The Registry of Toxic Effects of Chemical Substances

Hydroxylamine

RTECS #: NC2975000

CAS #: 7803-49-8

UPDATE: October 1997 MW: 33.04 MF: H3NO


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. ACUTE TOXICITY DATA:
  4. NIOSH DOCUMENTATION AND SURVEILLANCE:
  5. STATUS IN FEDERAL AGENCIES:
  6. REFERENCES:

SYNONYMS:

  1. Oxammonium


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis human fibroblast 300 µmol/L MUREAV 4,353,1967
cytogenetic analysis human leukocyte 25 mg/L CBINA8 6,375,1973
DNA damage Escherichia coli 50 mmol/L BBACAQ 119,434,1966
DNA damage other microorganisms 1 mole/L MUREAV 25,235,1974
DNA inhibition human lymphocyte 360 µmol/L TXAPA9 33,38,1975
DNA inhibition human HeLa cell 10 mmol/L MUREAV 93,447,1982
DNA repair Bacillus subtilis 23 gm/L MUREAV 16,165,1972
DNA repair Salmonella typhimurium 5 pph AGACBH 4,286,1974
unscheduled DNA synthesis other microorganisms 1 mole/L DBIOAM 217,309,1974
mutation in microorganisms Bacillus subtilis 1 mole/L (-enzymatic activation step) PNASA6 48,1796,1962
mutation in microorganisms Escherichia coli 5 pph (-enzymatic activation step) AGACBH 4,286,1974
mutation in microorganisms Haemophilus influenzae 140 mmol/L/5 minute (-enzymatic activation step) MUREAV 30,9,1975
mutation in microorganisms Neurospora crassa 1 mole/L (-enzymatic activation step) MUREAV 12,35,1971
mutation in microorganisms other microorganisms 250 mmol/L (-enzymatic activation step) IJEBA6 15,1068,1977
mutation in microorganisms other microorganisms 250 mmol/L/20 minute (-enzymatic activation step) MUREAV 7,19,1969
mutation in microorganisms other microorganisms 1 mole/L (-enzymatic activation step) JMOBAK 9,352,1964
mutation in microorganisms other microorganisms 1 mg/L (-enzymatic activation step) MUREAV 74,113,1980
mutation in microorganisms other microorganisms 20 mmol/L (-enzymatic activation step) SCIEAS 148,507,1965
mutation in microorganisms other microorganisms 400 mmol/L (-enzymatic activation step) MUREAV 22,223,1974
mutation in microorganisms other microorganisms 100 mmol/L (-enzymatic activation step) AVIRA2 16,47,1972
mutation in microorganisms other microorganisms 10 mmol/L (-enzymatic activation step) MUREAV 22,95,1974
mutation in microorganisms other microorganisms 1 mole/L (-enzymatic activation step) BBRCA9 39,156,1970
mutation in microorganisms other microorganisms 1 mole/L (-enzymatic activation step) JOVIAM 7,673,1971
mutation in microorganisms other microorganisms 1 mole/L (-enzymatic activation step) MGGEAE 128,359,1974
mutation in microorganisms other microorganisms 1 mole/L (-enzymatic activation step) SOGEBZ 6,616,1970
mutation in microorganisms other microorganisms 250 mmol/plate (-enzymatic activation step) PCJOAU 15,482,1981
mutation in microorganisms other microorganisms 1 mole/L (-enzymatic activation step) JCPBAN 58,1005,1961
mutation in microorganisms other microorganisms 50 mmol/L (-enzymatic activation step) MGGEAE 179,191,1980
mutation in microorganisms other microorganisms 250 mmol/plate (-enzymatic activation step) BZARAZ 32,1146,1979
mutation in microorganisms Salmonella typhimurium 5 pph (+enzymatic activation step) AGACBH 4,286,1974
other mutation test systems other microorganisms 2 mole/L VIRLAX 49,462,1972
phage inhibition capacity Bacillus subtilis 1 mole/L IJEBA6 22,338,1984
sex chromosome loss and nondisjunction oral
Drosophila melanogaster 		30 mmol/L MUREAV 16,363,1972


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lethal dose (50 percent kill): 60 mg/kg N/R JPETAB 165,30,1969
intraperitoneal
rat 		lethal dose (50 percent kill): 59 mg/kg N/R CNREA8 26,1448,1966
subcutaneous
rat 		lethal dose (50 percent kill): 29 mg/kg N/R JPETAB 119,444,1957
unreported route
mouse 		lethal dose (50 percent kill): 175 mg/kg N/R BJCAAI 6,160,1952


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 84783;
Number of Industries 3;
Total Number of Facilities 116;
Number of Occupations 5;
Total Number of Employees Exposed 1,722
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 84783;
Number of Industries 5;
Total Number of Facilities 112;
Number of Occupations 9;
Total Number of Employees Exposed 2,689;
Total Number of Female Employees Exposed 1,481


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Positive: Cell transform.-RLV F344 rat embryo
EPA GENETOX PROGRAM 1988, Positive: N crassa-forward mutation; S pombe-forward mutation
EPA GENETOX PROGRAM 1988, Negative: In vitro cytogenetics-human lymphocyte
EPA GENETOX PROGRAM 1988, Negative: D melanogaster-whole sex chrom. loss
EPA GENETOX PROGRAM 1988, Inconclusive: Carcinogenicity-mouse/rat
EPA GENETOX PROGRAM 1988, Inconclusive: D melanogaster-nondisjunction
EPA GENETOX PROGRAM 1988, Inconclusive: D melanogaster Sex-linked lethal
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
AGACBH Agents and Actions, A Swiss Journal of Pharmacology. (Birkhaeuser Verlag, POB 133, CH-4010 Basel, Switzerland) V.1- 1969/70-
AVIRA2 Acta Virologica (English Edition). (Academic Press Inc. Ltd., 24-28 Oval Rd., London NW1 7DX, UK) V.1- 1957-
BBACAQ Biochimica et Biophysica Acta. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1947-
BBRCA9 Biochemical and Biophysical Research Communications. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
BJCAAI British Journal of Cancer. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants. RG21 2XS, UK) V.1- 1947-
BZARAZ Biologicheskii Zhurnal Armenii. Biological Journal of Armenia. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.19- 1966-
CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1969-
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941-
DBIOAM Doklady Biochemistry (English Translation). Translation of DANKAS: Biochemistry Section. (Plenum Pub. Corp., 233 Spring Street, New York, NY 11013) V.112- 1957-
IJEBA6 Indian Journal of Experimental Biology. (Publications & Information Directorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-
JCPBAN Journal de Chimie Physique et de Physico-Chimie Biologique. (CDR-Centrale des Revues, 11, rue Gossin, F-92543 Montrouge Cedex, France) V.1- 1903-
JMOBAK Journal of Molecular Biology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
JOVIAM Journal of Virology. (American Soc. for Microbiology, 1913 I St., NW, Washington, DC 20006) V.1- 1967-
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
MGGEAE Molecular and General Genetics. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.99- 1967-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
PCJOAU Pharmaceutical Chemistry Journal (English Translation). Translation of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No.1- 1967-
PNASA6 Proceedings of the National Academy of Sciences of the United States of America. (National Academy of Sciences, Printing & Pub. Office, 2101 Constitution Ave., Washington, DC 20418) V.1- 1915-
SCIEAS Science. (American Assoc. for the Advancement of Science, 1333 H St., NW, Washington, DC 20005) V.1- 1895-
SOGEBZ Soviet Genetics. English translation of GNKAA5. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) V.2- 1966-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
VIRLAX Virology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1955-

RTECS Compound Description:
   Mutagen

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