The Registry of Toxic Effects of Chemical Substances
Kerosene |
UPDATE: November 2004 | MW: N/R | MF: N/R |
SYNONYMS: | |
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SKIN AND EYE IRRITATION DATA AND REFERENCES: | |||
ROUTE/ ORGANISM | DOSE |
EFFECT | REFERENCE |
skin rabbit | 500 mg | severe | ATDAEI 1,30,1990 |
skin rabbit | 1,00%/24 hour | moderate | VCVPS* -,61,1998 |
MUTATION DATA AND REFERENCES: | |||
SYSTEM TEST |
ROUTE/ ORGANISM/ TISSUE | DOSE | REFERENCE |
mutation in microorganisms | Salmonella typhimurium | 25 無/plate (+enzymatic activation step) | CBTOE2 2,63,1986 |
REPRODUCTIVE EFFECTS DATA AND REFERENCES: | |||
ROUTE/ ORGANISM | DOSE |
EFFECT | REFERENCE |
N/R | N/R | N/R | N/R |
TUMORIGENIC DATA AND REFERENCES: | |||
ROUTE/ ORGANISM | DOSE |
EFFECT | REFERENCE |
N/R | N/R | N/R | N/R |
ACUTE TOXICITY DATA AND REFERENCES: | |||
ROUTE/ ORGANISM | DOSE |
EFFECT | REFERENCE |
inhalation dog | lowest published toxic concentration: 2,500 mg/m3/2 hour | N/R | VCVPS* -,59,1998 |
inhalation dog | lowest published toxic concentration: 2,500 mg/m3/2 hour |
Behavioral: Tremor Behavioral: Alteration of classical conditioning | VCVPS* -,59,1998 |
inhalation rat | lethal concentration : >5 gm/m3/4 hour | Behavioral: Somnolence (general depressed activity) | ATDAEI 1,30,1990 |
intraperitoneal rat | lowest published lethal dose: 10,700 mg/kg | N/R | TXAPA9 1,156,1959 |
intraperitoneal rabbit | lethal dose (50 percent kill): 6,600 mg/kg |
Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi Lung, Thorax, or Respiration: Emphysema Lung, Thorax, or Respiration: Chronic pulmonary edema or congestion | AIMEAS 21,803,1944 |
intratracheal dog | lowest published lethal dose: 800 mg/kg |
Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi Lung, Thorax, or Respiration: Acute pulmonary edema | AJMSA9 221,531,1951 |
intratracheal rat | lethal dose (50 percent kill): 800 mg/kg |
Behavioral: Convulsions or effect on seizure threshold Lung, Thorax, or Respiration: Dyspnea Lung, Thorax, or Respiration: Cyanosis | TXAPA9 1,462,1959 |
intratracheal rabbit | lethal dose (50 percent kill): 200 mg/kg | N/R | TXAPA9 3,689,1961 |
intravenous dog | lowest published lethal dose: 200 mg/kg |
Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi Lung, Thorax, or Respiration: Acute pulmonary edema | AJMSA9 221,531,1951 |
intravenous man | lowest published toxic dose: 403 mg/kg |
Behavioral: Somnolence (general depressed activity) Behavioral: Hallucinations, distorted perceptions | CTOXAO 10,283,1977 |
intravenous rabbit | lethal dose (50 percent kill): 180 mg/kg |
Lung, Thorax, or Respiration: Respiratory stimulation Behavioral: Tremor Behavioral: Coma | AIMEAS 21,803,1944 |
oral dog | lowest published lethal dose: 4 gm/kg |
Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi Lung, Thorax, or Respiration: Acute pulmonary edema | AJMSA9 221,531,1951 |
oral domestic animal | lowest published toxic dose: 10 mL/kg |
Behavioral: Muscle weakness Gastrointestinal: Decreased motility or constipation Nutritional and Gross Metabolic: Body temperature increase | VHTODE 42,354,2000 |
oral domestic animal | lowest published toxic dose: 20 mL/kg |
Cardiac: Change in rate Lung, Thorax, or Respiration: Cough | VHTODE 42,354,2000 |
oral guinea pig | lethal dose (50 percent kill): 20 gm/kg |
Behavioral: Muscle weakness Lung, Thorax, or Respiration: Respiratory stimulation Endocrine: Hypoglycemia | AIMEAS 21,803,1944 |
oral human | lowest published toxic concentration: 5.7 mg/kg | N/R | VCVPS* -,60,1998 |
oral human | lowest published toxic concentration: 5.7 mg/kg |
Lung, Thorax, or Respiration: Cough Lung, Thorax, or Respiration: Other changes Gastrointestinal: Nausea or vomiting | VCVPS* -,60,1998 |
oral man | lowest published toxic dose: 3,570 mg/kg |
Lung, Thorax, or Respiration: Cough Gastrointestinal: Nausea or vomiting Nutritional and Gross Metabolic: Body temperature increase | TORAAK 15,263,1966 |
oral man | lowest published lethal dose: 500 mg/kg | N/R | YAKUD5 22,883,1980 |
oral rat | lethal dose : >5 gm/kg |
Behavioral: Somnolence (general depressed activity) Gastrointestinal: Hypermotility, diarrhea | ATDAEI 1,30,1990 |
oral rat | lethal dose (50 percent kill): 15 gm/kg | Skin: After topical application: Corrosive | VCVPS* -,59,1998 |
oral rabbit | lethal dose (50 percent kill): 2,835 mg/kg |
Behavioral: Muscle weakness Lung, Thorax, or Respiration: Respiratory stimulation Endocrine: Hypoglycemia | AIMEAS 21,803,1944 |
subcutaneous rat | lowest published toxic concentration: 5 mg/kg |
Lung, Thorax, or Respiration: Acute pulmonary edema Blood: Hemorrhage | VCVPS* -,60,1998 |
skin rabbit | lethal dose : >2 gm/kg | N/R | ATDAEI 1,30,1990 |
unreported route man | lowest published lethal dose: 1,176 mg/kg | N/R | 85DCAI 2,73,1970 |
unreported route rat | lowest published lethal dose: 2 mg/kg | Gastrointestinal: Peritonitis | VCVPS* -,60,1998 |
unreported route rat | lowest published toxic concentration: 2 mg/kg |
Lung, Thorax, or Respiration: Cough Lung, Thorax, or Respiration: Other changes Gastrointestinal: Nausea or vomiting | VCVPS* -,60,1998 |
OTHER MULTIPLE DOSE DATA AND REFERENCES: | |||
ROUTE/ ORGANISM | DOSE |
EFFECT | REFERENCE |
inhalation cat | lowest published toxic concentration: 500 mg/m3/4 week- continuous |
Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi Blood: Changes in leukocyte (WBC) count | VCVPS* -,60,1998 |
inhalation guinea pig | lowest published toxic concentration: 20,400 mg/m3/21 day- intermittent |
Vascular: Other changes Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical: Metabolism (intermediary): Lipids including transport | VCVPS* -,60,1998 |
inhalation human | lowest published toxic concentration: 250 mg/m3/4 year- intermittent |
Behavioral: Excitement Behavioral: Irritability | VCVPS* -,61,1998 |
inhalation human | lowest published toxic concentration: 0.15 mg/m3/5 year- intermittent | Lung, Thorax, or Respiration: Fibrosis (interstitial) | VCVPS* -,61,1998 |
inhalation mouse | lowest published toxic concentration: 500 mg/m3/4 week- continuous |
Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi Blood: Changes in leukocyte (WBC) count | VCVPS* -,60,1998 |
inhalation rat | lowest published toxic concentration: 500 mg/m3/4 week- continuous |
Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi Blood: Changes in leukocyte (WBC) count | VCVPS* -,60,1998 |
inhalation rat | lowest published toxic concentration: 300 mg/m3/12 week- intermittent |
Blood: Normocytic anemia Blood: Luekopenia | VCVPS* -,61,1998 |
inhalation rabbit | lowest published toxic concentration: 500 mg/m3/4 week- continuous |
Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi Blood: Changes in leukocyte (WBC) count | VCVPS* -,60,1998 |
inhalation rabbit | lowest published toxic concentration: 300 mg/m3/12 week- intermittent |
Blood: Normocytic anemia Blood: Luekopenia | VCVPS* -,61,1998 |
oral rat | lowest published toxic dose: 540 gm/kg/90 day- intermittent |
Liver: Changes in liver weight Endocrine: Changes in adrenal weight Endocrine: Antidiuresis | BCTKAG 21,187,1988 |
oral rat | lowest published toxic dose: 405 gm/kg/17 week- intermittent |
Skin: After systemic exposure: Dermatitis, other Skin and Appendages: Other: Hair | VCVPS* -,61,1998 |
subcutaneous rat | lowest published toxic dose: 84 gm/kg/35 day- intermittent |
Liver: Changes in liver weight Endocrine: Changes in spleen weight Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) | ENVRAL 35,516,1984 |
subcutaneous rat | lowest published toxic dose: 11.9 gm/kg/35 day- intermittent |
Liver: Changes in liver weight Endocrine: Changes in spleen weight Liver: Multiple effects | VCVPS* -,61,1998 |
skin rabbit | lowest published toxic dose: 4,500 mg/kg/3 week- intermittent |
Blood: Pigmented or nucleated red blood cells Skin: After systemic exposure: Dermatitis, other Nutritional and Gross Metabolic: Weight loss or decreased weight gain | NTIS** OTS0533973 |
skin rabbit | lowest published toxic dose: 2,400 mg/kg/28 day- intermittent |
Endocrine: Changes in spleen weight Skin: After systemic exposure: Dermatitis, other Skin and Appendages: Other: Hair | NTIS** OTS0541008 |
REVIEWS: | ||
ORGANIZATION | STANDARD |
REFERENCE |
International Agency for Research on Cancer (IARC) Cancer Review | Animal Limited Evidence | IMEMDT 45,39,1989 |
TOXICOLOGY REVIEW |
| MUREAV 543,201,2003 |
STANDARDS AND REGULATIONS: | ||
ORGANIZATION | STANDARD |
REFERENCE |
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 | PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION | FEREAC 54,7740,1989 |
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF | PESTICIDES: Cancelled | RBREV* -,225,1998 |
Occupational Exposure Limit - POLAND | MAC(time-weighted average) 100 mg/m3, MAC(short term exposure limit) 300 mg/m3, JAN1999 |
NIOSH DOCUMENTATION AND SURVEILLANCE: | ||
ORGANIZATION | STANDARD or SURVEY |
REFERENCE |
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO KEROSENE-air | 10 hour time-weighted average 100 mg/m3 | NIOSH* DHHS #92-100,1992 |
National Occupational Exposure Survey 1983 |
National Occupational Exposure Survey 1983: Hazard Code: T1768![]() Number of Industries 321; Total Number of Facilities 69,564; Number of Occupations 186; Total Number of Employees Exposed 1,075,728; Total Number of Female Employees Exposed 96,255 | |
National Occupational Exposure Survey 1983 |
National Occupational Exposure Survey 1983: Hazard Code: X6889![]() Number of Industries 1; Total Number of Facilities 22; Number of Occupations 3; Total Number of Employees Exposed 790 |
STATUS IN FEDERAL AGENCIES: | |
ORGANIZATION |
REFERENCE |
ATSDR TOXICOLOGY PROFILE (NTIS** PB/95/264222/AS) | |
EPA TSCA Section 8(b) CHEMICAL INVENTORY | |
EPA TSCA Section 8(d) unpublished health/safety studies | |
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-8968 | |
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001 | |
NIOSH Analytical Method, 1994: Naphthas, 1550 |
REFERENCES: | |
CODEN |
REFERENCE |
85DCAI | "Poisoning; Toxicology, Symptoms, Treatments," 2nd ed., Arena, J.M., Springfield, IL, C.C. Thomas, 1970 |
AIMEAS | Annals of Internal Medicine. (American College of Physicians, 4200 Pine St., Philadelphia, PA 19104) V.1- 1927- |
AJMSA9 | American Journal of the Medical Sciences. (Slack Inc., 6900 Grove Rd., Thorofare, NJ 08086) New series: V.1- 1841- |
ATDAEI | Acute Toxicity Data. Journal of the American College of Toxicology, Part B. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1- 1990- |
BCTKAG | Bromatologia i Chemia Toksykologiczna. (Ars Polona, POB 1001, 00-068 Warsaw 1, Poland) V.4- 1971- |
CBTOE2 | Cell Biology and Toxicology. (Princeton Scientific Pub., Inc., 301 N. Harrison St., CN 5279, Princeton, NJ 08540) V.1- 1984- |
CTOXAO | Clinical Toxicology. (New York, NY) V.1-18, 1968-81. For publisher information, see JTCTDW. |
ENVRAL | Environmental Research. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1967- |
FEREAC | Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- |
IMEMDT | IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- |
MUREAV | Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- |
NIOSH* | National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. |
NTIS** | National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. |
RBREV* | Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998 |
TORAAK | El Torax. (Montevideo, Uruguay) V.1- 1952- |
TXAPA9 | Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- |
VCVPS* | "Vrednie chemichescie veshestva. Prirodnie organicheskie soedinenia" (Hazardous substances. Nature products.) Volkova N.V. et al., Sankt-Peterburg, 1998. |
VHTODE | Veterinary and Human Toxicology. (American College of Veterinary and Comparative Toxicology, Publication Office, Comparative Toxicology, Manhattan, KS 66506) V.19- 1977- |
YAKUD5 | Gekkan Yakuji. Pharmaceuticals Monthly. (Yakugyo Jihosha, Inaoka Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan) V.1- 1959- |