The Registry of Toxic Effects of Chemical Substances

Iron, tris (dimethyldithiocarbamato) -

RTECS #: NO8750000

CAS #: 14484-64-1

UPDATE: November 2004 MW: 416.51 MF: C9H18N3S6•Fe


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. TUMORIGENIC DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. REVIEWS:
  8. STANDARDS AND REGULATIONS:
  9. NIOSH DOCUMENTATION AND SURVEILLANCE:
  10. STATUS IN FEDERAL AGENCIES:
  11. REFERENCES:

SYNONYMS:

  1. Aafertis
  2. Bercema fertam 50
  3. Carbamic acid, dimethyldithio - , iron salt
  4. Carbamodithioic acid, dimethyl - , iron complex
  5. Dimethylcarbamodithioic acid, iron complex
  6. Dimethylcarbamodithioic acid, iron (3+) salt
  7. Dimethyldithiocarbamic acid, iron salt
  8. Dimethyldithiocarbamic acid, iron (3+) salt
  9. ENT 14,689
  10. Eisen (III) - tris (N,N - dimethyldithiocarbamat) (German)
  11. Eisendimethyldithiocarbamat (German)
  12. Ferbam
  13. Ferbam (ACGIH:OSHA)
  14. Ferbam 50
  15. Ferberk
  1. Fermate
  2. Ferradow
  3. Ferric dimethyldithiocarbamate
  4. Fuklasin Ultra
  5. Fuklazin
  6. Hexaferb
  7. Iron dimethyldithiocarbamate
  8. Iron, tris (dimethylcarbamodithioato - S,S') - , (OC - 6 - 11) -
  9. Karbam Black
  10. Liromate
  11. Stauffer ferbam
  12. Trimanzone
  13. Tris (N,N - dimethyldithiocarbamato) iron (111)
  14. Tris (dimethyldithiocarbamato) iron
  15. Vancide FE95


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis oral
mouse 		30 mg/kg TCMUD8 22,451,2002
DNA repair Bacillus subtilis 2 µg/disc MUREAV 40,19,1976
mutation in microorganisms other microorganisms 1,000 ppm (-enzymatic activation step) MMAPAP 50,233,1973
mutation in microorganisms Salmonella typhimurium 50 µg/plate (+enzymatic activation step) CSHCAL 4,267,1977
mutation in microorganisms Salmonella typhimurium 200 µg/plate (-enzymatic activation step) MBENDX 14,377,1986
sperm morphology oral
mouse 		5 gm/kg/5 day- continuous MUREAV 224,405,1989


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lowest published toxic dose: 5 gm/kg (5 day male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) MUREAV 224,405,1989
oral
rat 		lowest published toxic dose: 1,140 mg/kg (6-15 day pregnant) Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) 		TXAPA9 35,83,1976
oral
rat 		lowest published toxic dose: 536 mg/kg (16-22 day pregnant/21 day after birth) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) TXAPA9 35,83,1976
oral
rat 		lowest published toxic dose: 3,479 mg/kg (16-22 day pregnant/21 day after birth) Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive)

Reproductive: Effects on newborn: Weaning or lactation index (e.g., # alive at weaning per # alive at day 4) 		TXAPA9 35,83,1976
subcutaneous
mouse 		lowest published toxic dose: 41,760 µg/kg (6-14 day pregnant) Reproductive: Effects on embryo or fetus: Extra embryonic structures (e.g., placenta, umbilical cord)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Effects on embryo or fetus: Fetal death 		NTIS** PB223-160


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lowest published toxic dose: 3,500 mg/kg/78 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Liver: Tumors 		NTIS** PB223-159
subcutaneous
mouse 		lowest published toxic dose: 100 mg/kg Tumorigenic: Carcinogenic by RTECS criteria

Blood: Tumors 		NTIS** PB223-159


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
guinea pig 		lowest published lethal dose: 2,300 mg/kg N/R JAPMA8 41,662,1952
intraperitoneal
mouse 		lethal dose (50 percent kill): 3 gm/kg N/R JAPMA8 41,662,1952
intraperitoneal
rat 		lethal dose (50 percent kill): 2,700 mg/kg N/R JAPMA8 41,662,1952
intraperitoneal
rabbit 		lowest published lethal dose: 1,500 mg/kg N/R JAPMA8 41,662,1952
oral
guinea pig 		lowest published lethal dose: 2 gm/kg N/R JAPMA8 41,662,1952
oral
mouse 		lethal dose (50 percent kill): 3,400 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Excitement

Behavioral: Ataxia 		JTEHD6 4,93,1978
oral
rat 		lethal dose (50 percent kill): 1,130 mg/kg N/R FATOAO 32,356,1969
oral
rabbit 		lowest published lethal dose: 3 gm/kg N/R JAPMA8 41,662,1952


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
dog 		lowest published toxic dose: 9,125 mg/kg/1 year- continuous Behavioral: Convulsions or effect on seizure threshold

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		JPETAB 118,174,1956
oral
rat 		lowest published toxic dose: 45 gm/kg/30 day- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		JAPMA8 41,662,1952
oral
rat 		lowest published toxic dose: 91,250 mg/kg/2 year- continuous Brain and Coverings: Other degenerative changes

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		JPETAB 118,174,1956


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 10 mg/m3 DTLVS* TLV/BEI,2003
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Not Classifiable as a Human Carcinogen DTLVS* TLV/BEI,2003
International Agency for Research on Cancer (IARC) Cancer Review Animal Inadequate Evidence IMEMDT 12,121,1976
International Agency for Research on Cancer (IARC) Cancer Review Human No Adequate Data IMEMDT 12,121,1976
International Agency for Research on Cancer (IARC) Cancer Review Group 3 IMSUDL 7,56,1987


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Supported RBREV* -,173,1998
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 10 mg/m3 DTLVS* 3,113,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 15 mg/m3, total dust CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 15 mg/m3, total dust CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 15 mg/m3, total dust CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 15 mg/m3 CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 10 mg/m3, JAN1993
Occupational Exposure Limit - AUSTRIA MAK 10 mg/m3, JAN1999
Occupational Exposure Limit - BELGIUM time-weighted average 10 mg/m3, JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 5 mg/m3, JAN1999
Occupational Exposure Limit - FRANCE VME 10 mg/m3, JAN1999
Occupational Exposure Limit - GERMANY MAK 15 mg/m3, JAN1999
Occupational Exposure Limit - NORWAY time-weighted average 1 mg(Fe)/m3, JAN1999
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 10 mg/m3, 2003
Occupational Exposure Limit - SWITZERLAND MAK- week 10 mg/m3, JAN1999
Occupational Exposure Limit - TURKEY time-weighted average 15 mg/m3, JAN1993
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 10 mg/m3, short term exposure limit 20 mg/m3, SEP2000
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Not Classifiable as a Human Carcinogen
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Not Classifiable as a Human Carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO FERBAM-air 10 hour time-weighted average 10 mg/m3 NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: M0362;
Number of Industries 1;
Total Number of Facilities 12;
Number of Occupations 1;
Total Number of Employees Exposed 72
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: M0362;
Number of Industries 1;
Total Number of Facilities 291;
Number of Occupations 1;
Total Number of Employees Exposed 3,205


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Inconclusive: B subtilis rec assay
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as a fungicide, rubber accelerator and plastics pro-degradant
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
CSHCAL Cold Spring Harbor Conferences on Cell Proliferation. (Cold Spring Harbor, NY) V.1-10, 1974-83.
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939-
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979-
JAPMA8 Journal of the American Pharmaceutical Association, Scientific Edition. (Washington, DC) V.29-49, 1940-60. For publisher information, see JPMSAE.
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76-
MBENDX Medecine, Biologie, Environnement. (Institut Europeen d'Ecologie et de Cancerologie, Rue des Fripiers, 24 bis, 1000 Brussels, Belgium) V.1- 1973-
MMAPAP Mycopathologia et Mycologia Applicata. (The Hague, Netherlands) V.5-54(4), 1950-74. For publisher information, see MYCPAH.
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
TCMUD8 Teratogenesis, Carcinogenesis, and Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1980-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-

Used as a fungicide, rubber accelerator and plastics pro-degradant

RTECS Compound Description:
   Agricultural Chemical
   Tumorigen
   Mutagen
   Reproductive Effector

ALT CAS #: 301-05-3
ALT CAS #: 13494-27-4
ALT CAS #: 64070-92-4
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