The Registry of Toxic Effects of Chemical Substances

Ketene

RTECS #: OA7700000

CAS #: 463-51-4

UPDATE: November 2004 MW: 42.04 MF: C2H2O


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. ACUTE TOXICITY DATA:
  3. REVIEWS:
  4. STANDARDS AND REGULATIONS:
  5. NIOSH DOCUMENTATION AND SURVEILLANCE:
  6. STATUS IN FEDERAL AGENCIES:
  7. REFERENCES:

SYNONYMS:

  1. Ethenone (9CI)
  2. Carbomethene
  1. Keto - ethylene
  2. Ketene (ACGIH:OSHA)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
cat 		lowest published lethal concentration: 750 ppm/10 minute Lung, Thorax, or Respiration: Acute pulmonary edema

Lung, Thorax, or Respiration: Other changes

Gastrointestinal: Changes in structure or function of salivary glands 		JIHTAB 31,209,1949
inhalation
guinea pig 		lowest published lethal concentration: 53 ppm/2 hour Lung, Thorax, or Respiration: Acute pulmonary edema

Lung, Thorax, or Respiration: Other changes 		JIHTAB 31,209,1949
inhalation
monkey 		lowest published lethal concentration: 200 ppm/10 minute Eye: Ptosis

Lung, Thorax, or Respiration: Acute pulmonary edema

Lung, Thorax, or Respiration: Other changes 		JIHTAB 31,209,1949
inhalation
mouse 		lowest published lethal concentration: 23 ppm/30 minute Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Dyspnea 		JIHTAB 31,209,1949
inhalation
rabbit 		lowest published lethal concentration: 53 ppm/2 hour Lung, Thorax, or Respiration: Acute pulmonary edema

Lung, Thorax, or Respiration: Other changes 		JIHTAB 31,209,1949


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.5 ppm DTLVS* TLV/BEI,2002
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.5 ppm;short term exposure limit 1.5 ppm DTLVS* TLV/BEI,2003
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value short term exposure limit 1.5 ppm DTLVS* TLV/BEI,2002


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 0.5 ppm (0.9 mg/m3) DTLVS* 3,143,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 0.5 ppm (0.9 mg/m3) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 0.5 ppm (0.9 mg/m3) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 0.5 ppm (0.9 mg/m3) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 0.5 ppm (0.9 mg/m3) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - ARAB Republic of Egypt time-weighted average 0.5 ppm (0.9 mg/m3), JAN1993
Occupational Exposure Limit - AUSTRALIA time-weighted average 0.5 ppm (0.9 mg/m3), short term exposure limit 1.5 ppm, JAN1993
Occupational Exposure Limit - AUSTRIA MAK 0.5 ppm (0.9 mg/m3), JAN1999
Occupational Exposure Limit - BELGIUM time-weighted average 0.5 ppm (0.89 mg/m3), short term exposure limit 1.5 ppm, JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 0.5 ppm (0.9 mg/m3), JAN1999
Occupational Exposure Limit - FINLAND short term exposure limit 0.5 ppm (0.9 mg/m3), JAN1999
Occupational Exposure Limit - FRANCE VME 0.5 ppm (0.9 mg/m3), JAN1999
Occupational Exposure Limit - GERMANY MAK 0.5 ppm (0.9 mg/m3), JAN1999
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 0.9 mg/m3, 2003
Occupational Exposure Limit - NORWAY time-weighted average 0.5 ppm, JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 0.5 ppm (0.9 mg/m3), JAN1999
Occupational Exposure Limit - POLAND MAC(time-weighted average) 0.5 mg/m3, MAC(short term exposure limit) 1.5 mg/m3, JAN1999
Occupational Exposure Limit - SWITZERLAND MAK- week 0.5 ppm (0.9 mg/m3), KZG- week 1 ppm (1.8 mg/m3), JAN1999
Occupational Exposure Limit - TURKEY time-weighted average 0.5 ppm (0.9 mg/m3), JAN1993
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 0.5 ppm (0.87 mg/m3), short term exposure limit 0.5 ppm (2.6 mg/m3), SEP2000
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

short term exposure limit 1.5 ppm
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
short term exposure limit 1.5 ppm


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO KETENE-air 10 hour time-weighted average 0.5 ppm;
short term exposure limit 1.5 ppm 		NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 41840;
Number of Industries 1;
Total Number of Facilities 33;
Number of Occupations 1;
Total Number of Employees Exposed 66


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used for synthesis of various organic compounds
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU.
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.

Used for synthesis of various organic compounds

NIOSH PROFILE (ALDEHYDES), SRC, 4/78

NIOSH PROFILE (ALDEHYDES), SRI, 2/77

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