The Registry of Toxic Effects of Chemical Substances

Lead, bis (dimethyldithiocarbamato) -

RTECS #: OF8850000

CAS #: 19010-66-3

UPDATE: April 1999 MW: 447.63 MF: C6H12N2S4•Pb


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. TUMORIGENIC DATA:
  4. REVIEWS:
  5. NIOSH DOCUMENTATION AND SURVEILLANCE:
  6. STATUS IN FEDERAL AGENCIES:
  7. REFERENCES:

SYNONYMS:

  1. Bis (dimethylcarbamodithioato - S,S') lead
  2. Bis (dimethyldithiocarbamato) lead
  3. Carbamic acid, dimethyldithio - , lead salt
  4. Lead, bis (dimethylcarbamodithioato - S,S') - , (T - 4) - (9CI)
  1. Lead dimethyldithiocarbamate
  2. Methyl ledate
  3. NCI - C02891


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
mutation in microorganisms Salmonella typhimurium 100 µg/plate (+enzymatic activation step) ENMUDM 5(Suppl 1),3,1983
mutation in microorganisms Salmonella typhimurium 33 µg/plate (-enzymatic activation step) NTPTB* JAN1982


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
subcutaneous
mouse 		lowest published toxic dose: 1,000 mg/kg Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Blood: Tumors 		NTIS** PB223-159


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
International Agency for Research on Cancer (IARC) Cancer Review Animal Inadequate Evidence IMEMDT 12,131,1976
International Agency for Research on Cancer (IARC) Cancer Review Human Inadequate Evidence IMSUDL 7,230,1987
International Agency for Research on Cancer (IARC) Cancer Review Group 3 IMSUDL 7,230,1987


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 83298;
Number of Industries 1;
Total Number of Facilities 27;
Number of Occupations 14;
Total Number of Employees Exposed 1,346
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 83298;
Number of Industries 1;
Total Number of Facilities 16;
Number of Occupations 3;
Total Number of Employees Exposed 4,428;
Total Number of Female Employees Exposed 80


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as an accelerator in the rubber-processing industry
NCI Carcinogenesis Bioassay (feed);no evidence:mouse,rat NCITR* NCI-TR-151,1979


REFERENCES:

CODEN
REFERENCE
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG.
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979-
NCITR* National Cancer Institute Carcinogenesis Technical Report Series. (Bethesda, MD) No.0-205. For publisher information, see NTPTR*.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
NTPTB* NTP Technical Bulletin. (National Toxicology Program, Landow Bldg. 3A-06, 7910 Woodmont Ave., Bethesda, MD 20205)

Used as an accelerator in the rubber-processing industry

RTECS Compound Description:
   Agricultural Chemical
   Tumorigen
   Mutagen

 Click Here for Additional Information about RTECS