The Registry of Toxic Effects of Chemical Substances

Isocyanic acid, methyl ester

RTECS #: NQ9450000

CAS #: 624-83-9

UPDATE: November 2004 MW: 57.06 MF: C2H3NO


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. REPRODUCTIVE EFFECTS DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. REVIEWS:
  8. STANDARDS AND REGULATIONS:
  9. NIOSH DOCUMENTATION AND SURVEILLANCE:
  10. STATUS IN FEDERAL AGENCIES:
  11. REFERENCES:

SYNONYMS:

  1. Iso - cyanatomethane
  2. Isocyanate de methyle (French)
  3. Methyl isocyanat (German)
  4. Methyl isocyanate
  5. Methyl isocyanate (ACGIH:OSHA)
  1. Methylisocyanaat (Dutch)
  2. Methylisokyanat (Czech)
  3. Metil isocianato (Italian)
  4. RCRA waste number P064
  5. TL 1450


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		5 µL/24 hour severe NTIS** OTS0529151
skin
rabbit 		10 µL/24 hour moderate NTIS** OTS0529151


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis hamster ovary 10,100 µg/L ENMUDM 9,19,1987
cytogenetic analysis inhalation
mouse 		3 ppm/6 hour/4 day- continuous ENMUDM 9,37,1987
mutation in microorganisms Salmonella typhimurium 50 µg/plate (+enzymatic activation step) IJEBA6 25,548,1987
mutation in microorganisms Salmonella typhimurium 100 µg/plate (-enzymatic activation step) MUREAV 204,123,1988
micronucleus test inhalation
mouse 		6 ppm/6 hour/4 day- continuous ENMUDM 9,37,1987
mutation in mammalian somatic cells mouse lymphocyte 8 µmol/L MUREAV 174,285,1986
other mutation test systems Escherichia coli 1 µmol/plate MUREAV 283,97,1992
other mutation test systems inhalation
mouse 		3 ppm/6 hour/4 day- continuous ENMUDM 9,29,1987
sister chromatid exchange hamster ovary 900 µg/L ENMUDM 9,19,1987
sister chromatid exchange inhalation
mouse 		1 ppm/6 hour/4 day- continuous ENMUDM 9,29,1987


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mouse 		lowest published toxic concentration: 9 ppm/3 hour (8 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) 		JTEHD6 30,1,1990
inhalation
mouse 		lowest published toxic concentration: 9 ppm/3 hour (8 day pregnant) Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Effects on embryo or fetus: Extra embryonic structures (e.g., placenta, umbilical cord)

Reproductive: Specific developmental abnormalities: Musculoskeletal system 		JTEHD6 21,265,1987
inhalation
mouse 		lowest published toxic concentration: 9 ppm/3 hour (1 day pregnant) Reproductive: Other effects on male

Reproductive: Effects on fertility: Mating performance (e.g., # sperm positive females per # females mated; # copulations per # estrus cycles) 		JTEHD6 21,265,1987
inhalation
mouse 		lowest published toxic concentration: 1 ppm/6 hour (14-17 day pregnant) Reproductive: Effects on newborn: Stillbirth EVHPAZ 72,149,1987
inhalation
mouse 		lowest published toxic concentration: 3 ppm/6 hour (14-17 day pregnant) Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive)

Reproductive: Effects on newborn: Weaning or lactation index (e.g., # alive at weaning per # alive at day 4) 		EVHPAZ 72,149,1987
inhalation
rat 		lowest published toxic concentration: 9 ppm/3 hour (10 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) 		JTEHD6 30,1,1990


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
guinea pig 		lethal concentration (50 percent kill): 5,400 ppb/6 hour Eye: Lacrimation

Lung, Thorax, or Respiration: Dyspnea 		FAATDF 6,747,1986
inhalation
human 		lowest published toxic concentration: 2 ppm Olfaction: Other olfaction effects

Eye: Conjunctiva irritation

Lung, Thorax, or Respiration: Other changes 		ATXKA8 20,235,1964
inhalation
mouse 		lethal concentration (50 percent kill): 12,200 ppb/6 hour Eye: Lacrimation

Lung, Thorax, or Respiration: Dyspnea 		FAATDF 6,747,1986
inhalation
rat 		lethal concentration (50 percent kill): 6,100 ppb/6 hour Eye: Lacrimation

Lung, Thorax, or Respiration: Dyspnea 		FAATDF 6,747,1986
oral
mouse 		lethal dose (50 percent kill): 120 mg/kg N/R TXAPA9 42,417,1977
oral
rat 		lethal dose (50 percent kill): 51,500 µg/kg Peripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage)

Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Respiratory depression 		IJEBA6 25,531,1987
subcutaneous
mouse 		lethal dose (50 percent kill): 81,900 µg/kg Peripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage)

Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Respiratory depression 		IJEBA6 25,531,1987
subcutaneous
rat 		lethal dose (50 percent kill): 261 mg/kg Peripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage)

Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Respiratory depression 		IJEBA6 25,531,1987
subcutaneous
rabbit 		lethal dose (50 percent kill): 126 mg/kg N/R TXCYAC 51,223,1988
skin
mouse 		lethal dose (50 percent kill): 1,820 mg/kg N/R YKYUA6 38,391,1987
skin
rat 		lethal dose (50 percent kill): 2,780 mg/kg N/R YKYUA6 38,391,1987
skin
rabbit 		lethal dose (50 percent kill): 220 µL/kg Skin: After systemic exposure: Dermatitis, other NTIS** OTS0529151


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mouse 		lowest published toxic concentration: 3 ppm/6 hour/4 day- intermittent Olfaction: Other olfaction effects

Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		FAATDF 9,480,1987
inhalation
rat 		lowest published toxic concentration: 3 ppm/6 hour/4 day- intermittent Lung, Thorax, or Respiration: Fibrosis, focal (pneumoconiosis)

Endocrine: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		FAATDF 9,480,1987
inhalation
rat 		lowest published toxic concentration: 3 ppm/6 hour/8 day- intermittent Lung, Thorax, or Respiration: Changes in lung weight

Blood: Pigmented or nucleated red blood cells

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		EVHPAZ 72,117,1987
inhalation
rat 		lowest published toxic concentration: 3,070 ppb/6 hour/8 day- intermittent Behavioral: Food intake (animal)

Liver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		NTIS** OTS0535177


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.02 ppm (skin) DTLVS* TLV/BEI,2003


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 0.02 ppm (0.05 mg/m3) (skin) DTLVS* 3,167,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 0.02 ppm (0.05 mg/m3) (skin) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 0.02 ppm (0.05 mg/m3) (skin) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 0.02 ppm (0.05 mg/m3) (skin) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 0.02 ppm (0.05 mg/m3) (skin) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRIA MAK 0.01 ppm (0.025 mg/m3), JAN1999
Occupational Exposure Limit - BELGIUM time-weighted average 0.02 ppm (0.047 mg/m3), Skin, JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 0.01 ppm (0.03 mg/m3), Skin, JAN1999
Occupational Exposure Limit - FRANCE VME 0.02 ppm (0.05 mg/m3), Skin, JAN1999
Occupational Exposure Limit - GERMANY MAK 0.01 ppm (0.025 mg/m3), JAN1999
Occupational Exposure Limit - HUNGARY time-weighted average 0.05 mg/m3, short term exposure limit 0.06 mg/m3, Skin, JAN1993
Occupational Exposure Limit - NORWAY time-weighted average 0.005 ppm (0.015 mg/m3), JAN1999
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 0.05 mg/m3, Skin, 2003
Occupational Exposure Limit - RUSSIA short term exposure limit 0.05 mg/m3, Skin, JAN1993
Occupational Exposure Limit - SWEDEN time-weighted average 0.005 ppm, CEILING 0.01 ppm, JAN1999
Occupational Exposure Limit - SWITZERLAND MAK- week 0.01 ppm (0.025 mg/m3), KZG- week 0.02 ppm (0.05 mg/m3), JAN1999
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 0.02 mg(NCO)/m3, short term exposure limit 0.07 mg(NCO)/m3, SEP2000
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 0.02 ppm (skin)
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 0.02 ppm (skin)


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO METHYL ISOCYANATE-air 10 hour time-weighted average 0.02 ppm (Sk) NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 47625;
Number of Industries 2;
Total Number of Facilities 56;
Number of Occupations 3;
Total Number of Employees Exposed 2,381
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 47625;
Number of Industries 1;
Total Number of Facilities 7;
Number of Occupations 1;
Total Number of Employees Exposed 1,822;
Total Number of Female Employees Exposed 272


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used in carbamate pesticides and as chemical intermediate
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
OSHA ANALYTICAL METHOD #54


REFERENCES:

CODEN
REFERENCE
ATXKA8 Archiv fuer Toxikologie. (Berlin, Fed. Rep. Ger.) V.15-31, 1954-74. For publisher information, see ARTODN.
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG.
EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing Office, Supt of Documents, Washington, DC 20402) No.1- 1972-
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information, see TOSCF2
IJEBA6 Indian Journal of Experimental Biology. (Publications & Information Directorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973-
YKYUA6 Yakkyoku. Pharmacy. (Nanzando, 4-1-11, Yushima, Bunkyo-ku, Tokyo, Japan) V.1- 1950-

Used in carbamate pesticides and as chemical intermediate

NIOSH PROFILE (ISOCYANATES, ORGANIC), SRC, 10/77

RTECS Compound Description:
   Mutagen
   Reproductive Effector
   Human Data
   Primary Irritant

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