The Registry of Toxic Effects of Chemical Substances

Hydrazine, methyl -

RTECS #: MV5600000

CAS #: 60-34-4

UPDATE: November 2004 MW: 46.09 MF: CH6N2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. TUMORIGENIC DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. REVIEWS:
  8. STANDARDS AND REGULATIONS:
  9. NIOSH DOCUMENTATION AND SURVEILLANCE:
  10. STATUS IN FEDERAL AGENCIES:
  11. REFERENCES:

SYNONYMS:

  1. 1 - Methylhydrazine
  2. MMH
  3. Methyl hydrazine
  4. Methylhydrazine (ACGIH:OSHA)
  1. Metylohydrazyna (Polish)
  2. Monomethylhydrazine (OSHA)
  3. RCRA waste number P068


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
dominant lethal test intraperitoneal
rat 		1,075 mg/kg/5 day- intermittent NTIS** AD-A041-973
DNA adduct human fibroblast 116 pmol NTIS** AD-A092-249
DNA inhibition mouse Ascites tumor 581 µmol/L JJATDK 1,243,1981
unscheduled DNA synthesis hamster ovary 1 µmol/L NTIS** AD-A075-605
unscheduled DNA synthesis hamster lung 1 µmol/L NTIS** AD-A075-605
unscheduled DNA synthesis rat lung 1 µmol/L NTIS** AD-A075-605
mutation in microorganisms Escherichia coli 500 nmol/disc (-enzymatic activation step) MUREAV 71,269,1980
mutation in microorganisms Salmonella typhimurium 10 µmol/plate (+enzymatic activation step) MUREAV 54,167,1978
mutation in microorganisms Salmonella typhimurium 1 µL/plate (-enzymatic activation step) NTIS** AD-A041-973
other mutation test systems mouse Ascites tumor 758 µmol/L JJATDK 1,243,1981


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
rat 		lowest published toxic dose: 100 mg/kg (6-15 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) APTOD9 19,A21,1980
intraperitoneal
rat 		lowest published toxic dose: 50 mg/kg (6-15 day pregnant) Reproductive: Specific developmental abnormalities: Eye, ear APTOD9 19,A21,1980
intravenous
rat 		lowest published toxic dose: 24 mg/kg (6-13 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Other effects to embryo or fetus 		FACOEB 10,391,1993
intravenous
rat 		lowest published toxic dose: 33,600 µg/kg (6-13 day pregnant) Reproductive: Effects on fertility: Female fertility index (e.g., # females pregnant per # sperm positive females; # females pregnant per # females mated) FACOEB 10,391,1993
oral
rat 		lowest published toxic dose: 5 mg/kg (6 day pregnant) Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea) FACOEB 10,391,1993


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
hamster 		lowest published toxic concentration: 5 ppm/6 hour/1 year- intermittent Tumorigenic: Neoplastic by RTECS criteria

Olfaction: Tumors

Endocrine: Adrenal cortex hyperplasia 		NTIS** AD-A154-659
inhalation
mouse 		lowest published toxic concentration: 2 ppm/6 hour/1 year- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors 		NTIS** AD-A154-659
inhalation
rat 		lowest published toxic concentration: 20 ppb/6 hour/1 year- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Blood: Leukemia 		NTIS** AD-A154-659
intraperitoneal
mouse 		lowest published toxic dose: 72 mg/kg/8 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors 		JNCIAM 42,337,1969
oral
hamster 		lowest published toxic dose: 3,000 mg/kg/47 week- continuous Tumorigenic: Carcinogenic by RTECS criteria

Gastrointestinal: Colon tumors

Liver: Tumors 		CNREA8 33,2744,1973
oral
hamster 		toxic dose : 5,768 mg/kg/2 year- continuous Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Liver: Tumors 		AJPAA4 70,102,1973
oral
mouse 		lowest published toxic dose: 10 gm/kg/1 year- continuous Tumorigenic: Neoplastic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Blood: Lymphoma including Hodgkin's disease 		IJCNAW 9,109,1972


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
dog 		lethal concentration (50 percent kill): 96 ppm/1 hour N/R AIHAAP 31,667,1970
inhalation
guinea pig 		lethal concentration (50 percent kill): 270 mg/m3/4 hour Brain and Coverings: Other degenerative changes

Lung, Thorax, or Respiration: Acute pulmonary edema

Liver: Liver function tests impaired 		STGNBT -,163,1999
inhalation
hamster 		lethal concentration (50 percent kill): 143 ppm/4 hour Behavioral: Convulsions or effect on seizure threshold AMIHAB 12,609,1955
inhalation
monkey 		lethal concentration (50 percent kill): 82 ppm/1 hour Eye: Conjunctiva irritation

Gastrointestinal: Nausea or vomiting

Behavioral: Convulsions or effect on seizure threshold 		AIHAAP 31,667,1970
inhalation
mouse 		lethal concentration (50 percent kill): 56 ppm/4 hour Eye: Other eye effects

Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Dyspnea 		AMIHAB 12,609,1955
inhalation
rat 		lethal concentration (50 percent kill): 34 ppm/4 hour N/R AMRL** TR-67-137,1967
intraperitoneal
hamster 		lethal dose (50 percent kill): 21 mg/kg N/R CTOXAO 4,435,1971
intraperitoneal
mouse 		lethal dose (50 percent kill): 15 mg/kg Eye: Miosis (pupilliary constriction)

Behavioral: Convulsions or effect on seizure threshold

Skin and Appendages: Other: Hair 		PSEBAA 124,172,1967
intraperitoneal
rat 		lethal dose (50 percent kill): 21 mg/kg N/R CTOXAO 4,435,1971
intravenous
dog 		lethal dose (50 percent kill): 12 mg/kg Blood: Methemoglobinemia- Carboxhemoglobinemia PSEBAA 131,226,1969
intravenous
mouse 		lethal dose (50 percent kill): 33,200 µg/kg N/R MEPAAX 24,71,1973
intravenous
rat 		lethal dose (50 percent kill): 17 mg/kg N/R CTOXAO 4,435,1971
intravenous
rabbit 		lethal dose (50 percent kill): 12 mg/kg Blood: Methemoglobinemia- Carboxhemoglobinemia PSEBAA 131,226,1969
oral
hamster 		lethal dose (50 percent kill): 22 mg/kg N/R CTOXAO 4,435,1971
oral
mouse 		lethal dose (50 percent kill): 29 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold

Behavioral: Excitement 		NTIS** AD-A125-539
oral
rat 		lethal dose (50 percent kill): 32 mg/kg Behavioral: Convulsions or effect on seizure threshold XAWPA2 CWL 2-10,1958
subcutaneous
mouse 		lethal dose (50 percent kill): 25 mg/kg N/R BJCAAI 30,429,1974
subcutaneous
rat 		lethal dose (50 percent kill): 35 mg/kg N/R BJCAAI 30,429,1974
skin
guinea pig 		lethal dose (50 percent kill): 48 mg/kg Blood: Methemoglobinemia- Carboxhemoglobinemia PSEBAA 131,226,1969
skin
hamster 		lethal dose (50 percent kill): 239 mg/kg N/R CTOXAO 4,435,1971
skin
rat 		lethal dose (50 percent kill): 183 mg/kg N/R CTOXAO 4,435,1971
skin
rabbit 		lethal dose (50 percent kill): 95 mg/kg Blood: Methemoglobinemia- Carboxhemoglobinemia PSEBAA 131,226,1969


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
dog 		lowest published toxic concentration: 200 ppb/24 hour/30 week- continuous Blood: Methemoglobinemia- Carboxhemoglobinemia

Nutritional and Gross Metabolic: Changes in: P

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases 		NTIS** AD734-543
inhalation
dog 		lowest published toxic concentration: 200 ppb/24 hour/26 week- continuous Blood: Changes in bone marrow not included in above

Blood: Changes in erythrocyte (RBC) count

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases 		NTIS** AD-751440
inhalation
monkey 		lowest published toxic concentration: 5 ppm/6 hour/26 week- intermittent Blood: Other changes NTIS** AD-751440
inhalation
mouse 		lowest published toxic concentration: 5 ppm/6 hour/26 week- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field NTIS** AD-751440
inhalation
rat 		lowest published toxic concentration: 200 ppb/24 hour/26 week- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain NTIS** AD-751440


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.01 ppm (skin) DTLVS* TLV/BEI,2003
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Confirmed Animal Carcinogen with Unknown DTLVS* TLV/BEI,2003
TOXICOLOGY REVIEW
MUREAV 39,111,1977
TOXICOLOGY REVIEW
ARVPAX 5,447,1965


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Mine Safety and Health Administration (MSHA) STANDARD air-ceiling concentration 0.2 ppm (0.35 mg/m3) (skin) DTLVS* 3,174,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) ceiling concentration 0.2 ppm (0.35 mg/m3) (skin) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) ceiling concentration 0.2 ppm (0.35 mg/m3) (skin) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) ceiling concentration 0.2 ppm (0.35 mg/m3) (skin) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) ceiling concentration 0.2 ppm (0.35 mg/m3) (skin) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 0.2 ppm (0.35 mg/m3), Skin, Carcinogen, JAN1993
Occupational Exposure Limit - BELGIUM short term exposure limit 0.2.. ppm (0.38 mg/m3), Skin, Carcinogen JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 0.04 ppm (0.08 mg/m3), Skin, JAN1999
Occupational Exposure Limit - FINLAND short term exposure limit 0.2 ppm (0.35 mg/m3), Skin, JAN1999
Occupational Exposure Limit - FRANCE VME 0.2 ppm (0.35 mg/m3), JAN1999
Occupational Exposure Limit - GERMANY No MAK Established, JAN1999
Occupational Exposure Limit - NORWAY time-weighted average 0.08 mg/m3, JAN1999
Occupational Exposure Limit - THE NETHERLANDS MAC- continuous 0.35 mg/m3, Skin, 2003
Occupational Exposure Limit - POLAND MAC(time-weighted average) 0.02 mg/m3, MAC(short term exposure limit) 0.1 mg/m3, JAN1999
Occupational Exposure Limit - SWITZERLAND MAK- week 0.2 ppm (0.35 mg/m3), Skin, JAN1999
Occupational Exposure Limit - THAILAND time-weighted average 0.2 ppm (0.35 mg/m3), JAN1993
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Confirmed Animal Carcinogen with Unknown
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Confirmed Animal Carcinogen with Unknown


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO METHYLHYDRAZINE-air Carcinogen ceiling concentration 0.04 ppm/120 minute NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X4272;
Number of Industries 1;
Total Number of Facilities 14;
Number of Occupations 2;
Total Number of Employees Exposed 1,473;
Total Number of Female Employees Exposed 230


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Positive: Histidine reversion-Ames test; TRP reversion
EPA GENETOX PROGRAM 1988, Positive/limited: Carcinogenicity-mouse/rat
EPA GENETOX PROGRAM 1988, Negative: Rodent dominant lethal; In vitro UDS-human fibroblast
EPA GENETOX PROGRAM 1988, Negative: S cerevisiae gene conversion
EPA TSCA Section 8(b) CHEMICAL INVENTORY
used as an industrial chemical and chemical intermediate
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Monomethylhydrazine, 3510


REFERENCES:

CODEN
REFERENCE
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958-
AJPAA4 American Journal of Pathology. (Lippincott/Harper, Journal Fulfillment Dept., 2350 Virginia Ave., Hagerstown, MD 21740) V.1- 1925-
AMIHAB AMA Archives of Industrial Health. (Chicago, IL) V.11-21, 1955-60. For publisher information, see AEHLAU.
AMRL** Aerospace Medical Research Laboratory Report. (Aerospace Technical Div., Air Force Systems Command, Wright-Patterson Air Force Base, OH 45433)
APTOD9 Abstracts of Papers, Society of Toxicology. Annual Meetings. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802)
ARVPAX Annual Review of Pharmacology. (Palo Alto, CA) V.1-15, 1961-75. For publisher information, see ARPTDI.
BJCAAI British Journal of Cancer. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants. RG21 2XS, UK) V.1- 1947-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941-
CTOXAO Clinical Toxicology. (New York, NY) V.1-18, 1968-81. For publisher information, see JTCTDW.
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
FACOEB Food Additives and Contaminants. (Taylor & Francis Inc., 242 Cherry St., Philadelphia, PA 19106) V.1- 1984-
IJCNAW International Journal of Cancer. (International Union Against Cancer, 3 rue du Conseil- General, 1205 Geneva, Switzerland) V.1- 1966-
JJATDK JAT, Journal of Applied Toxicology. (John Wiley & Sons Ltd., Baffins Lane, Chichester, W. Sussex PO19 1UD, UK) V.1- 1981-
JNCIAM Journal of the National Cancer Institute. (Washington, DC) V.1-60, 1940-78. For publisher information, see JJIND8.
MEPAAX Medycyna Pracy. Industrial Medicine. (Ars-Polona, POB 1001, 00-068 Warsaw 1, Poland) V.1- 1950-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04-
STGNBT "Spravochnik po Toksikologii i Gigienicheskim Normativam (PDK) Potentsial'no Opasnykh Khimicheskikh Veshchestv" Kushneva, V.S., and R.B. Gorshkova, eds. 46, Zhivopisnaya St., 123182, Moscow, Russia, IzdAT 1999
XAWPA2 U.S. Army Chemical Warfare Laboratories. (Army Chemical Center, MD)

used as an industrial chemical and chemical intermediate

RTECS Compound Description:
   Tumorigen
   Mutagen
   Reproductive Effector

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