The Registry of Toxic Effects of Chemical Substances

Hydrazobenzene

RTECS #: MW2625000

CAS #: 122-66-7

UPDATE: May 2005 MW: 184.26 MF: C12H12N2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. TUMORIGENIC DATA:
  4. NIOSH DOCUMENTATION AND SURVEILLANCE:
  5. STATUS IN FEDERAL AGENCIES:
  6. REFERENCES:

SYNONYMS:

  1. (sym) - Diphenylhydrazine
  2. 1,2 - Diphenylhydrazine
  3. 1,2 - Diphenylhydrazine (9CI)
  4. Benzene, hydrazodi -
  5. Hydrazine, 1,2 - diphenyl -
  1. Hydrazobenzen (Czech)
  2. N,N' - Bianiline
  3. N,N' - Diphenylhydrazine
  4. NCI - C01854
  5. RCRA waste number U109


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis hamster ovary 14 mg/L EMMUEG 10(Suppl 10),1,1987
DNA damage intraperitoneal
mouse 		75 mg/kg MUREAV 493,39,2001
DNA damage oral
mouse 		150 mg/kg MUREAV 493,39,2001
DNA inhibition intraperitoneal
mouse 		100 mg/kg MUREAV 46,305,1977
mutation in microorganisms Salmonella typhimurium 10 ng/plate (-enzymatic activation step) ENMUDM 7(Suppl 5),1,1985
sister chromatid exchange hamster ovary 5 mg/L EMMUEG 10(Suppl 10),1,1987


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lowest published toxic dose: 26 gm/kg/78 week- continuous Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors 		NCITR* NCI-TR-92,1978
oral
rat 		lowest published toxic dose: 2,620 mg/kg/78 week- continuous Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors

Skin and Appendages: Tumors 		NCITR* NCI-TR-92,1978
oral
rat 		toxic dose : 9,820 mg/kg/78 week- continuous Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors

Skin and Appendages: Tumors 		NCITR* NCI-TR-92,1978
oral
rat 		toxic dose : 36 gm/kg/53 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Skin and Appendages: Tumors

Reproductive: Tumorigenic effects: Uterine tumors 		VOONAW 20(4),53,1974
subcutaneous
mouse 		lowest published toxic dose: 8,400 mg/kg/38 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Liver: Tumors

Tumorigenic: Tumors at site of application 		VOONAW 20(4),53,1974
subcutaneous
rat 		lowest published toxic dose: 5,200 mg/kg/52 week- continuous Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors

Skin and Appendages: Tumors 		GTPZAB 19(6),28,1975
subcutaneous
rat 		toxic dose : 16 gm/kg/1 year- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Ear: Tumors 		CANCAR 3,789,1950
subcutaneous
rat 		toxic dose : 6 gm/kg/27 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Skin and Appendages: Tumors

Reproductive: Tumorigenic effects: Uterine tumors 		VOONAW 20(4),53,1974
skin
mouse 		lowest published toxic dose: 5,280 mg/kg/26 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Liver: Tumors 		VOONAW 20(4),53,1974


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X5870;
Number of Industries 1;
Total Number of Facilities 7;
Number of Occupations 1;
Total Number of Employees Exposed 977;
Total Number of Female Employees Exposed 154


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
ATSDR TOXICOLOGY PROFILE (NTIS** PB/91/180356/AS)
EPA GENETOX PROGRAM 1988, Positive: Carcinogenicity-mouse/rat
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Bioassay (feed);clear evidence:mouse,rat NCITR* NCI-TR-92,1978
NTP 11th Report on Carcinogens,2004:Reasonably anticipated to be a human carcinogen


REFERENCES:

CODEN
REFERENCE
CANCAR Cancer (Philadelphia). (Lippincott/Harper, Journal Fulfillment Dept., 2350 Virginia Ave., Hagerstown, MD 21740) V.1- 1948-
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG.
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NCITR* National Cancer Institute Carcinogenesis Technical Report Series. (Bethesda, MD) No.0-205. For publisher information, see NTPTR*.
VOONAW Voprosy Onkologii. Problems of Oncology. For English translation, see PONCAU. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-10, 1928-37; V.1- 1955-

RTECS Compound Description:
   Tumorigen
   Mutagen

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