The Registry of Toxic Effects of Chemical Substances

2 - Hexanone, 5 - methyl -

RTECS #: MP3850000

CAS #: 110-12-3

UPDATE: November 2004 MW: 114.21 MF: C7H14O


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. 2 - Methyl - 5 - hexanone
  2. 5 - Methyl - 2 - hexanone
  3. Isoamyl methyl ketone
  4. Isopentyl methyl ketone
  5. Ketone, methyl isoamyl
  1. MIAK
  2. Methyl isoamyl ketone
  3. Methyl isoamyl ketone (ACGIH:OSHA)
  4. Methyl isopentyl ketone


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		100 µL/24 hour mild NTIS** OTS0535379


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lethal concentration (50 percent kill): 3,813 ppm/6 hour Cardiac: Other changes

Lung, Thorax, or Respiration: Respiratory depression

Lung, Thorax, or Respiration: Other changes 		NTIS** OTS0535379
intraperitoneal
mouse 		lethal dose (50 percent kill): 800 mg/kg Cardiac: Other changes

Lung, Thorax, or Respiration: Other changes 		NTIS** OTS0535379
intraperitoneal
rat 		lowest published lethal dose: 400 mg/kg Cardiac: Other changes

Lung, Thorax, or Respiration: Other changes 		NTIS** OTS0535379
oral
mouse 		lethal dose (50 percent kill): 2,542 mg/kg N/R TOLED5 30,13,1986
oral
rat 		lethal dose (50 percent kill): 3,200 mg/kg Cardiac: Other changes

Lung, Thorax, or Respiration: Other changes 		NTIS** OTS0535379
skin
guinea pig 		lethal dose : >20 mL/kg Cardiac: Other changes

Lung, Thorax, or Respiration: Other changes 		NTIS** OTS0535379
skin
rabbit 		lethal dose (50 percent kill): 10 mL/kg N/R UCDS** 8/7/1963


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published toxic concentration: 1,000 ppm/6 hour/16 day- intermittent Liver: Changes in liver weight FAATDF 6,498,1986
inhalation
rat 		lowest published toxic concentration: 1,000 ppm/6 hour/96 day- intermittent Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in bladder weight 		FAATDF 6,498,1986
oral
rat 		lowest published toxic dose: 30 gm/kg/3 week- intermittent Liver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		NTIS** OTS0571116
oral
rat 		lowest published toxic dose: 130 gm/kg/13 week- intermittent Liver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases 		NTIS** OTS0571116


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 50 ppm DTLVS* TLV/BEI,2003


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 100 ppm (475 mg/m3) DTLWS* 3,22,1973
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 100 ppm (475 mg/m3) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 100 ppm (475 mg/m3) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 100 ppm (475 mg/m3) CFRGBR 29,1915.1000,1993
Occupational Exposure Limit - AUSTRALIA time-weighted average 50 ppm (240 mg/m3), JAN1993
Occupational Exposure Limit - BELGIUM time-weighted average 50 ppm (234 mg/m3), JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 50 ppm (230 mg/m3), JAN1999
Occupational Exposure Limit - FINLAND time-weighted average 50 ppm (230 mg/m3), short term exposure limit 75 ppm (350 mg/m3), JAN1999
Occupational Exposure Limit - FRANCE VME 50 ppm (240 mg/m3), JAN1999
Occupational Exposure Limit - NORWAY time-weighted average 25 ppm (115 mg/m3), JAN1999
Occupational Exposure Limit - SWEDEN time-weighted average 25 ppm (120 mg/m3), short term exposure limit 50 ppm (250 mg/m3), JAN1999
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 233 mg/m3, 2003
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 50 ppm (237 mg/m3), short term exposure limit 100 ppm, Skin, SEP2000
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 50 ppm
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 50 ppm


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO METHYL ISOAMYL KETONE-air 10 hour time-weighted average 50 ppm NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: M0430;
Number of Industries 44;
Total Number of Facilities 3,003;
Number of Occupations 36;
Total Number of Employees Exposed 25,307
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: M0430;
Number of Industries 17;
Total Number of Facilities 1,132;
Number of Occupations 22;
Total Number of Employees Exposed 18,834;
Total Number of Female Employees Exposed 4,071


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as a solvent
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
DTLWS* "Documentation of the Threshold Limit Values for Substances in Workroom Air," Supplements. For publisher information, see 85INA8.
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information, see TOSCF2
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817)

Used as a solvent

RTECS Compound Description:
   Agricultural Chemical
   Primary Irritant

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