The Registry of Toxic Effects of Chemical Substances

Hydrazine, phenyl -

RTECS #: MV8925000

CAS #: 100-63-0

UPDATE: May 2004 MW: 108.16 MF: C6H8N2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. TUMORIGENIC DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. REVIEWS:
  8. STANDARDS AND REGULATIONS:
  9. NIOSH DOCUMENTATION AND SURVEILLANCE:
  10. STATUS IN FEDERAL AGENCIES:
  11. REFERENCES:

SYNONYMS:

  1. Fenilidrazina (Italian)
  2. Fenylhydrazine (Dutch)
  3. Hydrazine - benzene
  4. Hydrazinobenzene
  1. Phenylhydrazin (German)
  2. Phenylhydrazine
  3. Phenylhydrazine (ACGIH:OSHA)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
DNA damage intraperitoneal
mouse 		350 µmol/kg CNREA8 41,1469,1981
DNA repair Escherichia coli 500 ng/well MUREAV 133,161,1984
mutation in microorganisms Escherichia coli 39,100 ng/plate (-enzymatic activation step) MUREAV 412,17,1998
mutation in microorganisms other microorganisms 150 µg/L (-enzymatic activation step) MUREAV 173,233,1986
mutation in microorganisms Salmonella typhimurium 4,600 nmol/plate (+/-enzymatic activation step) CNREA8 41,1469,1981
gene conversion and mitotic recombination Saccharomyes cerevisiae 25 mg/L MUREAV 308,159,1994


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
rat 		lowest published toxic dose: 30 mg/kg (17-19 day pregnant) Reproductive: Effects on newborn: Behavioral TJADAB 8,97,1973


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
subcutaneous
rat 		lowest published toxic dose: 5,200 mg/kg/52 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors

Skin and Appendages: Tumors 		GTPZAB 19(6),28,1975


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mouse 		lethal concentration (50 percent kill): 2,120 mg/m3 N/R TLSMA6 115,59,1977
inhalation
rat 		lethal concentration (50 percent kill): 2,610 mg/m3 N/R TLSMA6 115,59,1977
intraperitoneal
mouse 		lethal dose (50 percent kill): 170 mg/kg N/R CNREA8 41,1469,1981
intravenous
dog 		lowest published lethal dose: 120 mg/kg N/R XPHBAO 271,159,1941
oral
dog 		lowest published lethal dose: 200 mg/kg N/R XPHBAO 271,159,1941
oral
guinea pig 		lethal dose (50 percent kill): 80 mg/kg Behavioral: Excitement

Behavioral: Muscle contraction or spasticity 		HYSAAV 30(7-9),191,1965
oral
mouse 		lethal dose (50 percent kill): 175 mg/kg Behavioral: Convulsions or effect on seizure threshold

Behavioral: Change in motor activity (specific assay) 		GISAAA 30(8),21,1965
oral
rat 		lethal dose (50 percent kill): 188 mg/kg Behavioral: Excitement

Behavioral: Muscle contraction or spasticity 		HYSAAV 30(7-9),191,1965
oral
rabbit 		lethal dose (50 percent kill): 80 mg/kg Behavioral: Excitement

Behavioral: Muscle contraction or spasticity 		HYSAAV 30(7-9),191,1965
subcutaneous
mouse 		lowest published lethal dose: 170 mg/kg Lung, Thorax, or Respiration: Dyspnea

Lung, Thorax, or Respiration: Cyanosis

Lung, Thorax, or Respiration: Other changes 		JIHTAB 18,1,1936
skin
rabbit 		lowest published lethal dose: 90 mg/kg Lung, Thorax, or Respiration: Cyanosis

Lung, Thorax, or Respiration: Respiratory stimulation

Kidney, Ureter, and Bladder: Hematuria 		NTIS** OTS0546542
unreported route
frog 		lowest published lethal dose: 300 mg/kg N/R XPHBAO 271,159,1941


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
rat 		lowest published toxic dose: 150 mg/kg/3 day- intermittent Blood: Pigmented or nucleated red blood cells

Blood: Changes in bone marrow not included in above

Blood: Changes in erythrocyte (RBC) count 		JJATDK 20,25,2000
intraperitoneal
rat 		lowest published toxic dose: 100 mg/kg/2 day- intermittent Blood: Normocytic anemia

Blood: Changes in other cell count (unspecified)

Blood: Changes in leukocyte (WBC) count 		JAPTO* 20,25,2000
intraperitoneal
rat 		lowest published toxic dose: 150 mg/kg/3 day- intermittent Blood: Changes in bone marrow not included in above JAPTO* 20,25,2000
subcutaneous
rat 		lowest published toxic dose: 70 mg/kg/7 day- intermittent Blood: Changes in bone marrow not included in above

Blood: Changes in erythrocyte (RBC) count

Blood: Changes in platelet count 		JTSCDR 20,1,1995


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.1 ppm (skin) DTLVS* TLV/BEI,2003
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Confirmed Animal Carcinogen with Unknown DTLVS* TLV/BEI,2003


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 5 ppm (22 mg/m3) (skin) DTLVS* 3,207,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 5 ppm (22 mg/m3) (skin) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 5 ppm (22 mg/m3) (skin) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 5 ppm (22 mg/m3) (skin) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 5 ppm (22 mg/m3) (skin) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - ARAB Republic of Egypt time-weighted average 5 ppm (20 mg/m3), Skin, JAN1993
Occupational Exposure Limit - AUSTRALIA time-weighted average 5 ppm (20 mg/m3), short term exposure limit 10 ppm, Skin, Carcinogen, JAN1993
Occupational Exposure Limit - AUSTRIA MAK 5 ppm (22 mg/m3), Skin, Suspected Carcinogen, JAN1999
Occupational Exposure Limit - BELGIUM time-weighted average 5 ppm (22 mg/m3), short term exposure limit 10 ppm, Skin, Carcinogen, JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 0.1 ppm (0.6 mg/m3), Skin, JAN1999
Occupational Exposure Limit - FINLAND short term exposure limit 5 ppm (22 mg/m3), Skin, JAN1999
Occupational Exposure Limit - GERMANY MAK 5 ppm (22 mg/m3), Skin, Carcinogen, JAN1999
Occupational Exposure Limit - NORWAY time-weighted average 0.6 mg/m3, JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 5 ppm (22 mg/m3), JAN1993
Occupational Exposure Limit - POLAND MAC(time-weighted average) 20 mg/m3, JAN1999
Occupational Exposure Limit - SWITZERLAND MAK- week 5 ppm (22 mg/m3), Skin, JAN1999
Occupational Exposure Limit - TURKEY time-weighted average 5 ppm (22 mg/m3), Skin, JAN1993
Occupational Exposure Limit - UNITED KINGDOM CHAN, SEP2000
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Confirmed Animal Carcinogen with Unknown
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Confirmed Animal Carcinogen with Unknown


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO HYDRAZINES-air Carcinogen ceiling concentration 0.03 ppm/120 minute NIOSH* DHHS #92-100,1992
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO PHENYLHYDRAZINE-air Carcinogen ceiling concentration 0.14 ppm/120 minute (Sk) NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 57300;
Number of Industries 2;
Total Number of Facilities 56;
Number of Occupations 5;
Total Number of Employees Exposed 1,120
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 57300;
Number of Industries 2;
Total Number of Facilities 10;
Number of Occupations 7;
Total Number of Employees Exposed 212;
Total Number of Female Employees Exposed 19


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as a reagent in chemical analysis and organic synthesis
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Phenyl hydrazine, 3518


REFERENCES:

CODEN
REFERENCE
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
HYSAAV Hygiene and Sanitation (USSR). English translation of GISAAA. (Springfield, VA) 1964-71. Discontinued.
JAPTO* Journal of Applied Toxicology (John Wiley & Sons, Ltd., Oldlands Way Bognor Regis West Sussex, PO22 9SA England) V.1- 1981-
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU.
JJATDK JAT, Journal of Applied Toxicology. (John Wiley & Sons Ltd., Baffins Lane, Chichester, W. Sussex PO19 1UD, UK) V.1- 1981-
JTSCDR Journal of Toxicological Sciences. (Japanese Soc. of Toxicological Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku, Tokyo 113, Japan) V.1- 1976-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968-
TLSMA6 Trudy Leningradskogo Sanitarno-Gigienicheskogo Meditsinskogo Instituta. (Leningrad, Russia) V.1-145, 1949-82. Discontinued.
XPHBAO U.S. Public Health Service, Public Health Bulletin. (Washington, DC)

Used as a reagent in chemical analysis and organic synthesis

RTECS Compound Description:
   Tumorigen
   Mutagen
   Reproductive Effector

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