The Registry of Toxic Effects of Chemical Substances

Isopentyl alcohol, nitrite

RTECS #: NT0187500

CAS #: 110-46-3

UPDATE: November 2003 MW: 117.17 MF: C5H11NO2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. ACUTE TOXICITY DATA:
  4. REVIEWS:
  5. NIOSH DOCUMENTATION AND SURVEILLANCE:
  6. STATUS IN FEDERAL AGENCIES:
  7. REFERENCES:

SYNONYMS:

  1. Amyl nitrite
  2. Aspiral
  3. Isoamyl nitrite
  4. Isopentyl nitrite
  5. 3 - Methylbutanol nitrite
  1. 3 - Methylbutyl nitrite
  2. Nitramyl
  3. Nitrous acid, 3 - methylbutyl ester
  4. Vaporole


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis hamster ovary 160 mg/L EMMUEG 10(Suppl 10),1,1987
mutation in microorganisms Salmonella typhimurium 333 µg/plate (+enzymatic activation step) ENMUDM 8(Suppl 7),1,1986
mutation in mammalian somatic cells mouse lymphocyte 3,740 nmol/L EMMUEG 14,115,1989
sister chromatid exchange hamster ovary 16 mg/L EMMUEG 10(Suppl 10),1,1987


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mouse 		lethal concentration (50 percent kill): 1,430 ppm/30 minute Behavioral: Change in motor activity (specific assay) NTOTDY 8,139,1986
inhalation
rat 		lethal concentration (50 percent kill): 716 ppm/4 hour Behavioral: Altered sleep time (including change in righting reflex)

Behavioral: Excitement

Lung, Thorax, or Respiration: Cyanosis 		FAATDF 8,101,1987
intraperitoneal
mouse 		lethal dose (50 percent kill): 130 mg/kg N/R RCOCB8 5,889,1973
intravenous
dog 		lowest published lethal dose: 167 mg/kg Behavioral: Convulsions or effect on seizure threshold RCOCB8 5,889,1973
intravenous
mouse 		lethal dose (50 percent kill): 51 mg/kg N/R RCOCB8 5,889,1973
oral
mouse 		lethal dose (50 percent kill): 852 mg/kg N/R WDZAEK 5,119,1991
oral
rat 		lethal dose (50 percent kill): 505 mg/kg Behavioral: General anesthetic FEPRA7 41,1583,1982
subcutaneous
cat 		lowest published lethal dose: 250 µL/kg N/R YAKUD5 9,759,1967


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
TOXICOLOGY REVIEW
ARPTDI 43,97,2003


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 83996;
Number of Industries 1;
Total Number of Facilities 33;
Number of Occupations 1;
Total Number of Employees Exposed 33


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY


REFERENCES:

CODEN
REFERENCE
ARPTDI Annual Review of Pharmacology and Toxicology. (Annual Reviews, Inc., POB 10139, Palo Alto, CA 94303) V.16- 1976-
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG.
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information, see TOSCF2
FEPRA7 Federation Proceedings, Federation of American Societies for Experimental Biology. (Bethesda, MD) V.1-46, 1942-87.
NTOTDY Neurobehavioral Toxicology and Teratology. (Fayetteville, NY) V.3-8, 1981-86. For publisher information, see NETEEC.
RCOCB8 Research Communications in Chemical Pathology and Pharmacology. (PJD Pub. Ltd., P.O. Box 966, Westbury, NY 11590) V.1- 1970-
WDZAEK Weisheng Dulixue Zazhi. Journal of Health Toxicology. (Weisheng Dulixue Zazhi Bianjibu, Dongdaqiao, Chaoyang Menwai, Beijing, Peop. Rep. China) V.1- 1987
YAKUD5 Gekkan Yakuji. Pharmaceuticals Monthly. (Yakugyo Jihosha, Inaoka Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan) V.1- 1959-

RTECS Compound Description:
   Mutagen

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