The Registry of Toxic Effects of Chemical Substances

Lactic acid

RTECS #: OD2800000

CAS #: 50-21-5

UPDATE: August 2004 MW: 90.09 MF: C3H6O3


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. REPRODUCTIVE EFFECTS DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. REVIEWS:
  8. STANDARDS AND REGULATIONS:
  9. NIOSH DOCUMENTATION AND SURVEILLANCE:
  10. STATUS IN FEDERAL AGENCIES:
  11. REFERENCES:

SYNONYMS:

  1. Ethylidenelactic acid
  2. 1 - Hydroxyethanecarboxylic acid
  3. 2 - Hydroxypropanoic acid
  4. alpha - Hydroxypropionic acid
  5. 2 - Hydroxypropionic acid
  6. DL - Lactic acid
  7. Kyselina 2 - hydroxypropanova (Czech)
  8. Kyselina mlecna (Czech)
  1. Milchsaure (German)
  2. Milk acid
  3. Ordinary lactic acid
  4. Propanoic acid, 2 - hydroxy -
  5. Propel
  6. Propionic acid, 2 - hydroxy -
  7. Racemic lactic acid
  8. SY - 83


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		750 µg severe AJOPAA 29,1363,1946
skin
human 		10%/48 hour BJDEAZ 17,294,1987
skin
rabbit 		5 mg/24 hour severe 85JCAE -,656,1986
skin
rabbit 		100 mg/24 hour moderate IJTOFN 17(Suppl 1),71,1998


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis hamster ovary 10 mmol/L MUREAV 240,195,1990
mutation in microorganisms Escherichia coli 210 ppm/3 hour (-enzymatic activation step) AMNTA4 85,119,1951


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lowest published toxic dose: 5,700 mg/kg (6-15 day pregnant) Reproductive: Other effects on female

Reproductive: Specific developmental abnormalities: Musculoskeletal system 		RCOCB8 77,95,1992


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
guinea pig 		lethal dose (50 percent kill): 1,810 mg/kg N/R JIHTAB 23,259,1941
oral
mouse 		lethal dose (50 percent kill): 4,875 mg/kg N/R FAONAU 40,144,1967
oral
quail 		lethal dose (50 percent kill): >2,250 mg/kg N/R FMCHA2 -,C252,1991
oral
rat 		lethal dose (50 percent kill): 3,543 mg/kg N/R FMCHA2 -,C252,1991
oral
rabbit 		lowest published lethal dose: 5 gm/kg N/R IECHAD 15,628,1923
rectal
rabbit 		lowest published lethal dose: 600 mg/kg N/R CRSBAW 83,136,1920
skin
rabbit 		lethal dose (50 percent kill): >2 gm/kg N/R FMCHA2 -,C252,1991


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
skin
rat 		lowest published toxic dose: 57,590 mg/kg/13 week- intermittent Brain and Coverings: Changes in brain weight

Kidney, Ureter, and Bladder: Changes in bladder weight

Blood: Other changes 		IJTOFN 17(Suppl 1),71,1998


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
TOXICOLOGY REVIEW
MUREAV 539,77,2003


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Active registration RBREV* -,378,1998


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 80595;
Number of Industries 56;
Total Number of Facilities 10,707;
Number of Occupations 50;
Total Number of Employees Exposed 68,982
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 80595;
Number of Industries 39;
Total Number of Facilities 10,134;
Number of Occupations 58;
Total Number of Employees Exposed 107,962;
Total Number of Female Employees Exposed 63,436


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as an antiseptic agent
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NTP Carcinogenesis studies; selected, October 2000


REFERENCES:

CODEN
REFERENCE
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
AJOPAA American Journal of Ophthalmology. (Ophthalmic Pub. Co., 435 N. Michigan Ave., Suite 1415, Chicago, IL 60611) Series 3: V.1- 1918-
AMNTA4 American Naturalist. (Univ. of Chicago Press, Journals Div., POB 37005, Chicago, IL 60637) V.1- 1867-
BJDEAZ British Journal of Dermatology. (Blackwell Scientific Pub. Ltd., POB 88, Oxford, UK) V.63- 1951-
CRSBAW Comptes Rendus des Seances de la Societe de Biologie et de Ses Filiales. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1849-
FAONAU FAO Nutrition Meetings Report Series. (Rome, Italy) No.?-57, 1948-77. Discontinued.
FMCHA2 Farm Chemicals Handbook. (Meister Pub., 37841 Euclid Ave., Willoughy, OH 44094)
IECHAD Industrial and Engineering Chemistry. (Washington, DC) V.15-62, 1923-70. For publisher information, see CHMTBL.
IJTOFN International Journal of Toxicology. (Taylor & Francis, 47 Runway Rd., Suite g, Levittown, PA 19057) V.16- 1997-
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU.
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
RCOCB8 Research Communications in Chemical Pathology and Pharmacology. (PJD Pub. Ltd., P.O. Box 966, Westbury, NY 11590) V.1- 1970-

Used as an antiseptic agent

NIOSH PROFILE (LEATHER TANNING), SRI, 2/77

FDA-over the counter drug

RTECS Compound Description:
   Agricultural Chemical
   Tumorigen
   Mutagen
   Reproductive Effector
   Human Data
   Primary Irritant

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