The Registry of Toxic Effects of Chemical Substances

1 - Hexanol, 2 - ethyl - , phosphate

RTECS #: MP0770000

CAS #: 78-42-2

UPDATE: November 2004 MW: 434.72 MF: C24H51O4P


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. TUMORIGENIC DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. REVIEWS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. 2 - Ethyl - 1 - hexanol phosphate
  2. Disflamoll TOF
  3. Flexol TOF
  4. Kronitex TOF
  5. Kronitexreg
  6. NCI - C54751
  7. Phosphoric acid tri (2 - ethylhexyl) ester
  1. Phosphoric acid, tris (2 - ethylhexyl) ester
  2. TOF
  3. Tri (2 - ethylhexyl) phosphate
  4. Triethylhexyl phosphate
  5. Trioctyl phosphate
  6. Tris (2 - ethylhexyl) phosphate
  7. Tris - (2 - ethylhexyl) fosfat (Czech)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		500 mg mild AJOPAA 29,1363,1946
skin
rabbit 		250 mg moderate 34ZIAG -,606,1969


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
morphological transform mouse fibroblast 0.1 mg/L/21 day (-enzymatic activation step) EMMUEG 37,231,2001


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lowest published toxic dose: 520 gm/kg/2 year- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors 		EVHPAZ 65,271,1986
oral
mouse 		lowest published toxic dose: 257,500 mg/kg/103 week- intermittent Tumorigenic: Neoplastic by RTECS criteria

Endocrine: Thyroid tumors 		NTIS** PB85-171502/AS
oral
mouse 		lowest published toxic dose: 515,000 mg/kg/103 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors 		NTIS** PB85-171502/AS
oral
rat 		lowest published toxic dose: 1,030,000 mg/kg/103 week- intermittent Tumorigenic: Neoplastic by RTECS criteria

Endocrine: Adrenal cortex tumors 		NTIS** PB85-171502/AS


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
guinea pig 		lethal concentration (50 percent kill): 450 mg/m3/30 minute N/R 85JCAE -,1133,1986
intraperitoneal
mouse 		lethal dose (50 percent kill): 3,200 mg/kg N/R NTIS** OTS0528341
intraperitoneal
rat 		lethal dose (50 percent kill): 30 gm/kg N/R NTIS** OTS0528341
oral
mammal (species unspecified) 		lethal dose (50 percent kill): 7,600 mg/kg N/R GISAAA 39(4),86,1974
oral
mouse 		lethal dose (50 percent kill): 12,800 mg/kg N/R NTIS** OTS0528341
oral
rat 		lethal dose (50 percent kill): 37 gm/kg N/R JIHTAB 30,63,1948
oral
rabbit 		lethal dose (50 percent kill): 46 gm/kg N/R 85JCAE -,1133,1986
skin
rabbit 		lethal dose (50 percent kill): 20 gm/kg N/R 85JCAE -,1133,1986
unreported route
rat 		lethal dose (50 percent kill): 40 gm/kg N/R 29ZWAE -,337,1968


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lowest published toxic dose: 32,500 mg/kg/13 week- intermittent Gastrointestinal: Other changes NTPTR* NTP-TR-274,1984
oral
mouse 		lowest published toxic dose: 10,080 mg/kg/14 day- continuous Behavioral: Somnolence (general depressed activity)

Skin and Appendages: Other: Hair 		NTPTR* NTP-TR-274,1984
oral
rat 		lowest published toxic dose: 18,900 mg/kg/9 week- continuous Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in bladder weight

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) 		TOLED5 13,29,1982
oral
rat 		lowest published toxic dose: 46,500 mg/kg/30 day- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain NTIS** OTS0528359
oral
rat 		lowest published toxic dose: 4,200 mg/kg/14 day- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain NTPTR* NTP-TR-274,1984


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
TOXICOLOGY REVIEW
MUREAV 543,201,2003


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 80228;
Number of Industries 6;
Total Number of Facilities 108;
Number of Occupations 22;
Total Number of Employees Exposed 3,565
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 80228;
Number of Industries 1;
Total Number of Facilities 40;
Number of Occupations 1;
Total Number of Employees Exposed 1,209;
Total Number of Female Employees Exposed 725


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as a pharmaceutical and veterinary drug
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NTP Carcinogenesis Studies (gavage);some evidence:mouse NTPTR* NTP-TR-274,1984
NCI Carcinogenesis Studies (gavage);equivocal evidence:mouse,rat


REFERENCES:

CODEN
REFERENCE
29ZWAE "Practical Toxicology of Plastics," Lefaux, R., Cleveland, OH, Chemical Rubber Co., 1968
34ZIAG "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
AJOPAA American Journal of Ophthalmology. (Ophthalmic Pub. Co., 435 N. Michigan Ave., Suite 1415, Chicago, IL 60611) Series 3: V.1- 1918-
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing Office, Supt of Documents, Washington, DC 20402) No.1- 1972-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU.
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206-
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-

Used as a pharmaceutical and veterinary drug

RTECS Compound Description:
   Tumorigen
   Mutagen
   Primary Irritant

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