The Registry of Toxic Effects of Chemical Substances

Hydroxylamine, hydrochloride

RTECS #: NC3675000

CAS #: 5470-11-1

UPDATE: October 1997 MW: 69.50 MF: ClH•H3NO


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. NIOSH DOCUMENTATION AND SURVEILLANCE:
  6. STATUS IN FEDERAL AGENCIES:
  7. REFERENCES:

SYNONYMS:

  1. Hydroxyamine hydrochloride
  2. Hydroxyammonium chloride
  3. Hydroxylamine chloride
  1. Hydroxylamine chloride (1:1)
  2. Hydroxylammonium chloride
  3. Oxammonium hydrochloride


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis parenteral
grasshopper 		2,500 µg PISCAD 59(Pt 3),480,1972
cytogenetic analysis hamster other cell types 72 µmol/L JNCIAM 32,667,1964
cytogenetic analysis human leukocyte 25 mg/L HEREAY 69,19,1971
cytogenetic analysis mammal (species unspecified) lymphocyte 500 mg/L MUREAV 81,63,1981
cytogenetic analysis monkey kidney 25 mg/L ECREAL 57,193,1969
cytogenetic analysis mouse embryo 72 µmol/L JNCIAM 32,667,1964
DNA damage Bacillus subtilis 100 mmol/L BBACAQ 155,476,1968
DNA repair Escherichia coli 500 µg/plate JJIND8 62,873,1979
mutation in microorganisms Bacillus subtilis 1 mole/L (-enzymatic activation step) MGGEAE 147,1,1976
mutation in microorganisms mouse lymphocyte 220 mg/L (+enzymatic activation step) EMMUEG 12(Suppl 13),103,1988
mutation in microorganisms other microorganisms 200 mmol/L (-enzymatic activation step) MUREAV 8,451,1969
mutation in microorganisms other microorganisms 1 mole/L (-enzymatic activation step) VIRLAX 81,192,1977
mutation in microorganisms other microorganisms 20 mmol/L (-enzymatic activation step) SCIEAS 148,507,1965
mutation in microorganisms other microorganisms 450 mmol/L (-enzymatic activation step) MGGEAE 141,207,1975
mutation in microorganisms other microorganisms 1 mole/L (-enzymatic activation step) PNASA6 68,3158,1971
mutation in microorganisms other microorganisms 1 mole/L (-enzymatic activation step) MUREAV 73,1,1980
mutation in microorganisms other microorganisms 2 mole/L (-enzymatic activation step) MUREAV 24,245,1974
mutation in microorganisms other microorganisms 10 mmol/L (-enzymatic activation step) MUREAV 49,163,1978
mutation in microorganisms Schizosaccharomyces pombe 1 mole/L (-enzymatic activation step) MUREAV 4,441,1967
micronucleus test monkey kidney 50 mg/L ECREAL 57,193,1969
gene conversion and mitotic recombination Saccharomyes cerevisiae 200 ppm JJIND8 62,901,1979
mutation in mammalian somatic cells mouse lymphocyte 31,300 µg/L EMMUEG 12(Suppl 13),103,1988
morphological transform rat embryo 19,500 ng/plate JJATDK 1,190,1981
other mutation test systems human other cell types 10 mg/L FOBLAN 20,286,1974
other mutation test systems monkey kidney 25 mg/L ECREAL 57,193,1969
sister chromatid exchange hamster lung 5 mmol/L HUGEDQ 54,155,1980
sister chromatid exchange mammal (species unspecified) lymphocyte 25 mg/L IJEBA6 20,726,1982
specific locus test oral
Drosophila melanogaster 		30 mmol/L IJEBA6 17,61,1979


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lethal dose (50 percent kill): 10 mg/kg N/R NTIS** AD277-689
oral
mouse 		lethal dose (50 percent kill): 408 mg/kg N/R APTOA6 6,285,1950
oral
rat 		lethal dose (50 percent kill): 141 mg/kg Behavioral: Convulsions or effect on seizure threshold NTIS** OTS0555279
subcutaneous
dog 		lowest published lethal dose: 70 mg/kg N/R HBAMAK 4,1289,1935
subcutaneous
mouse 		lethal dose (50 percent kill): 125 mg/kg N/R ABMGAJ 21,635,1968


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 49,500 mg/kg/25 week- intermittent Endocrine: Changes in spleen weight

Endocrine: Changes in thyroid weight 		APTOA6 6,285,1950
oral
rat 		lowest published toxic dose: 2,478 mg/kg/6 day- continuous Behavioral: Food intake (animal)

Blood: Changes in leukocyte (WBC) count

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		NTIS** OTS0555279


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 38950;
Number of Industries 18;
Total Number of Facilities 1,202;
Number of Occupations 11;
Total Number of Employees Exposed 6,578
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 38950;
Number of Industries 20;
Total Number of Facilities 1,258;
Number of Occupations 26;
Total Number of Employees Exposed 15,258;
Total Number of Female Employees Exposed 4,469


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Positive: Cell transform.-RLV F344 rat embryo
EPA GENETOX PROGRAM 1988, Positive: E coli polA without S9; S cerevisiae-forward mutation
EPA GENETOX PROGRAM 1988, Positive: S cerevisiae-homozygosis
EPA GENETOX PROGRAM 1988, Negative: Cell transform.-BALB/c-3T3; SHE-clonal assay
EPA GENETOX PROGRAM 1988, Negative: Histidine reversion-Ames test
EPA GENETOX PROGRAM 1988, Negative: In vitro UDS-human fibroblast
EPA GENETOX PROGRAM 1988, Inconclusive: D melanogaster Sex-linked lethal
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
ABMGAJ Acta Biologica et Medica Germanica. (Berlin, Ger. Dem. Rep.) V.1-41, 1958-82. For publisher information, see BBIADT.
APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59, 1945-86. For publisher information, see PHTOEH
BBACAQ Biochimica et Biophysica Acta. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1947-
ECREAL Experimental Cell Research. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.10- 1950-
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
FOBLAN Folia Biologica (Prague). (Academic Press Inc. Ltd., 24-28 Oval Rd., London NW1 7DX, UK) V.1- 1955-
HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." (Leipzig, Ger. Dem. Rep.)
HEREAY Hereditas (Lund, Sweden). (Gjoerloffsgatan 121, S-261 34 Landskrona, Sweden) V.1- 1947-
HUGEDQ Human Genetics. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.31- 1976-
IJEBA6 Indian Journal of Experimental Biology. (Publications & Information Directorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-
JJATDK JAT, Journal of Applied Toxicology. (John Wiley & Sons Ltd., Baffins Lane, Chichester, W. Sussex PO19 1UD, UK) V.1- 1981-
JJIND8 JNCI, Journal of the National Cancer Institute. (Washington, DC) V.61-79, 1978-87. For publisher information, see JNCIEQ.
JNCIAM Journal of the National Cancer Institute. (Washington, DC) V.1-60, 1940-78. For publisher information, see JJIND8.
MGGEAE Molecular and General Genetics. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.99- 1967-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
PISCAD Proceedings of the Indian Science Congress. (Indian Science Congress Assoc., 14, Dr. Biresh Guha St., Calcutta, 700017, India) 1st- 1914-
PNASA6 Proceedings of the National Academy of Sciences of the United States of America. (National Academy of Sciences, Printing & Pub. Office, 2101 Constitution Ave., Washington, DC 20418) V.1- 1915-
SCIEAS Science. (American Assoc. for the Advancement of Science, 1333 H St., NW, Washington, DC 20005) V.1- 1895-
VIRLAX Virology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1955-

NIOSH PROFILE (PHOTOGRAPHIC PROCESSING), FIRL, 4/78

RTECS Compound Description:
   Mutagen

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