The Registry of Toxic Effects of Chemical Substances

Ligroine

RTECS #: OI6180000

CAS #: 8032-32-4

UPDATE: May 2004 MW: N/R MF: N/R


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. ACUTE TOXICITY DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. Benzine (light petroleum distillate)
  2. Benzoline
  3. Canadol
  4. Ligroin
  5. Painters naphtha
  6. Petroleum ether
  7. Refined solvent naphtha
  1. Skellysolve F
  2. Skellysolve G
  3. VM & P Naphtha
  4. VM & P Naphtha (ACGIH)
  5. VM and P Naphtha
  6. VM&P Naphtha
  7. Varnish marker's naphtha


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
human 		880 ppm/15 minute N/R TXAPA9 32,263,1975


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published toxic concentration: 300 mg/m3/4 hour (1-19 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system

Reproductive: Effects on newborn: Behavioral 		GISAAA 56(9),35,1991


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mouse 		lowest published lethal concentration: 153 gm/m3/31 minute Behavioral: Somnolence (general depressed activity)

Behavioral: Change in motor activity (specific assay) 		BIZEA2 115,235,1921
inhalation
rat 		lethal concentration (50 percent kill): 3,400 ppm/4 hour Behavioral: Convulsions or effect on seizure threshold

Behavioral: Muscle weakness 		TXAPA9 32,263,1975
intravenous
mouse 		lethal dose (50 percent kill): 40 mg/kg N/R PCJOAU 7,765,1973


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 300 ppm DTLVS* TLV/BEI,2003
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Confirmed Animal Carcinogen with Unknown DTLVS* TLV/BEI,2003


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Occupational Exposure Limit - POLAND time-weighted average 500 mg/m3, short term exposure limit 1500 mg/m3, JAN1999


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO VM & P NAPHTHA-air 10 hour time-weighted average 350 mg/m3;
ceiling concentration 1800 mg/m3/15 minute 		NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: M0630;
Number of Industries 21;
Total Number of Facilities 1,437;
Number of Occupations 22;
Total Number of Employees Exposed 10,998
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: M2829;
Number of Industries 459;
Total Number of Facilities 182,022;
Number of Occupations 231;
Total Number of Employees Exposed 2,414,497
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: T0180;
Number of Industries 16;
Total Number of Facilities 1,133;
Number of Occupations 12;
Total Number of Employees Exposed 3,524
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: M0630;
Number of Industries 1;
Total Number of Facilities 5;
Number of Occupations 2;
Total Number of Employees Exposed 1,674;
Total Number of Female Employees Exposed 109
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: T0180;
Number of Industries 337;
Total Number of Facilities 93,614;
Number of Occupations 196;
Total Number of Employees Exposed 1,319,179;
Total Number of Female Employees Exposed 164,513


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as a solvent for lacquers and varnishes and as a rapid-dry paint thinner
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Naphthas, 1550
OSHA ANALYTICAL METHOD #48


REFERENCES:

CODEN
REFERENCE
BIZEA2 Biochemische Zeitschrift. (Berlin, Ger.) V.1-346, 1906-67. For publisher information, see EJBCAI.
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
PCJOAU Pharmaceutical Chemistry Journal (English Translation). Translation of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No.1- 1967-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-

Used as a solvent for lacquers and varnishes and as a rapid-dry paint thinner

RTECS Compound Description:
   Reproductive Effector
   Primary Irritant

ALT CAS #: 8031-06-9
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