RTECS:NP9625000 The Registry of Toxic Effects of Chemical Substances | CDC/NIOSH

The Registry of Toxic Effects of Chemical Substances

Isobutyl alcohol

RTECS #: NP9625000

CAS #: 78-83-1

UPDATE: November 2004 MW: 74.14 MF: C₄H₁₀O

NOTE:

TOXICITY DATA HAVE NOT BEEN EVALUATED. OMISSION OF A SUBSTANCE OR NOTATION DOES NOT IMPLY ANY RELIEF FROM REGULATORY RESPONSIBILITY.

TABLE OF CONTENTS:

SYNONYMS:

MUTATION DATA:

TUMORIGENIC DATA:

ACUTE TOXICITY DATA:

OTHER MULTIPLE DOSE DATA:

REVIEWS:

STANDARDS AND REGULATIONS:

NIOSH DOCUMENTATION AND SURVEILLANCE:

STATUS IN FEDERAL AGENCIES:

REFERENCES:

SYNONYMS:

Alcool isobutylique (French)

Fermentation butyl alcohol

1 - Hydroxymethylpropane

Isobutanol

Isobutyl alcohol (ACGIH:OSHA)

Isobutylalkohol (Czech)

Isopropylcarbinol

2 - Methyl - 1 - propanol

2 - Methylpropan - 1 - ol

2 - Methyl propanol

2 - Methylpropyl alcohol

1 - Propanol, 2 - methyl -

RCRA waste number U140

SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

MUTATION DATA AND REFERENCES:
SYSTEM TEST ROUTE/
ORGANISM/
TISSUE DOSE REFERENCE
mutation in microorganisms Escherichia coli 25,000 ppm (-enzymatic activation step) ABMGAJ 23,843,1969

REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

TUMORIGENIC DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
oral
rat lowest published toxic dose: 29 gm/kg/71 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Skin and Appendages: Tumors

Blood: Leukemia ARGEAR 45,19,1975
subcutaneous
rat lowest published toxic dose: 9 gm/kg/78 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Gastrointestinal: Tumors

Liver: Tumors ARGEAR 45,19,1975

ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
eye
human lowest published toxic dose: 72.5 mg/m³ Eye: Conjunctiva irritation VCVGK* -,103,1984
inhalation
guinea pig lethal concentration (50 percent kill): 19,900 mg/m³/4 hour N/R VCVGK* -,102,1984
inhalation
mammal (species unspecified) lowest published toxic concentration: 15.7 mg/m³/4 hour Brain and Coverings: Other degenerative changes

Liver: Multiple effects

Endocrine: Evidence of thyroid hyperfunction VCVGK* -,102,1984
inhalation
mouse lethal concentration (50 percent kill): 15,500 mg/m³/2 hour N/R VCVGK* -,102,1984
inhalation
mouse lowest published toxic concentration: 700 ppm/6 minute Lung, Thorax, or Respiration: Respiratory depression TOLED5 9,137,1981
inhalation
rat lowest published lethal concentration: 8,000 ppm/4 hour N/R AMIHBC 10,61,1954
inhalation
rat lethal concentration (50 percent kill): 19,200 mg/m³/4 hour N/R VCVGK* -,102,1984
inhalation
rat lowest published lethal concentration: 8,000 mg/m³/4 hour N/R VCVGK* -,102,1984
inhalation
rabbit lethal concentration (50 percent kill): 2,630 mg/m³/4 hour N/R VCVGK* -,102,1984
intraperitoneal
guinea pig lethal dose (50 percent kill): 1,201 mg/kg N/R EVHPAZ 61,321,1985
intraperitoneal
hamster lethal dose (50 percent kill): 1,401 mg/kg N/R EVHPAZ 61,321,1985
intraperitoneal
mouse lethal dose (50 percent kill): 544 mg/kg Liver: Other changes RCOCB8 26,75,1979
intraperitoneal
mouse lethal dose (50 percent kill): 544 mg/kg N/R VCVGK* -,102,1984
intraperitoneal
rat lethal dose (50 percent kill): 720 mg/kg N/R EVHPAZ 61,321,1985
intraperitoneal
rabbit lethal dose (50 percent kill): 323 mg/kg N/R EVHPAZ 61,321,1985
intravenous
cat lowest published lethal dose: 180 mg/kg N/R VCVGK* -,102,1984
intravenous
mouse lethal dose (50 percent kill): 417 mg/kg N/R EVHPAZ 61,321,1985
intravenous
rat lethal dose (50 percent kill): 340 mg/kg N/R EVHPAZ 61,321,1985
oral
human lowest published lethal dose: 428 mg/kg N/R VCVGK* -,103,1984
oral
mouse lethal dose (50 percent kill): 3,500 mg/kg N/R VCVGK* -,102,1984
oral
rat lethal dose (50 percent kill): 2,460 mg/kg N/R AMIHBC 10,61,1954
oral
rabbit lowest published lethal dose: 3,750 mg/kg Behavioral: General anesthetic JLCMAK 10,985,1925
oral
rabbit lethal dose (50 percent kill): 74.1 mg/kg N/R VCVGK* -,102,1984
oral
rabbit lowest published lethal dose: 3,750 mg/kg N/R VCVGK* -,102,1984
skin
rabbit lethal dose (50 percent kill): 3,400 mg/kg N/R NPIRI* 1,11,1974

OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
inhalation
rat lowest published toxic concentration: 1,500 ppm/6 hour/2 week- intermittent Brain and Coverings: Other degenerative changes

Lung, Thorax, or Respiration: Dyspnea NTIS** OTS0558856
inhalation
rat lowest published toxic concentration: 0.5 mg/m³/122 day- continuous Lung, Thorax, or Respiration: Other changes

Liver: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain VCVGK* -,103,1994
oral
rat lowest published toxic dose: 93 gm/kg/13 week- intermittent Behavioral: Somnolence (general depressed activity)

Nutritional and Gross Metabolic: Changes in: K

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field NTIS OTS0531063

REVIEWS:
ORGANIZATION STANDARD
REFERENCE**

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 50 ppm DTLVS* TLV/BEI,2003

STANDARDS AND REGULATIONS:
ORGANIZATION STANDARD
REFERENCE

Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 100 ppm (300 mg/m³) DTLVS* 3,140,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 100 ppm (300 mg/m³) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 100 ppm (300 mg/m³) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 100 ppm (300 mg/m³) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 100 ppm (300 mg/m³) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 50 ppm (150 mg/m³), JAN1993
Occupational Exposure Limit - AUSTRIA MAK 50 ppm (150 mg/m³), JAN1999
Occupational Exposure Limit - BELGIUM time-weighted average 50 ppm (152 mg/m³), JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 50 ppm (150 mg/m³), Skin, JAN1999
Occupational Exposure Limit - FRANCE VME 50 ppm (150 mg/m³), JAN1999
Occupational Exposure Limit - GERMANY MAK 100 ppm (300 mg/m³), JAN1999
Occupational Exposure Limit - JAPAN Occupational Exposure Limit 50 ppm (150 mg/m³), JAN1999
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 150 mg/m³, 2003
Occupational Exposure Limit - POLAND MAC(time-weighted average) 100 mg/m³, MAC(short term exposure limit) 200 mg/m³, JAN1999
Occupational Exposure Limit - RUSSIA time-weighted average 50 ppm, short term exposure limit 10 mg/m³, Skin, JAN1993
Occupational Exposure Limit - SWITZERLAND MAK- week 50 ppm (150 mg/m³), KZG- week 100 ppm (300 mg/m³),JAN1999
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 50 ppm (154 mg/m³), short term exposure limit 75 ppm, SEP2000
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 50 ppm
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 50 ppm

NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO ISOBUTYL ALCOHOL-air 10 hour time-weighted average 50 ppm NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 40430;
Number of Industries 181;
Total Number of Facilities 16,985;
Number of Occupations 98;
Total Number of Employees Exposed 107,310
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 40430;
Number of Industries 155;
Total Number of Facilities 15,449;
Number of Occupations 99;
Total Number of Employees Exposed 256,975;
Total Number of Female Employees Exposed 49,376

STATUS IN FEDERAL AGENCIES:
ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Alcohols II, 1401

REFERENCES:
CODEN
REFERENCE

ABMGAJ Acta Biologica et Medica Germanica. (Berlin, Ger. Dem. Rep.) V.1-41, 1958-82. For publisher information, see BBIADT.
AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine. (Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU.
ARGEAR Archiv fuer Geschwulstforschung. (VEB Verlag Volk und Gesundheit Neue Gruenstr. 18, Berlin DDR-1020, Ger. Dem. Rep.) V.1- 1949-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing Office, Supt of Documents, Washington, DC 20402) No.1- 1972-
JLCMAK Journal of Laboratory and Clinical Medicine. (C.V. Mosby Co., 11830 Westline Industrial Dr., St. Louis, MO 63141) V.1- 1915-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NPIRI* Raw Material Data Handbook, Vol.1: Organic Solvents, 1974. (National Assoc. of Printing Ink Research Institute, Francis McDonald Sinclair Memorial Laboratory, Lehigh Univ., Bethlehem, PA 18015)
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
RCOCB8 Research Communications in Chemical Pathology and Pharmacology. (PJD Pub. Ltd., P.O. Box 966, Westbury, NY 11590) V.1- 1970-
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
VCVGK* "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994.

NIOSH PROFILE (ALCOHOLS), SRI, 2/77

RTECS Compound Description:
   Tumorigen
   Mutagen
   Human Data

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