The Registry of Toxic Effects of Chemical Substances
Hydracrylonitrile RTECS #: MU5250000
CAS #: 109-78-4
The Registry of Toxic Effects of Chemical Substances
Hydracrylonitrile |
| UPDATE: July 2000 | MW: 71.09 | MF: C3H5NO |
SYNONYMS:
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SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
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| EFFECT
REFERENCE
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eye | rabbit
500 mg
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moderate
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AJOPAA 29,1363,1946
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skin | rabbit
10 mg/24 hour open irritation test
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moderate
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JIHTAB 26,269,1944
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skin | rabbit
520 mg open irritation test
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mild
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UCDS** 8/18/1967
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MUTATION DATA AND REFERENCES:
SYSTEM TEST
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ROUTE/ | ORGANISM/ TISSUE
DOSE
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REFERENCE
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N/R
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N/R
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N/R
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N/R
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REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
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| EFFECT
REFERENCE
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N/R |
N/R
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N/R
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N/R
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TUMORIGENIC DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
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| EFFECT
REFERENCE
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N/R |
N/R
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N/R
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N/R
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ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
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| EFFECT
REFERENCE
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inhalation | mouse
lethal concentration (33 percent kill): 300 mg/m3/2 hour
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N/R
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85GMAT -,66,1982
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intraperitoneal | mouse
lethal dose (50 percent kill): 500 mg/kg
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N/R
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NTIS** AD277-689
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intraperitoneal | rat
lethal dose (50 percent kill): 3,200 mg/kg
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N/R
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38MKAJ 2C,4875,1982
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oral | mouse
lethal dose (50 percent kill): 1,800 mg/kg
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N/R
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AMIHBC 8,371,1953
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oral | rat
lethal dose (50 percent kill): 3,200 mg/kg
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N/R
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38MKAJ 2C,4875,1982
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oral | rabbit
lowest published lethal dose: 900 mg/kg
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N/R
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AMIHBC 8,371,1953
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skin | rabbit
lethal dose (50 percent kill): 5 mL/kg
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N/R
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UCDS** 8/18/1967
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OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
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| EFFECT
REFERENCE
|
oral | rat
lowest published toxic dose: 8,100 mg/kg/90 day- continuous
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Brain and Coverings: Changes in brain weight | Cardiac: Changes in heart weight
JTEHD6 2,31,1976
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REVIEWS:
ORGANIZATION
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STANDARD
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REFERENCE
N/R
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N/R
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N/R
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STANDARDS AND REGULATIONS:
ORGANIZATION
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STANDARD
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REFERENCE
Occupational Exposure Limit - RUSSIA
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short term exposure limit 100 mg/m3, JAN1993
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NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION
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STANDARD or SURVEY
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REFERENCE
National Occupational Exposure Survey 1983
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National Occupational Exposure Survey 1983: Hazard Code: E0469 |
 ;Number of Industries 1; Total Number of Facilities 4; Number of Occupations 3; Total Number of Employees Exposed 348; Total Number of Female Employees Exposed 30 | |||
STATUS IN FEDERAL AGENCIES:
ORGANIZATION
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REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
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Used as a solvent for some cellulose esters and many inorganic salts
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EPA TSCA Section 8(d) unpublished health/safety studies
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EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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REFERENCES:
CODEN
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REFERENCE
38MKAJ
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"Patty's Industrial Hygiene and Toxicology," 3rd rev. ed., Clayton, G.D., and F.E. Clayton,
eds., New York, John Wiley & Sons, Inc., 1978-82. Vol. 3 originally pub. in 1979; pub. as 2nd
rev. ed. in 1985.
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85GMAT
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"Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F.,
et al., Moscow, Centre of International Projects, GKNT, 1982
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AJOPAA
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American Journal of Ophthalmology. (Ophthalmic Pub. Co., 435 N. Michigan Ave., Suite 1415,
Chicago, IL 60611) Series 3: V.1- 1918-
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AMIHBC
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AMA Archives of Industrial Hygiene and Occupational Medicine. (Chicago, IL) V.2-10, 1950-54.
For publisher information, see AEHLAU.
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JIHTAB
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Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For
publisher information, see AEHLAU.
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JTEHD6
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Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW,
Washington, DC 20005) V.1- 1975/76-
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NTIS**
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National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse
for Scientific & Technical Information.
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UCDS**
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Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817)
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