The Registry of Toxic Effects of Chemical Substances

Isophthalonitrile, tetrachloro -

RTECS #: NT2600000

CAS #: 1897-45-6

UPDATE: May 2005 MW: 265.90 MF: C8Cl4N2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. TUMORIGENIC DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. REVIEWS:
  8. STANDARDS AND REGULATIONS:
  9. NIOSH DOCUMENTATION AND SURVEILLANCE:
  10. STATUS IN FEDERAL AGENCIES:
  11. REFERENCES:

SYNONYMS:

  1. 1,3 - Benzenedicarbonitrile, 2,4,5,6 - tetrachloro -
  2. 1,3 - Dicyanotetrachlorobenzene
  3. 2,4,5,6 - Tetrachloro - 1,3 - benzenedicarbonitrile
  4. 2,4,5,6 - Tetrachloro - 1,3 - dicyanobenzene
  5. 2,4,5,6 - Tetrachloro - 3 - cyanobenzonitrile
  6. Bravo
  7. Bravo 6F
  8. Bravo - W - 75
  9. Chloroalonil
  10. Chlorothalonil
  11. Chlorthalonil (German)
  12. Clortocaf ramato
  13. Clortosip
  14. DAC 2787
  15. Daconil
  16. Daconil 2787
  17. Daconil 2787 flowable fungicide
  18. Dacosoil
  1. Exotherm
  2. Exotherm termil
  3. Forturf
  4. Isophthalonitrile, 2,4,5,6 - tetrachloro -
  5. NCI - C00102
  6. Nopcocide
  7. Nopcocide N - 96
  8. Nopcocide N40D & N96
  9. Sweep
  10. TCIN
  11. TPN (pesticide)
  12. Termil
  13. Tetrachlorisoftalonitril (Czech)
  14. Tetrachloroisophthalonitrile
  15. Vanox
  16. m - TCPN
  17. m - Tetrachlorophthalonitrile
  18. meta - Tetrachlorophthalodinitrile


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis hamster ovary 500 µg/L EMMUEG 10(Suppl 10),1,1987
DNA damage hamster ovary 200 nmol/L MUREAV 419,79,1998
DNA damage human lymphocyte 50 µmol/L MUREAV 375,205,1997
mutation in microorganisms Aspergillus nidulans 800 µg/L (-enzymatic activation step) MUREAV 176,29,1987
mutation in microorganisms Salmonella typhimurium 1 mg/plate (+enzymatic activation step) EMCAE8 5,11,1985
micronucleus test unreported route
other fish 		1,400 ppt/7 day- continuous HYHPDO 12,153,1987
mutation in mammalian somatic cells mouse lymphocyte 120 µg/L EMMUEG 12,85,1988
other mutation test systems Escherichia coli 14,690 nmol/L EMMUEG 19,98,1992
sister chromatid exchange hamster ovary 2 mg/L EMMUEG 10(Suppl 10),1,1987


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 1.2 gm/kg (1-6 day pregnant) Reproductive: Specific developmental abnormalities: Urogenital system VHTODE 42,361,2000


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 142 gm/kg/80 week- continuous Tumorigenic: Carcinogenic by RTECS criteria

Kidney, Ureter, and Bladder: Kidney tumors 		NCITR* NCI-TR-41,1978


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lethal concentration (50 percent kill): 310 mg/m3/1 hour N/R FMCHA2 -,C72,1991
intraperitoneal
mouse 		lethal dose (50 percent kill): 2,500 µg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Muscle contraction or spasticity 		INHEAO 4,11,1966
oral
dog 		lethal dose (50 percent kill): >5 gm/kg N/R 85JFAN A090,1984
oral
mouse 		lethal dose (50 percent kill): 3,700 mg/kg N/R HOEKAN 30,53,1980
oral
rat 		lethal dose (50 percent kill): 10 gm/kg N/R 85ARAE 4,75,1976/1977
skin
rat 		lethal dose (50 percent kill): >2,500 mg/kg N/R FAATDF 7,299,1986
skin
rabbit 		lethal dose (50 percent kill): >10 gm/kg N/R PEMNDP 9,159,1991


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 6,750 mg/kg/90 day- continuous Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Kidney, Ureter, and Bladder: Changes in bladder weight 		TOLED5 53,155,1990
oral
rat 		lowest published toxic dose: 72,240 mg/kg/129 week- continuous Kidney, Ureter, and Bladder: Kidney tumors HBPTO* 1,814,2001


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
International Agency for Research on Cancer (IARC) Cancer Review Animal Limited Evidence IMEMDT 30,319,1983
International Agency for Research on Cancer (IARC) Cancer Review Animal Sufficient Evidence IMEMDT 73,183,1999
International Agency for Research on Cancer (IARC) Cancer Review Human No Adequate Data IMEMDT 30,319,1983
International Agency for Research on Cancer (IARC) Cancer Review Human Inadequate Evidence IMEMDT 73,183,1999
International Agency for Research on Cancer (IARC) Cancer Review Group 2B IMEMDT 73,183,1999
TOXICOLOGY REVIEW
TOLED5 127,29,2002
TOXICOLOGY REVIEW
MUREAV 562,77,2004
TOXICOLOGY REVIEW
MUREAV 567,227,2004


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Supported RBREV* -,99,1998
Occupational Exposure Limit - AUSTRIA Suspected Carcinogen, JAN1999


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: T1833;
Number of Industries 21;
Total Number of Facilities 3,268;
Number of Occupations 26;
Total Number of Employees Exposed 62,724;
Total Number of Female Employees Exposed 6,716


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Positive/limited: Carcinogenicity-mouse/rat
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as fungicide for use in coating, caulk, wood preservative and anti-fouling systems
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Bioassay (feed);clear evidence:rat NCITR* NCI-TR-41,1978
NCI Carcinogenesis Bioassay (feed);no evidence:mouse NCITR* NCI-TR-41,1978


REFERENCES:

CODEN
REFERENCE
85ARAE "Agricultural Chemicals," Thomson, W.T., 4 vols., Fresno, CA, Thomson Publications, 1976/77 revision
85JFAN "Agrochemicals Handbook," with updates, Hartley, D., and H. Kidd, eds., Nottingham, Royal Soc. of Chemistry, 1983-86
EMCAE8 Environmental Mutagens and Carcinogens. (Korean Environmental Mutagen Soc., c/o Dept. of Zoology, Seoul National Univ., Seoul 151, S. Korea) V.1- 1981-
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information, see TOSCF2
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
FMCHA2 Farm Chemicals Handbook. (Meister Pub., 37841 Euclid Ave., Willoughy, OH 44094)
HBPTO* Handbook of pesticide toxicology. Robert Krieger ed, Academic press, 2001
HOEKAN Hokkaidoritsu Eisei Kenkyushoho. Report of the Hokkaido Institute of Public Health. (Nishi- 12-chome, Kita-19-jo, Kita-ku, Sapporo 060, Japan) No.1- 1951-
HYHPDO Hunan Yixueyuan Xuebao. Journal of Hunan Medical College. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) Beginning history not known.
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
INHEAO Industrial Health. (National Institute of Industrial Health, 6-21-1 Nagao, Tama-ku, Kawasaki, 213 Japan) V.1- 1963-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NCITR* National Cancer Institute Carcinogenesis Technical Report Series. (Bethesda, MD) No.0-205. For publisher information, see NTPTR*.
PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4 7QG, UK) V.1- 1968-
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
VHTODE Veterinary and Human Toxicology. (American College of Veterinary and Comparative Toxicology, Publication Office, Comparative Toxicology, Manhattan, KS 66506) V.19- 1977-

Used as fungicide for use in coating, caulk, wood preservative and anti-fouling systems

RTECS Compound Description:
   Agricultural Chemical
   Tumorigen
   Mutagen
   Reproductive Effector

ALT CAS #: 37223-69-1
ALT CAS #: 101963-73-9
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