RTECS:NN1575000 The Registry of Toxic Effects of Chemical Substances | CDC/NIOSH

The Registry of Toxic Effects of Chemical Substances

Iodine

RTECS #: NN1575000

CAS #: 7553-56-2

UPDATE: November 2004 MW: 253.80 MF: I₂

NOTE:

TOXICITY DATA HAVE NOT BEEN EVALUATED. OMISSION OF A SUBSTANCE OR NOTATION DOES NOT IMPLY ANY RELIEF FROM REGULATORY RESPONSIBILITY.

TABLE OF CONTENTS:

SYNONYMS:

REPRODUCTIVE EFFECTS DATA:

ACUTE TOXICITY DATA:

OTHER MULTIPLE DOSE DATA:

REVIEWS:

STANDARDS AND REGULATIONS:

NIOSH DOCUMENTATION AND SURVEILLANCE:

STATUS IN FEDERAL AGENCIES:

REFERENCES:

SYNONYMS:

IODE (French)

Iodine crystals

Iodine sublimed

Iodine (ACGIH:OSHA)

Iodio (Italian)

Jod (German, Polish)

Jood (Dutch)

SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

MUTATION DATA AND REFERENCES:
SYSTEM TEST ROUTE/
ORGANISM/
TISSUE DOSE REFERENCE
N/R N/R N/R N/R

REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
oral
rat lowest published toxic dose: 1,100 mg/kg (1-22 day pregnant) Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive) JONUAI 84,107,1964
oral
rat lowest published toxic dose: 2,750 mg/kg (1-22 day pregnant) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) JONUAI 84,107,1964
oral
rabbit lowest published toxic dose: 15 mg/kg (30-31 day pregnant) Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive)

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) JONUAI 87,394,1965

TUMORIGENIC DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
inhalation
human lowest published toxic concentration: 1 mg/m³ Behavioral: Muscle weakness

Behavioral: Coma

Lung, Thorax, or Respiration: Acute pulmonary edema VCVN5* -,400,1989
inhalation
mammal (species unspecified) lowest published toxic concentration: 100 mg/m³ Endocrine: Other changes VCVN5* -,399,1989
inhalation
mammal (species unspecified) lowest published toxic concentration: 10 mg/m³ Lung, Thorax, or Respiration: Cough VCVN5* -,399,1989
inhalation
rat lowest published lethal concentration: 137 ppm/1 hour Eye: Lacrimation

Behavioral: Somnolence (general depressed activity)

Nutritional and Gross Metabolic: Body temperature decrease NTIS** OTS0555278
inhalation
rat lowest published toxic concentration: 100 mg/m³ Eye: Lacrimation

Lung, Thorax, or Respiration: Respiratory depression

Nutritional and Gross Metabolic: Body temperature decrease VCVN5* -,399,1989
intravenous
dog lowest published lethal dose: 40 mg/kg N/R HBTXAC 5,76,1959
oral
dog lowest published lethal dose: 800 mg/kg N/R HBAMAK 4,1289,1935
oral
human lowest published lethal dose: 28 mg/kg Gastrointestinal: Hypermotility, diarrhea

Gastrointestinal: Other changes 34ZIAG -,330,1969
oral
human lowest published toxic dose: 0.7 gm/kg Behavioral: Muscle weakness

Gastrointestinal: Nausea or vomiting

Kidney, Ureter, and Bladder: Renal function tests depressed VCVN5* -,400,1989
oral
human lowest published toxic dose: 25 mg/kg Lung, Thorax, or Respiration: Respiratory obstruction

Lung, Thorax, or Respiration: Dyspnea

Gastrointestinal: Hypermotility, diarrhea VCVN5* -,400,1989
oral
mouse lethal dose (50 percent kill): 22 gm/kg N/R DRFUD4 4,876,1979
oral
mouse lethal dose (50 percent kill): 1,000 mg/kg Behavioral: Change in motor activity (specific assay) VCVN5* -,399,1989
oral
rat lethal dose (50 percent kill): 14 gm/kg N/R DRFUD4 4,876,1979
oral
rabbit lethal dose (50 percent kill): 10 gm/kg N/R DRFUD4 4,876,1979
oral
rabbit lowest published lethal dose: 5 mg/kg Blood: Other hemolysis with or without anemia VCVN5* -,399,1989
oral
woman lowest published toxic dose: 26 mg/kg/1 year- intermittent Endocrine: Evidence of thyroid hyperfunction PGMJAO 62,661,1986
subcutaneous
mouse lethal dose (50 percent kill): >8,650 mg/kg N/R NIIRDN -,1226,1990
subcutaneous
rat lethal dose (50 percent kill): 10,500 mg/kg N/R NIIRDN -,1226,1990
subcutaneous
rabbit lowest published lethal dose: 175 mg/kg N/R HBTXAC 5,76,1959
unreported route
man lowest published lethal dose: 29 mg/kg N/R 85DCAI 2,73,1970

OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
inhalation
mammal (species unspecified) lowest published toxic concentration: 0.5 mg/m³/24 hour/8 week- continuous Olfaction: Change in sensation of smell VCVN5* -,400,1989
inhalation
rat lowest published toxic concentration: 3.1 mg/m³/24 hour/13 week- continuous Liver: Liver function tests impaired

Kidney, Ureter, and Bladder: Renal function tests depressed

Endocrine: Other changes VCVN5* -,400,1989
inhalation
rat lowest published toxic concentration: 1.38 mg/m³/24 hour/13 week- continuous Behavioral: Change in motor activity (specific assay)

Behavioral: Aggression VCVN5* -,400,1989
oral
rat lowest published toxic dose: 746 mg/kg/14 week- continuous Blood: Other changes JTEHD6 32,89,1991

REVIEWS:
ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value ceiling concentration 0.1 ppm DTLVS* TLV/BEI,2003
TOXICOLOGY REVIEW
FOREAE 7,313,1942
TOXICOLOGY REVIEW
KOTTAM 11,1300,1975

STANDARDS AND REGULATIONS:
ORGANIZATION STANDARD
REFERENCE

Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Supported RBREV* -,258,1998
Mine Safety and Health Administration (MSHA) STANDARD air-ceiling concentration 0.1 ppm (1 mg/m³) DTLVS* 3,135,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) ceiling concentration 0.1 ppm (1 mg/m³) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) ceiling concentration 0.1 ppm (1 mg/m³) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) ceiling concentration 0.1 ppm (1 mg/m³) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) ceiling concentration 0.1 ppm (1 mg/m³) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - ARAB Republic of Egypt time-weighted average 0.1 ppm (0.1 mg/m³), JAN1993
Occupational Exposure Limit - AUSTRALIA time-weighted average 0.1 ppm (1 mg/m³), JAN1993
Occupational Exposure Limit - AUSTRIA MAK 0,1 ppm (1 mg/m³), JAN1999
Occupational Exposure Limit - BELGIUM short term exposure limit 0.1 ppm (1 mg/m³), JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 0.1 ppm (1 mg/m³), JAN1999
Occupational Exposure Limit - FINLAND short term exposure limit 0.1 ppm (1 mg/m³), Skin, JAN1999
Occupational Exposure Limit - FRANCE VLE 0.1 ppm (1 mg/m³), JAN1999
Occupational Exposure Limit - GERMANY MAK 0.1 ppm (1 mg/m³), JAN1999
Occupational Exposure Limit - THE NETHERLANDS MAC- continuous 1 mg/m³, 2003
Occupational Exposure Limit - JAPAN Occupational Exposure Limit 0.1 ppm (1 mg/m³), JAN1999
Occupational Exposure Limit - NORWAY time-weighted average 0.1 ppm (1 mg/m³), JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 0.1 ppm (1 mg/m³), JAN1993
Occupational Exposure Limit - POLAND MAC(time-weighted average) 1 mg/m³, JAN1999
Occupational Exposure Limit - RUSSIA time-weighted average 0.1 ppm, short term exposure limit 1 mg/m³, Skin, JAN1993
Occupational Exposure Limit - SWEDEN CEILING 0.1 ppm (1 mg/m³), JAN1999
Occupational Exposure Limit - SWITZERLAND MAK- week 0.1 ppm (1 mg/m³), KZG- week 0.2 ppm, JAN1999
Occupational Exposure Limit - THAILAND time-weighted average 0.1 ppm (1 mg/m³), JAN1993
Occupational Exposure Limit - TURKEY time-weighted average 0.1 ppm (1 mg/m³), JAN1993
Occupational Exposure Limit - UNITED KINGDOM short term exposure limit 0.1 ppm (1.1 mg/m³), SEP2000
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

ceiling concentration 0.1 ppm
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
ceiling concentration 0.1 ppm

NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO IODINE-air ceiling concentration 0.1 ppm NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 40030;
Number of Industries 51;
Total Number of Facilities 7,490;
Number of Occupations 46;
Total Number of Employees Exposed 124,917
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 40030;
Number of Industries 63;
Total Number of Facilities 6,179;
Number of Occupations 77;
Total Number of Employees Exposed 204,902;
Total Number of Female Employees Exposed 129,889

STATUS IN FEDERAL AGENCIES:
ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as a drinking water disinfectant
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Iodine, 6005
OSHA ANALYTICAL METHOD #ID-177

REFERENCES:
CODEN
REFERENCE

34ZIAG "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969
85DCAI "Poisoning; Toxicology, Symptoms, Treatments," 2nd ed., Arena, J.M., Springfield, IL, C.C. Thomas, 1970
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
FOREAE Food Research. (Champaign, IL) V.1-25, 1936-60. For publisher information, see JFDSAZ.
HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." (Leipzig, Ger. Dem. Rep.)
HBTXAC "Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders Co., 1956-59
JONUAI Journal of Nutrition. (Subscription Dept., 9650 Rockville Pike, Bethesda, MD 20014) V.1- 1928-
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76-
KOTTAM Kogai to Taisaku. Journal of Environmental Pollution Control. (Kogai Taisaku Gijutsu Dokokai, Shuwa-Akasaka Bldg., 9-1-244, Akasaka, Minato-ku, Tokyo 107, Japan) V.1- 1965-
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan)
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
PGMJAO Postgraduate Medical Journal. (Blackwell Scientific Pub. Ltd., POB 88, Oxford, UK) V.1- 1925-
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
VCVN5* "Vrednie chemichescie veshestva. Neorganicheskie soedinenia elementov V-VII groopp" (Hazardous substances. Inornanic substances containing V-VII group elements), Bandman A.L. et al., Chimia, 1989.

Used as a drinking water disinfectant

NIOSH PROFILE (PHOTOGRAPHIC PROCESSING), FIRL, 4/78

FDA-over the counter drug

RTECS Compound Description:
Reproductive Effector
Human Data

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