The Registry of Toxic Effects of Chemical Substances

Isopropylamine

RTECS #: NT8400000

CAS #: 75-31-0

UPDATE: November 2004 MW: 59.13 MF: C3H9N


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. ACUTE TOXICITY DATA:
  4. REVIEWS:
  5. STANDARDS AND REGULATIONS:
  6. NIOSH DOCUMENTATION AND SURVEILLANCE:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. 2 - Amino - propaan (Dutch)
  2. 2 - Aminopropan (German)
  3. 2 - Aminopropane
  4. 2 - Amino - propano (Italian)
  5. Isopropilamina (Italian)
  6. Isopropylamine (ACGIH:OSHA)
  1. 1 - Methylethylamine
  2. Monoisopropylamine
  3. 2 - Propanamine
  4. Propane, 2 - amino -
  5. sec - Propylamine
  6. 2 - Propylamine


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		100 µL severe NTIS** OTS0542011
skin
rabbit 		345 mg open irritation test moderate UCDS** 11/15/1971
skin
rabbit 		10 mg/24 hour open irritation test severe AMIHBC 4,119,1951


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mammal (species unspecified) 		lethal concentration (50 percent kill): 1,800 mg/m3 N/R TPKVAL 14,80,1975
inhalation
mouse 		lowest published lethal concentration: 7,000 ppm/40 minute N/R SCCUR* -,7,1961
inhalation
rat 		lethal concentration (50 percent kill): 4,000 ppm/4 hour N/R IAEC** 17JUN1974
intraperitoneal
rat 		lowest published lethal dose: 50 mg/kg N/R FATOAO 31,238,1968
oral
guinea pig 		lethal dose (50 percent kill): 2,700 mg/kg N/R GISAAA 45(3),79,1980
oral
mouse 		lethal dose (50 percent kill): 2,200 mg/kg N/R GISAAA 45(3),79,1980
oral
rat 		lethal dose (50 percent kill): 111 mg/kg Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Dyspnea

Gastrointestinal: Other changes 		NTIS** OTS0542011
oral
rabbit 		lethal dose (50 percent kill): 3,200 mg/kg Gastrointestinal: Hypermotility, diarrhea

Skin and Appendages: Other: Hair

Nutritional and Gross Metabolic: Body temperature decrease 		GISAAA 45(3),79,1980
skin
rabbit 		lethal dose (50 percent kill): 380 mg/kg N/R IAEC** 17JUN1974
unreported route
mammal (species unspecified) 		lethal dose (50 percent kill): 500 mg/kg N/R TPKVAL 14,80,1975


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 5 ppm DTLVS* TLV/BEI,2002
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 5 ppm;short term exposure limit 10 ppm DTLVS* TLV/BEI,2003
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value short term exposure limit 10 ppm DTLVS* TLV/BEI,2002
TOXICOLOGY REVIEW
CHREAY 9,389,1931


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 5 ppm (12 mg/m3) DTLVS* 3,141,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 5 ppm (12 mg/m3) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 5 ppm (12 mg/m3) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 5 ppm (12 mg/m3) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 5 ppm (12 mg/m3) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 5 ppm (12 mg/m3), short term exposure limit 10 ppm, JAN1993
Occupational Exposure Limit - AUSTRIA MAK 5 ppm (12 mg/m3), JAN1999
Occupational Exposure Limit - BELGIUM time-weighted average 5 ppm (12 mg/m3), short term exposure limit 10 ppm (24 mg/m3), JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 5 ppm (12 mg/m3), JAN1999
Occupational Exposure Limit - FRANCE VME 5 ppm (12 mg/m3), JAN1999
Occupational Exposure Limit - GERMANY MAK 5 ppm (12 mg/m3), JAN1999
Occupational Exposure Limit - NORWAY time-weighted average 5 ppm (12 mg/m3), JAN1999
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 12 mg/m3, 2003
Occupational Exposure Limit - POLAND MAC(time-weighted average) 12 mg/m3, MAC(short term exposure limit) 24 mg/m3, JAN1999
Occupational Exposure Limit - RUSSIA short term exposure limit 1 mg/m3, JAN1993
Occupational Exposure Limit - SWEDEN time-weighted average 5 ppm (12 mg/m3), short term exposure limit 10 ppm (25 mg/m3), JAN1999
Occupational Exposure Limit - SWITZERLAND MAK- week 5 ppm (12 mg/m3), KZG- week 10 ppm (24 mg/m3), JAN1999
Occupational Exposure Limit - TURKEY time-weighted average 5 ppm (12 mg/m3), JAN1993
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

short term exposure limit 10 ppm
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
short term exposure limit 10 ppm


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 40990;
Number of Industries 10;
Total Number of Facilities 808;
Number of Occupations 14;
Total Number of Employees Exposed 13,196
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 40990;
Number of Industries 6;
Total Number of Facilities 235;
Number of Occupations 7;
Total Number of Employees Exposed 8,134;
Total Number of Female Employees Exposed 3,174


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used to produce rubber accelerators, oil-soluble emulsifiers
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NTP Carcinogenesis studies; selected, October 2000


REFERENCES:

CODEN
REFERENCE
AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine. (Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU.
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
CHREAY Chemical Reviews. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) V.1- 1924-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
IAEC** Interagency Collaborative Group on Environmental Carcinogenesis, National Cancer Institute, Memorandum, June 17, 1974
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
SCCUR* Shell Chemical Company. Unpublished Report. (2401 Crow Canyon Rd., San Romon, CA 94583)
TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. (Izdatel'stvo Meditsina, Moscow, USSR) No.1- 1961-
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817)

Used to produce rubber accelerators, oil-soluble emulsifiers

RTECS Compound Description:
   Tumorigen
   Primary Irritant

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