproductive: Effects on newborn: Sex ratio 		KSRNAM 7,1736,1973
oral
pig 		lowest published toxic dose: 240 gm/kg (36-115 day pregnant) Reproductive: Effects on newborn: Stillbirth

Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)

Reproductive: Effects on newborn: Weaning or lactation index (e.g., # alive at weaning per # alive at day 4) 		PSEBAA 158,123,1978
oral
pig 		lowest published toxic dose: 240 gm/kg (36-115 day pregnant) Reproductive: Effects on newborn: Other neonatal measures or effects PSEBAA 158,123,1978
oral
rat 		lowest published toxic dose: 600 mg/kg (9-14 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system KSRNAM 7,1736,1973
oral
rat 		lowest published toxic dose: 1 gm/kg (6-15 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system 		TOLED5 34,115,1986
oral
rat 		lowest published toxic dose: 1,050 mg/kg (1-21 day pregnant) Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) 		NTRSDC 10,315,1990
oral
rat 		lowest published toxic dose: 1,050 mg/kg (21 day after birth) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) NTRSDC 10,315,1990
oral
rat 		lowest published toxic dose: 1.52 gm/kg (1-19 day pregnant) Reproductive: Other developmental abnormalities FATOAO 48,73,1985
oral
rat 		lowest published toxic dose: 800 mg/kg (15-19 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) FATOAO 46,108,1983
oral
rat 		lowest published toxic dose: 1,120 mg/kg (1-7 day pregnant) Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)

Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) 		FATOAO 46,108,1983
oral
rat 		lowest published toxic dose: 1,120 mg/kg (8-14 day pregnant) Reproductive: Effects on embryo or fetus: Fetal death FATOAO 46,108,1983
oral
rat 		lowest published toxic dose: 1,520 mg/kg (1-19 day pregnant) Reproductive: Effects on newborn: Behavioral FATOAO 48,73,1985
oral
rat 		lowest published toxic dose: 33 gm/kg (30 day male) Reproductive: Effects on fertility: Male fertility index (e.g., # males impregnating females per # males exposed to fertile nonpregnant females) REPTED 17,683,2003
oral
woman 		lowest published toxic dose: 3,072 mg/kg (1-37 week pregnant) Reproductive: Effects on newborn: Other neonatal measures or effects JOPDAB 81,804,1972
oral
woman 		lowest published toxic dose: 4,900 mg/kg (1-35 week pregnant) Reproductive: Specific developmental abnormalities: Cardiovascular (circulatory) system LANCAO 2,595,1974
oral
woman 		lowest published toxic dose: 4,256 mg/kg (1-38 week pregnant) Reproductive: Effects on newborn: Apgar score (human only)

Reproductive: Effects on newborn: Other neonatal measures or effects 		BMJOAE 3,233,1973
oral
woman 		lowest published toxic dose: 10,080 mg/kg (26 week prior to copulation-34 week pregnant) Reproductive: Effects on newborn: Stillbirth BJPYAJ 154,114,1989
unreported route
mouse 		lowest published toxic dose: 4,650 mg/kg (6-15 day pregnant) Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue) LANCAO 2,849,1969
unreported route
woman 		lowest published toxic dose: 540 mg/kg (35-39 week pregnant) Reproductive: Effects on newborn: Other neonatal measures or effects PEDIAU 47,94,1971
unreported route
woman 		lowest published toxic dose: 556 mg/kg (30-34 week pregnant) Reproductive: Effects on newborn: Other neonatal measures or effects JAMAAP 213,865,1970
unreported route
woman 		lowest published toxic dose: 11,520 mg/kg (7 week prior to copulation/1-38 week pregnant) Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Specific developmental abnormalities: Musculoskeletal system

Reproductive: Specific developmental abnormalities: Gastrointestinal system 		CMAJAX 105,847,1971
unreported route
woman 		lowest published toxic dose: 11,520 mg/kg (7 week prior to copulation/1-38 week pregnant) Reproductive: Effects on newborn: Apgar score (human only)

Reproductive: Effects on newborn: Other neonatal measures or effects 		CMAJAX 105,847,1971


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
man 		toxic dose : 6,132 mg/kg/2 year- continuous Tumorigenic: Carcinogenic by RTECS criteria

Blood: Leukemia 		HAEMAX 67,944,1982
oral
rat 		lowest published toxic dose: 5,687.5 mg/kg/91 day- continuous Tumorigenic: Carcinogenic by RTECS criteria

Kidney, Ureter, and Bladder: Bladder tumors

Tumorigenic: Facilitates action of known carcinogens 		VOONC* -,1309,1992
oral
woman 		lowest published toxic dose: 3,600 mg/kg/21 week- continuous Tumorigenic: Carcinogenic by RTECS criteria

Blood: Leukemia 		NEJMAG 302,808,1980
oral
woman 		toxic dose : 21 gm/kg/3.5 year- continuous Tumorigenic: Carcinogenic by RTECS criteria

Endocrine: Thyroid tumors 		ANZJB8 10,62,1980
oral
woman 		toxic dose : 5,940 mg/kg/47 week- continuous Tumorigenic: Carcinogenic by RTECS criteria

Blood: Leukemia 		AIMEAS 92,262,1980


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lethal dose (50 percent kill): 236 mg/kg Behavioral: Altered sleep time (including change in righting reflex)

Behavioral: Excitement

Behavioral: Ataxia 		KSRNAM 7,1273,1973
intraperitoneal
mouse 		lethal dose (50 percent kill): 360 mg/kg Peripheral Nerve and Sensation: Flaccid paralysis with appropriate anesthesia

Behavioral: Tetany

Cardiac: Arrythmias (indlucing changes in conduction) 		VCVN1* -,25,1998
intraperitoneal
rat 		lethal dose (50 percent kill): 156 mg/kg Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Respiratory depression

Gastrointestinal: Hypermotility, diarrhea 		KSRNAM 7,1273,1973
intraperitoneal
rat 		lethal dose (50 percent kill): 290 mg/kg N/R FATOAO 48,73,1985
intraperitoneal
rat 		lowest published toxic dose: 88.8 mg/kg Brain and Coverings: Other degenerative changes FATOAO 47,11,1984
intraperitoneal
rat 		lowest published toxic dose: 88 mg/kg Behavioral: Antipsychotic FATOAO 47,11,1984
intravenous
mouse 		lethal dose (50 percent kill): 497 mg/kg Behavioral: Altered sleep time (including change in righting reflex)

Lung, Thorax, or Respiration: Respiratory depression 		KSRNAM 7,1273,1973
intravenous
rat 		lethal dose (50 percent kill): 241 mg/kg Behavioral: Altered sleep time (including change in righting reflex)

Lung, Thorax, or Respiration: Respiratory depression 		KSRNAM 7,1273,1973
oral
dog 		lethal dose (50 percent kill): 500 mg/kg N/R 27ZQAG -,436,1972
oral
human 		lowest published toxic dose: 4,111 mg/kg Behavioral: Tremor

Behavioral: Muscle weakness

Gastrointestinal: Other changes 		NEJMAG 287,867,1972
oral
man 		lowest published toxic dose: 25 gm/kg/4 year- intermittent Behavioral: Tremor

Eye: Miosis (pupilliary constriction) 		JCLPDE 46,292,1985
oral
man 		lowest published toxic dose: 8 mg/kg Gastrointestinal: Nausea or vomiting

Skin: After systemic exposure: Dermatitis, other 		AJPSAO 141,909,1984
oral
man 		lowest published toxic dose: 54 mg/kg Behavioral: Sleep

Behavioral: Hallucinations, distorted perceptions 		NZMJAX 97,23,1984
oral
man 		lowest published toxic dose: 1,080 mg/kg/13 week- intermittent Skin: After systemic exposure: Dermatitis, allergic JCLPDE 47,330,1986
oral
mouse 		lethal dose (50 percent kill): 531 mg/kg N/R RPTOAN 33,266,1970
oral
mouse 		lethal dose (50 percent kill): 531 mg/kg Peripheral Nerve and Sensation: Flaccid paralysis with appropriate anesthesia

Behavioral: Tetany

Cardiac: Arrythmias (indlucing changes in conduction) 		VCVN1* -,25,1998
oral
rat 		lethal dose (50 percent kill): 525 mg/kg Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Respiratory depression

Gastrointestinal: Hypermotility, diarrhea 		KSRNAM 7,1273,1973
oral
rat 		lethal dose (50 percent kill): 553 mg/kg Peripheral Nerve and Sensation: Flaccid paralysis with appropriate anesthesia

Behavioral: Tetany

Cardiac: Arrythmias (indlucing changes in conduction) 		VCVN1* -,25,1998
oral
rabbit 		lethal dose (50 percent kill): 404 mg/kg Peripheral Nerve and Sensation: Flaccid paralysis with appropriate anesthesia

Behavioral: Tetany

Cardiac: Arrythmias (indlucing changes in conduction) 		VCVN1* -,25,1998
oral
woman 		lowest published toxic dose: 36,500 mg/kg/10 year- intermittent Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Kidney, Ureter, and Bladder: Urine volume increased

Endocrine: Diabetes insipidus (nephrogenic or CNS) 		AMDIBO 148,284,1997
oral
woman 		lowest published toxic dose: 612 mg/kg/44 day- intermittent Behavioral: Sleep

Skin: After systemic exposure: Dermatitis, allergic 		AJPSAO 152,956,1995
oral
woman 		lowest published toxic dose: 8,760 mg/kg/2 year- intermittent Endocrine: Thyroid weight (goiter)

Endocrine: Evidence of thyroid hyperfunction 		AJMEAZ 99,575,1995
oral
woman 		lowest published toxic dose: 120 mg/kg/10 day- intermittent Behavioral: Excitement JCLPDE 48,81,1987
subcutaneous
frog 		lethal dose (50 percent kill): 452 mg/kg Peripheral Nerve and Sensation: Flaccid paralysis with appropriate anesthesia

Behavioral: Tetany

Cardiac: Arrythmias (indlucing changes in conduction) 		VCVN1* -,25,1998
subcutaneous
mouse 		lethal dose (50 percent kill): 413 mg/kg N/R RPTOAN 33,266,1970
subcutaneous
mouse 		lethal dose (50 percent kill): 413 mg/kg Peripheral Nerve and Sensation: Flaccid paralysis with appropriate anesthesia

Behavioral: Tetany

Cardiac: Arrythmias (indlucing changes in conduction) 		VCVN1* -,25,1998
subcutaneous
rat 		lethal dose (50 percent kill): 434 mg/kg Eye: Lacrimation

Lung, Thorax, or Respiration: Respiratory depression

Skin and Appendages: Other: Hair 		KSRNAM 7,1273,1973
unreported route
woman 		lowest published toxic dose: 556 mg/kg/32 day Behavioral: Toxic psychosis JAMAAP 213,865,1970


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
rat 		lowest published toxic dose: 600 mg/kg/60 day- intermittent Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) AJANA2 134,97,1972
intraperitoneal
rat 		lowest published toxic dose: 1,600 mg/kg/80 day- intermittent Endocrine: Changes in thyroid weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		AJANA2 136,297,1973
intraperitoneal
rat 		lowest published toxic dose: 1,600 mg/kg/80 day- intermittent Behavioral: Sleep

Gastrointestinal: Hypermotility, diarrhea

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		AJANA2 136,297,1973
oral
child 		lowest published toxic dose: 210 mg/kg/7 day- intermittent Biochemical: Metabolism (intermediary): Other carbohydrates NEROEW 24,359,2001
oral
mammal (species unspecified) 		lowest published toxic dose: 14,560 µg/kg/26 week- intermittent Brain and Coverings: Recordings from specific areas of CNS

Liver: Liver function tests impaired

Blood: Pigmented or nucleated red blood cells 		STGNBT -,155,1999
oral
rat 		lowest published toxic dose: 4,500 mg/kg/30 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Nutritional and Gross Metabolic: Dehydration

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		KSRNAM 7,1278,1973
oral
rat 		lowest published toxic dose: 18,200 mg/kg/26 week- intermittent Endocrine: Changes in adrenal weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		KSRNAM 7,12,1973
oral
rat 		lowest published toxic dose: 36,400 mg/kg/52 week- intermittent Cardiac: Changes in heart weight

Gastrointestinal: Other changes

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		KSRNAM 7,12,1973
oral
rat 		lowest published toxic dose: 1,980 mg/kg/30 day- continuous Endocrine: Evidence of thyroid hypofunction

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) 		HMMRA2 17,109,1985
oral
rat 		lowest published toxic dose: 4.62 gm/kg/5 week- intermittent Brain and Coverings: Other degenerative changes

Biochemical: Metabolism (intermediary): Other proteins

Biochemical: Metabolism (intermediary): Effect on cyclic nucleotides 		NEROEW 25,729,2001
oral
rat 		lowest published toxic dose: 72,000 mg/kg/90 day- intermittent Endocrine: Androgenic

Reproductive: Paternal effects: Testes, epididymis, sperm duct

Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands 		REPTED 17,683,2003
oral
rat 		lowest published toxic dose: 72,000 mg/kg/90 day- intermittent Related to Chronic Data: Changes in prostate weight

Related to Chronic Data: Changes in testicular weight 		REPTED 17,683,2003
oral
rat 		lowest published toxic dose: 99,000 mg/kg/90 day- intermittent Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct

Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands 		REPTED 17,683,2003
oral
woman 		lowest published toxic dose: 60 mg/kg/2 day- intermittent Brain and Coverings: Changes in surface EEG

Behavioral: Tremor

Behavioral: Convulsions or effect on seizure threshold 		AJEMEN 20,570,2002
unreported route
rat 		lowest published toxic dose: 300 mg/kg/3 day- intermittent Kidney, Ureter, and Bladder: Urine volume increased

Blood: Other changes 		FATOAO 47,15,1984


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
TOXICOLOGY REVIEW
DICPBB 8,690,1974
TOXICOLOGY REVIEW
EURNE* 12,361,2002


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 84414;
Number of Industries 8;
Total Number of Facilities 1,035;
Number of Occupations 10;
Total Number of Employees Exposed 6,333
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X6906;
Number of Industries 1;
Total Number of Facilities 3;
Number of Occupations 1;
Total Number of Employees Exposed 198;
Total Number of Female Employees Exposed 151
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 84414;
Number of Industries 17;
Total Number of Facilities 2,182;
Number of Occupations 31;
Total Number of Employees Exposed 39,147;
Total Number of Female Employees Exposed 17,568


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY


REFERENCES:

CODEN
REFERENCE
27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972
56ZJAL "Metal Ions in Biology and Medicine, Proceedings of the International Symposium, 1st, 1990," Collery, P., and Manfait, M., et al., eds., Paris, France, 1990.
AIMEAS Annals of Internal Medicine. (American College of Physicians, 4200 Pine St., Philadelphia, PA 19104) V.1- 1927-
AJANA2 American Journal of Anatomy. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1-192, 1901-91.
AJEMEN American Journal of Emergency Medicine. (WB Saunders, Philadelphia, PA) V.1- 1983-
AJMEAZ American Journal of Medicine. (Technical Pub., 875 Third Ave., New York, NY 10022) V.1- 1946-
AJPSAO American Journal of Psychiatry. (American Psychiatric Assoc., Circulation Dept., 1400 K St., NW, Washington, DC 20005) V.78- 1921-
AMDIBO Annales de Medecine Interne. (Masson Abonnements, B.P.22, F-41354 Vineuil Cedex, France) V.120- 1969-
ANZJB8 Australian and New Zealand Journal of Medicine. (Modern Medicine of Australia Pty., Ltd., 100 Pacific Highway, North Sydney, 2060, Australia) V.1- 1971-
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974-
BJPYAJ British Journal of Psychiatry. (Headley Brothers, Ltd., Ashford, Kent TN24 8HH, UK) V.109- 1963-
BMJOAE British Medical Journal. (British Medical Assoc., BMA House, Tavistock Sq., London WC1H 9JR, UK) V.1- 1857-
CMAJAX Canadian Medical Association Journal. (Canadian Medical Assoc., POB 8650, Ottawa, ON K1G 0G8, Canada) V.1- 1911-
CYTOAN Cytologia. (Japan Pub. Trading Co. (USA), 1255 Howard St., San Francisco, CA 94103) V.1- 1929-
DICPBB Drug Intelligence and Clinical Pharmacy. (POB 42435, Cincinnati, OH 45242) V.3- 1969-
EURNE* European Neuropsychopharmacology (Elsevier Science, P.O.Box 7247-7682,Philadelphia,PA 19170 -7682,USA OR Elsevier Science B.V.,P.O.Box 1270,1000 BG Amsterdam,The Netherlands) V.1- Nov.1990-
FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939-
HAEMAX Haematologica. (Il Pensiero Scientifico Editore, Via Panama 48, I-00198, Rome, Italy) V.1- 1920-
HMMRA2 Hormone and Metabolic Research. (Georg Thieme Verlag, Postfach 732, D-7000 Stuttgart 1, Fed. Rep. Ger.) V.1- 1969-
JAMAAP JAMA, Journal of the American Medical Association. (AMA, 535 N. Dearborn St., Chicago, IL 60610) V.1- 1883-
JCLPDE Journal of Clinical Psychiatry. (Physicians Postgraduate Press, Inc., POB 240008, Memphis, TN 38124) V.39- 1978-
JOPDAB Journal of Pediatrics. (C.V. Mosby Co., 11830 Westline Industrial Dr., St. Louis, MO 63141) V.1- 1932-
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76-
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960-
LANCAO Lancet. (7 Adam St., London WC2N 6AD, UK) V.1- 1823-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NATUAS Nature. (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736) V.1- 1869-
NEJMAG New England Journal of Medicine. (Massachusetts Medical Soc., 10 Shattuck St., Boston, MA 02115) V.198- 1928-
NEROEW Neuropsychopharmacology. (Elsevier Science, 655 Avenue of the Americas, New York, NY 10010) V.1- 1987-
NNAPBA Naunyn-Schmiedebergs Archiv fuer Pharmakologie. (Berlin, Ger.) V.264-271, 1969-71. For publisher information, see NSAPCC.
NTRSDC Nutrition Research. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1981-
NZMJAX New Zealand Medical Journal. (New Zealand Medical Assoc., P.O. Box 156, Wellington, New Zealand) V.1- 1900-
PEDIAU Pediatrics. (American Academy of Pediatrics, P.O. Box 1034, Evanston, IL 60204) V.1- 1948-
PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04-
REPTED Reproductive Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987-
RPTOAN Russian Pharmacology and Toxicology (English Translation). Translation of FATOAO. (Euromed Pub., 33, Woodlands Rd., Surbiton, Surrey, UK) V.30- 1967-
STGNBT "Spravochnik po Toksikologii i Gigienicheskim Normativam (PDK) Potentsial'no Opasnykh Khimicheskikh Veshchestv" Kushneva, V.S., and R.B. Gorshkova, eds. 46, Zhivopisnaya St., 123182, Moscow, Russia, IzdAT 1999
TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968-
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
VCVN1* "Vrednie chemichescie veshestva. Neorganicheskie soedinenia elementov I-IV groopp" (Hazardous substances. Inornanic substances containing I-IV group elements), Filov V.A., Chimia, 1988.
VOONC* Voprosi oncologii (Questions of oncology. Journal of Petrov's Institute of Oncology, B. Zelenina str, 43a, Spb 197110, Russia) V.1- 1955-

Used in treatment of manic-depressive psychoses

NIOSH PROFILE (LITHIUM AND ITS COMPOUNDS), SRC, 4/78

FDA-proprietary drug

RTECS Compound Description:
   Tumorigen
   Drug
   Mutagen
   Reproductive Effector
   Human Data

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