The Registry of Toxic Effects of Chemical Substances

Lead (II) nitrate (1:2)

RTECS #: OG2100000

CAS #: 10099-74-8

UPDATE: May 2005 MW: 331.21 MF: N2O6•Pb


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. Lead dinitrate
  2. Lead nitrate
  3. Lead (2+) nitrate
  4. Lead (II) nitrate
  1. Nitrate de plomb (French)
  2. Nitric acid, lead (2+) salt
  3. Plumbous nitrate


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis parenteral
mouse 		200 µg/kg MILEDM 17,29,1981
cytogenetic analysis intravenous
mouse 		12,500 µg/kg ACAEAS 135,185,1989
cytogenetic analysis intraperitoneal
mouse 		10 mg/kg MUREAV 241,305,1990
cytogenetic analysis rat other cell types 300 µmol/L CBINA8 30,237,1980
DNA damage hamster lung 1,700 µmol/L MUREAV 298,97,1992
DNA damage oral
mouse 		0.7 mg/kg TXCYAC 145,201,2000
DNA damage rat Ascites tumor 5 mmol/L JBCHA3 261,3370,1986
DNA inhibition rat liver 100 µmol/L JTEHD6 4,503,1978
micronucleus test intraperitoneal
mouse 		625 µg/kg MUREAV 415,131,1998
mutation in mammalian somatic cells mouse lymphocyte 450 mg/L JTEHD6 9,367,1982
phage inhibition capacity Escherichia coli 320 µmol/L ENMUDM 6,59,1984
sister chromatid exchange hamster ovary 3 µmol/L EMMUEG 23,143,1994
sister chromatid exchange intravenous
mouse 		150 mg/kg EXPADD 36,65,1989
sister chromatid exchange intraperitoneal
mouse 		10 mg/kg EMMUEG 21,229,1993


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
rat 		lowest published toxic dose: 50 mg/kg (3 day pregnant) Reproductive: Effects on fertility: Other measures of fertility BECTA6 25,702,1980
intratesticular
rat 		lowest published toxic dose: 6,624 µg/kg (1 day male) Reproductive: Paternal effects: Testes, epididymis, sperm duct JRPFA4 7,21,1964
intravenous
hamster 		lowest published toxic dose: 25 mg/kg (8 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Specific developmental abnormalities: Musculoskeletal system 		ANREAK 157,358,1967
intravenous
hamster 		lowest published toxic dose: 50 mg/kg (8 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system

Reproductive: Specific developmental abnormalities: Urogenital system

Reproductive: Specific developmental abnormalities: Central nervous system 		ENVRAL 17,325,1978
intravenous
hamster 		lowest published toxic dose: 50 mg/kg (8 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Effects on embryo or fetus: Fetal death 		LAINAW 37,369,1977
intravenous
hamster 		lowest published toxic dose: 50 mg/kg (8 day pregnant) Reproductive: Specific developmental abnormalities: Cardiovascular (circulatory) system

Reproductive: Specific developmental abnormalities: Homeostasis

Reproductive: Other developmental abnormalities 		LAINAW 37,369,1977
intravenous
mouse 		lowest published toxic dose: 100 mg/kg (9 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Extra embryonic structures (e.g., placenta, umbilical cord) 		EXPADD 36,65,1989
intravenous
rat 		lowest published toxic dose: 7,993 µg/kg (17 day pregnant) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) BNEOBV 41,193,1982
intravenous
rat 		lowest published toxic dose: 25 mg/kg (9 day pregnant) Reproductive: Effects on embryo or fetus: Extra embryonic structures (e.g., placenta, umbilical cord)

Reproductive: Specific developmental abnormalities: Body wall

Reproductive: Specific developmental abnormalities: Musculoskeletal system 		JTEHD6 9,1021,1982
intravenous
rat 		lowest published toxic dose: 39,964 µg/kg (17 day pregnant) Reproductive: Maternal effects: Parturition

Reproductive: Effects on newborn: Weaning or lactation index (e.g., # alive at weaning per # alive at day 4)

Reproductive: Effects on newborn: Behavioral 		BNEOBV 41,193,1982
intravenous
rat 		lowest published toxic dose: 25 mg/kg (15 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) NTIS** CONF-771017
intravenous
rat 		lowest published toxic dose: 25 mg/kg (9 day pregnant) Reproductive: Specific developmental abnormalities: Urogenital system TXAPA9 31,72,1975
intravenous
rat 		lowest published toxic dose: 25 mg/kg (15 day pregnant) Reproductive: Effects on embryo or fetus: Fetal death JTEHD6 9,1007,1982
oral
rat 		lowest published toxic dose: 13 gm/kg (6 week male/6 week prior to copulation-3 week after birth) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) JLCMAK 87,273,1976
oral
rat 		lowest published toxic dose: 27 gm/kg (6 week male/6 week prior to copulation-3 week after birth) Reproductive: Effects on newborn: Weaning or lactation index (e.g., # alive at weaning per # alive at day 4) JLCMAK 87,273,1976
oral
rat 		lowest published toxic dose: 43 mg/kg (1-22 day pregnant/21 day after birth) Reproductive: Effects on newborn: Behavioral NTOTDY 7,499,1985
oral
rat 		lowest published toxic dose: 36 mg/kg (10 day male/10 day prior to copulation-16 day pregnant) Reproductive: Specific developmental abnormalities: Central nervous system NETEEC 10,453,1988
oral
rat 		lowest published toxic dose: 38 mg/kg (22 week prior to copulation) Reproductive: Specific developmental abnormalities: Central nervous system BEBMAE 128,667,1999
oral
rat 		lowest published toxic dose: 200 mg/kg (18 day pregnant) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)

Reproductive: Effects on newborn: Biochemical and metabolic

Reproductive: Effects on newborn: Physical 		BEBMAE 129(1),28,2000
subcutaneous
mouse 		lowest published toxic dose: 6,624 µg/kg (30 day male) Reproductive: Paternal effects: Testes, epididymis, sperm duct JRPFA4 7,21,1964
subcutaneous
mouse 		lowest published toxic dose: 25 mg/kg (10 day pregnant) Reproductive: Other effects on female

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) 		AECTCV 42,93,2002


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lethal dose (50 percent kill): 74 mg/kg N/R BECTA6 9,80,1973
intraperitoneal
rat 		lowest published lethal dose: 270 mg/kg N/R EQSSDX 1,1,1975
intravenous
rat 		lethal dose (50 percent kill): 93 mg/kg N/R PSEBAA 92,331,1956
intravenous
rat 		lowest published toxic dose: 5 mg/kg Gastrointestinal: Ulceration or bleeding from small intestine

Blood: Changes in cell count (unspecified)

Blood: Changes in erythrocyte (RBC) count 		JJTHEC 9,1007,1982
intravenous
rat 		lowest published toxic dose: 25 mg/kg Kidney, Ureter, and Bladder: Changes in kidney weight

Endocrine: Changes in spleen weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		JJTHEC 9,1007,1982
oral
guinea pig 		lowest published lethal dose: 500 mg/kg Behavioral: Convulsions or effect on seizure threshold

Blood: Pigmented or nucleated red blood cells

Nutritional and Gross Metabolic: Body temperature decrease 		AHBAAM 125,273,1941
unreported route
rat 		lethal dose (50 percent kill): 3,613 mg/kg N/R GISAAA 50(3),57,1985


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
duck 		lowest published toxic dose: 43 mg/kg/12 week- continuous Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes JTEHD6 1,929,1976
oral
mouse 		lowest published toxic dose: 97 mg/kg/27 day- continuous Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes ARTODN 45,197,1980
oral
rat 		lowest published toxic dose: 1,200 mg/kg/60 day- intermittent Blood: Other changes KHZDAN 11,157,1968
subcutaneous
mouse 		lowest published toxic dose: 56 mg/kg/7 day- intermittent Endocrine: Effect on menstrual cycle ABICR* 15,121,1972
subcutaneous
rat 		lowest published toxic dose: 7 gm/kg/7 day- intermittent Blood: Pigmented or nucleated red blood cells

Blood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases 		GTPZAB 16(5),54,1972
subcutaneous
rat 		lowest published toxic dose: 140 mg/kg/4 week- intermittent Kidney, Ureter, and Bladder: Changes in both tubules and glomeruli

Kidney, Ureter, and Bladder: Renal function tests depressed

Kidney, Ureter, and Bladder: Other changes in urine composition 		ETOPFR 17,159,2004


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.05 mg(Pb)/m3; animal carcinogen DTLVS* TLV/BEI,1999
International Agency for Research on Cancer (IARC) Cancer Review Animal Inadequate Evidence IMEMDT 23,325,1980
TOXICOLOGY REVIEW
85DHAX Pb,254,1972


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Exposure Limit - ARAB Republic of Egypt time-weighted average 0.05 mg(Pb)/m3, JAN1993
Occupational Exposure Limit - AUSTRALIA time-weighted average 0.15 mg(Pb)/m3, JAN1993
Occupational Exposure Limit - AUSTRIA MAK 0.1 mg(Pb)/m3, JAN1993
Occupational Exposure Limit - BELGIUM time-weighted average 0.15 mg(Pb)/m3, JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 0.1 mg(Pb)/m3, JAN1999
Occupational Exposure Limit - FINLAND time-weighted average 0.1 mg(Pb)/m3, JAN1999
Occupational Exposure Limit - FRANCE VME 0.15 mg(Pb)/m3, JAN1999
Occupational Exposure Limit - GERMANY MAK 0.1 mg(Pb)/m3, JAN1999
Occupational Exposure Limit - HUNGARY short term exposure limit 0.04 mg(Pb)/m3, Carcinogen, JAN1993
Occupational Exposure Limit - JAPAN Occupational Exposure Limit 0.1 mg(Pb)/m3, JAN1999
Occupational Exposure Limit - NORWAY time-weighted average 0.05 mg(Pb)/m3, JAN1999
Occupational Exposure Limit - POLAND MAC(time-weighted average) 0.05 mg(Pb)/m3, JAN1999
Occupational Exposure Limit - RUSSIA short term exposure limit 0.005 ppm (0.01 mg(Pb)/m3), JAN1993
Occupational Exposure Limit - SWEDEN NGV 0.05 mg(Pb)/m3 (resp. dust), JAN1999
Occupational Exposure Limit - SWEDEN NGV 0.1 mg(Pb)/m3 (total dust), JAN1999
Occupational Exposure Limit - SWITZERLAND MAK- week 0.1 mg(Pb)/m3, JAN1999
Occupational Exposure Limit - THAILAND time-weighted average 0.2 mg(Pb)/m3, JAN1993
Occupational Exposure Limit - TURKEY time-weighted average 0.2 mg(Pb)/m3, JAN1993
Occupational Exposure Limit - UNITED KINGDOM LTEL 0.15 mg(Pb)/m3, JAN1993
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 0.05 mg(Pb)/m3;
animal carcinogen
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 0.05 mg(Pb)/m3;
animal carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO LEAD, INORGANIC-air 10 hour time-weighted average <0.1 mg(Pb)/m3 NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 84473;
Number of Industries 4;
Total Number of Facilities 112;
Number of Occupations 5;
Total Number of Employees Exposed 420
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 84473;
Number of Industries 18;
Total Number of Facilities 450;
Number of Occupations 20;
Total Number of Employees Exposed 11,440;
Total Number of Female Employees Exposed 4,246


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as a mordant, a chemical reagent, and in production of matches, and pyrotechnics
NTP 11th Report on Carcinogens,2004:Reasonably anticipated to be a human carcinogen


REFERENCES:

CODEN
REFERENCE
85DHAX "Medical and Biologic Effects of Environmental Pollutants Series," Washington, DC, National Academy of Sciences, 1972-77
ABICR* Acta Biologica Cracoviensia. ("Vesalius" University Medical Publisher: ul. Wislisko 1, 31-538 Cracow, Poland) V.38- 1996-
ACAEAS Acta Anaesthesiologica. (Padua, Italy) V.1-22, 1950-71. For publisher information, see AANIBO.
AECTCV Archives of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 070944) V.1- 1973-
AHBAAM Archiv fuer Hygiene und Bakteriologie. (Munich, Fed. Rep. Ger.) V.101-154, 1929-71. For publisher information, see ZHPMAT.
ANREAK Anatomical Record. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1906/08-
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974-
BEBMAE Byulleten' Eksperimental'noi Biologii i Meditsiny. Bulletin of Experimental Biology and Medicine. For English translation, see BEXBAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
BECTA6 Bulletin of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1966-
BNEOBV Biology of the Neonate. (S. Karger Pub., Inc., 79 Fifth Ave., New York, NY 10003) V.15- 1970-
CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1969-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG.
ENVRAL Environmental Research. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1967-
EQSSDX Environmental Quality and Safety, Supplement. (Stuttgart, Fed. Rep. Ger.) V.1-5, 1975-76. Discontinued.
ETOPFR Environmental Toxicology and Pharmacology (Elsevier Science, P.O.Box 7247-7682,Philadelphia,PA 19170 -7682,USA OR Elsevier Science B.V.,P.O.Box 1270,1000 BG Amsterdam,The Netherlands) V.1- Feb.1996-
EXPADD Experimental Pathology (1981). (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.19- 1981-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
JBCHA3 Journal of Biological Chemistry. (428 E. Preston St., Baltimore, MD 21202) V.1- 1905-
JJTHEC Japanese Journal of Toxicology and Environmental Health. (Nippon Yakugakkai, 2-12-15 Shibuya, Shibuya-ku, Tokyo 150, Japan) V.38- 1992-
JLCMAK Journal of Laboratory and Clinical Medicine. (C.V. Mosby Co., 11830 Westline Industrial Dr., St. Louis, MO 63141) V.1- 1915-
JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1960-
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76-
KHZDAN Khigiena i Zdraveopazvane. Hygiene and Sanitation. (Hemus, Blvd. Russki 6, Sofia, Bulgaria) V.9- 1966-
LAINAW Laboratory Investigation. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1952-
MILEDM Microbios Letters. (Faculty Press, 88 Regent St., Cambridge, UK) V.1- 1976-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NETEEC Neurotoxicology and Teratology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.9- 1987-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
NTOTDY Neurobehavioral Toxicology and Teratology. (Fayetteville, NY) V.3-8, 1981-86. For publisher information, see NETEEC.
PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973-

Used as a mordant, a chemical reagent, and in production of matches, and pyrotechnics

RTECS Compound Description:
   Tumorigen
   Mutagen
   Reproductive Effector

ALT CAS #: 18256-98-9
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