The Registry of Toxic Effects of Chemical Substances

Hydrofluoric acid

RTECS #: MW7875000

CAS #: 7664-39-3

UPDATE: August 2004 MW: 20.01 MF: FH


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. REPRODUCTIVE EFFECTS DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. REVIEWS:
  8. STANDARDS AND REGULATIONS:
  9. NIOSH DOCUMENTATION AND SURVEILLANCE:
  10. STATUS IN FEDERAL AGENCIES:
  11. REFERENCES:

SYNONYMS:

  1. Acide fluorhydrique (French)
  2. Acido fluoridrico (Italian)
  3. Fluorowodor (Polish)
  4. Fluorwasserstoff (German)
  5. Fluorwaterstof (Dutch)
  1. Hydrofluoride
  2. Hydrogen fluoride
  3. Hydrogen fluoride (ACGIH:OSHA)
  4. RCRA waste number U134
  5. Rubigine


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
human 		50 mg severe AMLTAS 37,110,1957
skin
rat 		50%/3 minute severe CTOXAO 40,861,2002


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis inhalation
rat 		1 mg/m3/6 hour/24 day- intermittent CYGEDX 9(1),40,1975
DNA damage inhalation
Drosophila melanogaster 		1,300 ppb/6 week ATENBP 5,117,1971
sex chromosome loss and nondisjunction inhalation
Drosophila melanogaster 		2,900 ppb FLUOA4 4,25,1971


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published toxic concentration: 470 µg/m3/4 hour (1-22 day pregnant) Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)

Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) 		GTPZAB 19(3),57,1975
inhalation
rat 		lowest published toxic concentration: 4,980 µg/m3/4 hour (1-22 day pregnant) Reproductive: Effects on embryo or fetus: Fetal death GTPZAB 19(3),57,1975


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
guinea pig 		lethal concentration (50 percent kill): 4,327 ppm/15 minute Eye: Lacrimation

Lung, Thorax, or Respiration: Respiratory depression

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		AIHAAP 24,253,1963
inhalation
guinea pig 		lowest published lethal concentration: 40 mg/m3/2 hour N/R VCVN5* -,349,1993
inhalation
guinea pig 		lowest published lethal concentration: 25 mg/m3/5 hour N/R VCVN5* -,349,1993
inhalation
human 		lowest published lethal concentration: 50 ppm/30 minute N/R 34ZIAG -,318,1969
inhalation
human 		lowest published lethal concentration: 200 mg/m3 N/R VCVN5* -,350,1993
inhalation
human 		lowest published toxic concentration: 25 mg/m3 Lung, Thorax, or Respiration: Cough

Eye: Conjunctiva irritation 		VCVN5* -,350,1993
inhalation
mammal (species unspecified) 		lowest published toxic concentration: 8 mg/m3 Lung, Thorax, or Respiration: Cough VCVN5* -,349,1993
inhalation
mammal (species unspecified) 		lowest published toxic concentration: 0.3 mg/m3 Eye: Other eye effects VCVN5* -,349,1993
inhalation
man 		lowest published toxic concentration: 100 mg/m3/1 minute Olfaction: Other olfaction effects

Eye: Conjunctiva irritation

Lung, Thorax, or Respiration: Cough 		JIDHAN 16,129,1934
inhalation
monkey 		lethal concentration (50 percent kill): 1,774 ppm/1 hour Behavioral: Coma

Lung, Thorax, or Respiration: Cyanosis

Gastrointestinal: Other changes 		AMRL** TR-70-77,1970
inhalation
mouse 		lethal concentration (50 percent kill): 342 ppm/1 hour Eye: Corneal damage

Eye: Other eye effects

Lung, Thorax, or Respiration: Dyspnea 		JCTODH 3,61,1976
inhalation
mouse 		lethal concentration (50 percent kill): 5,000 mg/m3/5 minute N/R VCVN5* -,349,1993
inhalation
mouse 		lethal concentration (50 percent kill): 270 mg/m3/60 minute N/R VCVN5* -,349,1993
inhalation
rat 		lethal concentration (50 percent kill): 1,276 ppm/1 hour Eye: Lacrimation

Behavioral: Change in motor activity (specific assay)

Gastrointestinal: Changes in structure or function of salivary glands 		AIHAAP 33,661,1972
inhalation
rat 		lethal concentration (50 percent kill): 1,100 mg/m3/60 minute N/R VCVN5* -,349,1993
inhalation
rat 		lowest published toxic concentration: 148 mg/m3/6 hour Olfaction: Other olfaction effects VCVN5* -,349,1993
inhalation
rabbit 		lowest published lethal concentration: 260 mg/m3/7 hour N/R AMIHBC 2,716,1950
inhalation
rabbit 		lowest published lethal concentration: 40 mg/m3/2 hour N/R VCVN5* -,349,1993
inhalation
rabbit 		lowest published lethal concentration: 25 mg/m3/5 hour N/R VCVN5* -,349,1993
intraperitoneal
rat 		lowest published lethal dose: 25 mg/kg N/R TXAPA9 13,76,1968
oral
man 		lowest published toxic dose: 143 mg/kg Cardiac: Arrythmias (indlucing changes in conduction)

Vascular: BP lowering not characterized in autonomic section

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) 		JTCTDW 35,307,1997
subcutaneous
frog 		lowest published lethal dose: 112 mg/kg N/R CRSBAW 124,133,1937
skin
mouse 		lowest published lethal dose: 500 mg/kg Peripheral Nerve and Sensation: Spastic paralysis with/without sensory change

Behavioral: Tremor

Lung, Thorax, or Respiration: Respiratory depression 		SAIGBL 17,281,1975


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
guinea pig 		lowest published toxic concentration: 0.15 mg/m3/24 hour/78 week- continuous Musculoskeletal: Changes in teeth and supporting structures VCVN5* -,350,1989
inhalation
rat 		lowest published toxic concentration: 300 µg/m3/24 hour/22 week- continuous Behavioral: Alteration of classical conditioning

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		GISAAA 30(5),11,1965
inhalation
rat 		lowest published toxic concentration: 252 µg/m3/6 hour/17 week- intermittent Blood: Changes in erythrocyte (RBC) count

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Monoamine oxidase

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases 		GISAAA 41(5),6,1976
inhalation
rat 		lowest published toxic concentration: 72 mg/m3/3 hour/3 day- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field VCVN5* -,349,1989
inhalation
rat 		lowest published toxic concentration: 10 mg/m3/24 hour/4 day- continuous Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) VCVN5* -,349,1989
inhalation
rat 		lowest published toxic concentration: 0.5 mg/m3/24 hour/17 week- continuous Musculoskeletal: Changes in teeth and supporting structures VCVN5* -,350,1989
inhalation
rat 		lowest published toxic concentration: 42.3 mg/m3/24 hour/6 week- continuous Musculoskeletal: Changes in teeth and supporting structures VCVN5* -,350,1989
subcutaneous
rat 		lowest published toxic dose: 364 mg/kg/26 week- intermittent Kidney, Ureter, and Bladder: Other changes

Musculoskeletal: Changes in teeth and supporting structures

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		FKIZA4 50,1397,1959


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value ceiling concentration 3 ppm(F) DTLVS* TLV/BEI,2003
TOXICOLOGY REVIEW
AMSSAQ 400,5,1963


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 3 ppm (2 mg/m3) DTLVS* 3,131,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 3 ppm CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 3 ppm (2 mg(F)/m3) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 3 ppm (2 mg(F)/m3) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 3 ppm (2 mg/m3) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - ARAB Republic of Egypt time-weighted average 2 ppm (2 mg/m3), JAN1993
Occupational Exposure Limit - AUSTRALIA time-weighted average 3 ppm (2.5 mg/m3), JAN1993
Occupational Exposure Limit - AUSTRIA MAK 3 ppm (2.5 mg/m3, JAN1999
Occupational Exposure Limit - BELGIUM short term exposure limit 3 ppm (2.6 mg/m3), JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 2 ppm (1.6 mg/m3), JAN1999
Occupational Exposure Limit - FINLAND CEILING 3 ppm, Skin, JAN1999
Occupational Exposure Limit - FRANCE VLE 3 ppm (2.5 mg/m3), JAN1999
Occupational Exposure Limit - GERMANY MAK 3 ppm (2 mg/m3), JAN1999
Occupational Exposure Limit - HUNGARY time-weighted average 0.5 mg/m3, short term exposure limit 1 mg/m3, JAN1993
Occupational Exposure Limit - JAPAN Occupational Exposure Limit 3 ppm (2.5 mg/m3), JAN1999
Occupational Exposure Limit - NORWAY time-weighted average 0.8 ppm (0.6 mg/m3), JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 3 ppm (2 mg/m3), JAN1993
Occupational Exposure Limit - POLAND MAC(time-weighted average) 0.5 mg/m3, MAC(short term exposure limit) 4 mg/m3, JAN1999
Occupational Exposure Limit - RUSSIA time-weighted average 3 ppm (0.1 mg/m3), short term exposure limit 0.5 mg/m3, JAN1993
Occupational Exposure Limit - SWEDEN CEILING 2 ppm (1.7 mg/m3), JAN1999
Occupational Exposure Limit - SWITZERLAND MAK- week 1.8 ppm (1.5 mg/m3), KZG- week 3.6 ppm (3.0 mg/m3), JAN1999
Occupational Exposure Limit - TURKEY time-weighted average 3 ppm (2 mg/m3), JAN1993
Occupational Exposure Limit - UNITED KINGDOM short term exposure limit 3 ppm (2.5 mg(F)/m3, SEP2000
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

ceiling concentration 3 ppm(F)
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
ceiling concentration 3 ppm(F)


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO HYDROGEN FLUORIDE-air 10 hour time-weighted average 3 ppm;
short term exposure limit 6 ppm 		NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 38550;
Number of Industries 97;
Total Number of Facilities 6,590;
Number of Occupations 68;
Total Number of Employees Exposed 68,886
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 38550;
Number of Industries 96;
Total Number of Facilities 11,332;
Number of Occupations 89;
Total Number of Employees Exposed 189,051;
Total Number of Female Employees Exposed 68,792


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
ATSDR TOXICOLOGY PROFILE (NTIS** PB/93/182566/AS)
EPA GENETOX PROGRAM 1988, Positive: D melanogaster Sex-linked lethal
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used in special metallurgical process, nuclear engineering, making of FLUORINE compounds
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Acids, inorganic, 7903
OSHA ANALYTICAL METHOD #ID110


REFERENCES:

CODEN
REFERENCE
34ZIAG "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958-
AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine. (Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU.
AMLTAS Annales de Medecine Legale et de Criminologie. (Paris, France) V.31-38, 1951-58. For publisher information, see MLDCAS.
AMRL** Aerospace Medical Research Laboratory Report. (Aerospace Technical Div., Air Force Systems Command, Wright-Patterson Air Force Base, OH 45433)
AMSSAQ Acta Medica Scandinavica, Supplement. (Almqvist & Wiksell, POB 45150, S-10430 Stockholm, Sweden) No.1-730, 1921-88.
ATENBP Atmospheric Environment. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1967-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
CRSBAW Comptes Rendus des Seances de la Societe de Biologie et de Ses Filiales. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1849-
CTOXAO Clinical Toxicology. (New York, NY) V.1-18, 1968-81. For publisher information, see JTCTDW.
CYGEDX Cytology and Genetics (English Translation). Translation of TGANAK. (Allerton Press Inc., 150 Fifth Ave., New York, NY 10011) V.8- 1974-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
FKIZA4 Fukuoka Igaku Zasshi. (c/o Kyushu Daigaku Igakubu, Tatekasu, Fukuoka-shi, Fukuoka, Japan) V.33- 1940-
FLUOA4 Fluoride. (International Soc. for Fluoride Research, Inc., POB 692, Warren, MI 48090) V.3- 1970-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
JCTODH Journal of Combustion Toxicology. (Westport, CT) V.3-9, 1976-82.
JIDHAN Journal of Industrial Hygiene. (Cambridge, MA) V.1-17, 1919-35. For publisher information, see AEHLAU.
JTCTDW Journal of Toxicology, Clinical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.19- 1982-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
SAIGBL Sangyo Igaku. Japanese Journal of Industrial Health. (Nippon Sangyo Eisei Igakkai, Kosu Eisei Bldg., 1-29-8, Shinjuku, Shinjuku-ku, Tokyo 160, Japan) V.1- 1959-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
VCVN5* "Vrednie chemichescie veshestva. Neorganicheskie soedinenia elementov V-VII groopp" (Hazardous substances. Inornanic substances containing V-VII group elements), Bandman A.L. et al., Chimia, 1989.

Used in special metallurgical process, nuclear engineering, making of FLUORINE compounds

NIOSH PROFILE (PETROLEUM REFINING), FIRL, 4/78

NIOSH PROFILE (SMELTERS, SECONDARY NON-FERROUS), SRI, 2/77

RTECS Compound Description:
   Mutagen
   Reproductive Effector
   Human Data
   Primary Irritant

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