The Registry of Toxic Effects of Chemical Substances

Iron carbonyl

RTECS #: NO4900000

CAS #: 13463-40-6

UPDATE: November 2004 MW: 195.90 MF: C5FeO5


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. ACUTE TOXICITY DATA:
  3. OTHER MULTIPLE DOSE DATA:
  4. REVIEWS:
  5. STANDARDS AND REGULATIONS:
  6. NIOSH DOCUMENTATION AND SURVEILLANCE:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. FER pentacarbonyle (French)
  2. Iron carbonyl (Fe (CO) 5) , (TB - 5 - 11) (9CI)
  3. Iron pentacarbonyl
  1. Iron pentacarbonyl (ACGIH)
  2. Iron, pentacarbonyl -
  3. Pentacarbonyliron


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
guinea pig 		lowest published lethal concentration: 140 ppm/30 minute N/R EPASR* 8EHQ-0591-1177
inhalation
mouse 		lethal concentration (50 percent kill): 2,190 mg/m3/30 minute N/R AMIHAB 19,11,1959
inhalation
rat 		lethal concentration (50 percent kill): 10 ppm/4 hour Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Dyspnea

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		NTIS** OTS0535889
inhalation
rabbit 		lowest published lethal concentration: 250 ppm/45 minute N/R 34ZIAG -,335,1969
intraperitoneal
mouse 		lethal dose (50 percent kill): 60 mg/kg N/R EPASR* 8EHQ-0591-1177
intravenous
rabbit 		lethal dose (50 percent kill): 11 mg/kg N/R JIHTAB 25,415,1943
oral
cat 		lethal dose (50 percent kill): 100 mg/kg N/R EPASR* 8EHQ-0591-1177
oral
guinea pig 		lethal dose (50 percent kill): 22 mg/kg N/R JIHTAB 25,415,1943
oral
mouse 		lethal dose (50 percent kill): 62 mg/kg N/R GTPZAB 26(6),52,1982
oral
rat 		lethal dose (50 percent kill): 25 mg/kg N/R EPASR* 8EHQ-0591-1177
oral
rabbit 		lethal dose (50 percent kill): 12 mg/kg N/R JIHTAB 25,415,1943
subcutaneous
rabbit 		lethal dose (50 percent kill): 240 mg/kg N/R JIHTAB 25,415,1943
skin
rabbit 		lethal dose (50 percent kill): 56 mg/kg Lung, Thorax, or Respiration: Dyspnea

Lung, Thorax, or Respiration: Cyanosis

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		NTIS** OTS0535885


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published toxic concentration: 15 ppm/6 hour/2 day- intermittent Lung, Thorax, or Respiration: Chronic pulmonary edema or congestion

Lung, Thorax, or Respiration: Cyanosis

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		BJIMAG 27,1,1970
oral
rat 		lowest published toxic dose: 157.5 gm/kg/6 week- continuous Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Nutritional and Gross Metabolic: Changes in: Fe 		TOLED5 133,193,2002


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.1 (Fe)ppm DTLVS* TLV/BEI,2002
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.1 ppm;short term exposure limit 0.2 ppm DTLVS* TLV/BEI,2003
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value short term exposure limit 0.2 (Fe)ppm DTLVS* TLV/BEI,2002
TOXICOLOGY REVIEW
AEHLAU 23,373,1971


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 0.01 ppm (0.08 mg/m3) DTLVS* 3,137,1971
Occupational Exposure Limit - AUSTRALIA time-weighted average 0.1 ppm (0.8 mg/m3), short term exposure limit 0.2 ppm, JAN1993
Occupational Exposure Limit - AUSTRIA MAK 0.1 ppm (0.8 mg/m3), JAN1999
Occupational Exposure Limit - BELGIUM time-weighted average 0.1 ppm (0.23 mg/m3), short term exposure limit 0.2 ppm, JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 0.1 ppm (0.8 mg/m3), JAN1999
Occupational Exposure Limit - FINLAND short term exposure limit 0.01 ppm (0.08 mg/m3), JAN1999
Occupational Exposure Limit - FRANCE VME 0.1 ppm (0.8 mg/m3), JAN1999
Occupational Exposure Limit - GERMANY MAK 0.1 ppm (0.8 mg/m3), JAN1999
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 0.08 mg/m3, 2003
Occupational Exposure Limit - RUSSIA short term exposure limit 0.1 mg/m3, Skin, JAN1993
Occupational Exposure Limit - SWITZERLAND MAK- week 0.1 ppm (0.8 mg/m3), KZG- week 0.2 ppm, JAN1999
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 0.01 ppm (0.08 mg(Fe)/m3, sKIN, Skin, SEP2000
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

short term exposure limit 0.2 (Fe)ppm
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
short term exposure limit 0.2 (Fe)ppm


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO IRON PENTACARBONYL (as Fe)-air time-weighted average 0.1 ppm;
short term exposure limit 0.2 ppm 		NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X6270;
Number of Industries 1;
Total Number of Facilities 7;
Number of Occupations 1;
Total Number of Employees Exposed 1,822;
Total Number of Female Employees Exposed 272


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used to make finely divided iron, also used as antiknock agent and catalyst
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
34ZIAG "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969
AEHLAU Archives of Environmental Health. (Heldref Pub., 4000 Albemarle St., NW, Washington, DC 20016) V.1- 1960-
AMIHAB AMA Archives of Industrial Health. (Chicago, IL) V.11-21, 1955-60. For publisher information, see AEHLAU.
BJIMAG British Journal of Industrial Medicine. (British Medical Journal, Box 560B, Kennebunkport, ME 04046) V.1- 1944-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
EPASR* United States Environmental Protection Agency, Office of Pesticides and Toxic Substances. (U.S. Environmental Protection Agency, 401 M St., SW, Washington, DC 20460) History unknown.
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU.
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-

Used to make finely divided iron, also used as antiknock agent and catalyst

NIOSH PROFILE (IRON AND ITS COMPOUNDS), SRC, 3/82

RTECS Compound Description:
   Organometallic

ALT CAS #: 37220-42-1
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