The Registry of Toxic Effects of Chemical Substances

Hydrogen peroxide, 30%

RTECS #: MX0899000

CAS #: 7722-84-1

UPDATE: July 2000 MW: 34.02 MF: H2O2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. TUMORIGENIC DATA:
  4. ACUTE TOXICITY DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. Albone 35
  2. Albone 50
  3. Albone 70
  4. Albone 35CG
  5. Albone 50CG
  6. Albone 70CG
  1. Interox
  2. Kastone
  3. Hydrogen peroxide, solution, 30%
  4. Perone 30
  5. Perone 35
  6. Perone 50


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis hamster ovary 60 µmol/L EMMUEG 26,248,1995
cytogenetic analysis human embryo 20 µmol/L MUREAV 172,245,1986
DNA damage human lymphocyte 9 µmol/L ECREAL 175,184,1988
DNA damage rat lymphocyte 50 µmol/L JTEHD6 23,407,1988
DNA inhibition hamster ovary 250 µmol/L CBINA8 76,129,1990
mutation in microorganisms Neurospora crassa 500 nmol/L (-enzymatic activation step) MUREAV 374,169,1997
mutation in microorganisms Salmonella typhimurium 4,400 µmol/plate (+enzymatic activation step) TCMUD8 9,211,1989
mutation in mammalian somatic cells hamster lung 1 mmol/L MUREAV 192,65,1987
other mutation test systems human embryo 50 µmol/L MUREAV 172,245,1986
sister chromatid exchange hamster ovary 40 µmol/L EMMUEG 26,248,1995


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lowest published toxic dose: 622 gm/kg/2 year- continuous Tumorigenic: Carcinogenic by RTECS criteria

Gastrointestinal: Tumors 		HIUN**
oral
mouse 		toxic dose : 155 gm/kg/2 year- continuous Tumorigenic: Carcinogenic by RTECS criteria

Gastrointestinal: Tumors 		HIUN**


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intravenous
mouse 		lethal dose (50 percent kill): >50 gm/kg N/R HYHPDO 5,39,1980
oral
man 		lowest published lethal dose: 1,429 mg/kg Behavioral: Coma

Gastrointestinal: Changes in structure or function of esophagus

Gastrointestinal: Nausea or vomiting 		SMEZA5 17(1),53,1974
oral
rabbit 		lethal dose (50 percent kill): 820 mg/kg Gastrointestinal: Peritonitis

Blood: Pigmented or nucleated red blood cells

Blood: Changes in leukocyte (WBC) count 		STGNBT -,39,1999
oral
woman 		lowest published lethal dose: 2,626 µg/kg Behavioral: Coma

Lung, Thorax, or Respiration: Cyanosis

Gastrointestinal: Nausea or vomiting 		SMEZA5 17(1),53,1974
oral
woman 		lowest published toxic dose: 1,200 mg/kg Gastrointestinal: Gastritis

Gastrointestinal: Nausea or vomiting 		AEMED3 21,1391,1992
skin
rat 		lethal dose (50 percent kill): 3 gm/kg N/R STGNBT -,39,1999


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
International Agency for Research on Cancer (IARC) Cancer Review Animal Limited Evidence IMEMDT 36,285,1985
International Agency for Research on Cancer (IARC) Cancer Review Group 3 IMSUDL 7,56,1987


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 1 ppm (1.4 mg/m3) DTLVS* 3,131,1971
Occupational Exposure Limit - AUSTRALIA time-weighted average 1 ppm (1.5 mg/m3), JAN1993
Occupational Exposure Limit - AUSTRIA MAK 1 ppm (1.4 mg/m3), JAN1999
Occupational Exposure Limit - BELGIUM time-weighted average 1 ppm (1.4 mg/m3), JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 1 ppm (1.4 mg/m3), JAN1999
Occupational Exposure Limit - FINLAND time-weighted average 1 ppm (1.4 mg/m3), short term exposure limit 3 ppm (4.2 mg/m3), JAN1993
Occupational Exposure Limit - FRANCE VME 1 ppm (1.5 mg/m3), JAN1999
Occupational Exposure Limit - GERMANY MAK 1 ppm (1.4 mg/m3), JAN1999
Occupational Exposure Limit - NORWAY time-weighted average 1 ppm (1.4 mg/m3), JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 1 ppm (1.4 mg/m3), JAN1993
Occupational Exposure Limit - POLAND MAC(time-weighted average) 1.5 mg/m3, MAC(short term exposure limit) 4 mg/m3, JAN1999
Occupational Exposure Limit - SWEDEN time-weighted average 1 ppm (1.7 mg/m3), JAN1999
Occupational Exposure Limit - TURKEY time-weighted average 1 ppm (1.4 mg/m3), JAN1993
Occupational Exposure Limit - UNITED KINGDOM LTEL 1 ppm (1.5 mg/m3), short term exposure limit 2 ppm (3 mg/m3), JAN1993


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 38605;
Number of Industries 168;
Total Number of Facilities 19,597;
Number of Occupations 83;
Total Number of Employees Exposed 422,227
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 38605;
Number of Industries 171;
Total Number of Facilities 22,930;
Number of Occupations 142;
Total Number of Employees Exposed 1,006,752;
Total Number of Female Employees Exposed 727,702


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Positive: N crassa-reversion; E coli polA without S9
EPA GENETOX PROGRAM 1988, Positive: In vitro UDS-human fibroblast; S pombe-reversion
EPA GENETOX PROGRAM 1988, Inconclusive: Histidine reversion-Ames test
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used for bleaching, chemical intermediate, waste treatment, etching, transistors
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-8799
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
AEMED3 Annals of Emergency Medicine. (American College of Emergency Physicians, 1125 Executive Circle, Irving, TX 75038)
CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1969-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
ECREAL Experimental Cell Research. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.10- 1950-
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
HYHPDO Hunan Yixueyuan Xuebao. Journal of Hunan Medical College. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) Beginning history not known.
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979-
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
SMEZA5 Sudebno-Meditsinskaya Ekspertiza. Forensic Medical Examination. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1958-
STGNBT "Spravochnik po Toksikologii i Gigienicheskim Normativam (PDK) Potentsial'no Opasnykh Khimicheskikh Veshchestv" Kushneva, V.S., and R.B. Gorshkova, eds. 46, Zhivopisnaya St., 123182, Moscow, Russia, IzdAT 1999
TCMUD8 Teratogenesis, Carcinogenesis, and Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1980-

Used for bleaching, chemical intermediate, waste treatment, etching, transistors

RTECS Compound Description:
   Tumorigen
   Mutagen
   Human Data

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