The Registry of Toxic Effects of Chemical Substances

1H - Imidazole, 1 - (2 - (2,4 - dichlorophenyl) - 2 - (2 - propenyloxy) ethyl) -

RTECS #: NI4776000

CAS #: 35554-44-0

UPDATE: August 2003 MW: 297.20 MF: C14H14Cl2N2O


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. STANDARDS AND REGULATIONS:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. (+ - ) - 1 - (beta - (Allyloxy) - 2,4 - dichlorophenethyl) imidazole
  2. CGA 41333
  3. Chloramizol
  4. Deccozil S 75
  5. Enilconazole
  6. Eniloconazol (SP)
  1. 1 - (2 - (2,4 - Dichlorophenyl) - 2 - (2 - propenyloxy) ethyl) - 1H - imidazole
  2. 1 - (2 - (2,4 - Dichlorphenyl) - 2 - (2 - propenyloxy) aethyl) - 1H - imidazol (German)
  3. Fungaflor
  4. Imazalil
  5. R 23979


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		49 mg moderate ARZNAD 31,309,1981


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 2,240 mg/kg (16-22 day pregnant/21 day after birth) Reproductive: Effects on newborn: Stillbirth

Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth) 		ARZNAD 31,309,1981
oral
rat 		lowest published toxic dose: 560 mg/kg (16-22 day pregnant/21 day after birth) Reproductive: Effects on newborn: Weaning or lactation index (e.g., # alive at weaning per # alive at day 4) ARZNAD 31,309,1981
oral
rat 		lowest published toxic dose: 4,160 mg/kg (multigenerations) Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth) ARZNAD 31,309,1981
oral
rabbit 		lowest published toxic dose: 8,190 µg/kg (6-18 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) ARZNAD 31,309,1981
oral
rabbit 		lowest published toxic dose: 32,500 µg/kg (6-18 day pregnant) Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive) ARZNAD 31,309,1981


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lethal concentration (50 percent kill): 16 gm/m3/4 hour N/R PEMNDP 9,482,1991
intraperitoneal
rat 		lethal dose (50 percent kill): 155 mg/kg Behavioral: Muscle weakness

Behavioral: Ataxia

Skin and Appendages: Other: Hair 		ARZNAD 31,309,1981
oral
dog 		lethal dose (50 percent kill): >640 mg/kg Gastrointestinal: Hypermotility, diarrhea ARZNAD 31,309,1981
oral
rat 		lethal dose (50 percent kill): 227 mg/kg Behavioral: Muscle weakness

Behavioral: Ataxia

Skin and Appendages: Other: Hair 		ARZNAD 31,309,1981
skin
rat 		lethal dose (50 percent kill): 4,200 mg/kg N/R PEMNDP 9,482,1991
skin
rabbit 		lethal dose (50 percent kill): 4,200 mg/kg N/R 85JFAN A230,1983


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
dog 		lowest published toxic dose: 3,640 mg/kg/2 year- intermittent Behavioral: Food intake (animal)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		ARZNAD 31,309,1981


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Supported RBREV* -,185,1998


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
N/R N/R N/R


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
85JFAN "Agrochemicals Handbook," with updates, Hartley, D., and H. Kidd, eds., Nottingham, Royal Soc. of Chemistry, 1983-86
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4 7QG, UK) V.1- 1968-
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998

Used as a fungicide

RTECS Compound Description:
   Agricultural Chemical
   Drug
   Reproductive Effector
   Primary Irritant

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