The Registry of Toxic Effects of Chemical Substances

Hexane, 1,6 - diisocyanato -

RTECS #: MO1740000

CAS #: 822-06-0

UPDATE: February 2005 MW: 168.22 MF: C8H12N2O2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. ACUTE TOXICITY DATA:
  3. OTHER MULTIPLE DOSE DATA:
  4. REVIEWS:
  5. STANDARDS AND REGULATIONS:
  6. NIOSH DOCUMENTATION AND SURVEILLANCE:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. 1,6 - Diisocyanatohexane
  2. 1,6 - Hexamethylene diisocyanate
  3. 1,6 - Hexanediol diisocyanate
  4. Desmodur H
  5. Desmodur N
  6. HDI
  7. HDI - IC
  8. HMDI
  9. Hexamethylendiisokyanat (Czech)
  1. Hexamethylene diisocyanate
  2. Hexamethylene diisocyanate (ACGIH)
  3. Hexamethylene - 1,6 - diisocyanate
  4. Isocyanic acid, diester with 1,6 - hexanediol
  5. Isocyanic acid, hexamethylene ester
  6. Metyleno - bis - fenyloizocyjanian (Polish)
  7. Szesciometylenodwuizocyjanian (Polish)
  8. TL 78


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mouse 		lethal concentration (50 percent kill): 30 mg/m3 N/R 85GMAT -,74,1982
inhalation
rat 		lowest published lethal concentration: 60 mg/m3/4 hour Eye: Lacrimation

Lung, Thorax, or Respiration: Dyspnea

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		GTPZAB 12(10),40,1968
inhalation
rat 		lethal concentration (50 percent kill): 124 mg/m3/4 hour N/R TOSCF2 58,173,2000
inhalation
rat 		lethal concentration (50 percent kill): 462 mg/m3/4 hour Lung, Thorax, or Respiration: Changes in lung weight

Biochemical: Metabolism (intermediary): Other proteins 		TOSCF2 58,173,2000
inhalation
rat 		lowest published toxic concentration: 15.9 mg/m3/6 hour Lung, Thorax, or Respiration: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		TOSCF2 58,173,2000
inhalation
rat 		lowest published toxic concentration: 54.3 mg/m3/6 hour Lung, Thorax, or Respiration: Consolidation

Lung, Thorax, or Respiration: Acute pulmonary edema

Lung, Thorax, or Respiration: Pleural effusion 		TOSCF2 58,173,2000
inhalation
rat 		lowest published toxic concentration: 118.1 mg/m3/6 hour N/R TOSCF2 58,173,2000
intravenous
mouse 		lethal dose (50 percent kill): 5,600 µg/kg N/R CSLNX* NX#07805
oral
mouse 		lethal dose (50 percent kill): 350 mg/kg N/R TAKHAA 39,202,1980
oral
rat 		lethal dose (50 percent kill): 710 µL/kg N/R AIHAAP 30,470,1969
skin
rabbit 		lethal dose (50 percent kill): 570 µL/kg N/R AIHAAP 30,470,1969


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
guinea pig 		lowest published toxic concentration: 1 ppm/6 hour/5 day- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field NTIS** OTS0571057
inhalation
mouse 		lowest published toxic concentration: 300 ppb/6 hour/5 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		NTIS** OTS0571057
inhalation
rat 		lowest published toxic concentration: 50 ppb/6 hour/30 day- intermittent Olfaction: Other olfaction effects REPTED 14,135,2000
inhalation
rat 		lowest published toxic concentration: 2 ppm/6 hour/5 day- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field NTIS** OTS0571057
inhalation
rat 		lowest published toxic concentration: 40 ppb/6 hour/13 week- intermittent Olfaction: Other olfaction effects

Eye: Conjunctiva irritation 		NTIS** OTS0532755
inhalation
rat 		lowest published toxic concentration: 30 ppm/4 hour/2 week- intermittent Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Lung, Thorax, or Respiration: Dyspnea 		NTIS** OTS0555659
inhalation
rat 		lowest published toxic concentration: 0.5 ppm/6 hour/28 day- intermittent Olfaction: Other olfaction effects REPTED 14,135,2000
inhalation
rat 		lowest published toxic concentration: 0.5 ppm/6 hour/47 day- intermittent Olfaction: Other olfaction effects REPTED 14,135,2000
inhalation
rat 		lowest published toxic concentration: 0.5 ppm/20 day- continuous Olfaction: Other olfaction effects TJADAB 162,205,2000
oral
rat 		lowest published toxic dose: 3 gm/kg/2 week- intermittent Gastrointestinal: Changes in structure or function of salivary glands

Gastrointestinal: Hypermotility, diarrhea

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		NTIS** OTS0555659


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.005 ppm DTLVS* TLV/BEI,2003
TOXICOLOGY REVIEW
TOLED5 140-141,213,2003


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Exposure Limit - BELGIUM time-weighted average 0.005 ppm (0.034 mg/m3), JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 0.005 ppm (0.035 mg/m3), JAN1999
Occupational Exposure Limit - FRANCE VME 0.01 ppm (0.075 mg/m3), VLE 0.02 ppm (0.15 mg/m3), JAN1999
Occupational Exposure Limit - GERMANY MAK 0.01 ppm (0.07 mg/m3), JAN1999
Occupational Exposure Limit - HUNGARY time-weighted average 0.05 mg/m3, short term exposure limit 0.1 mg/m3, JAN1993
Occupational Exposure Limit - JAPAN Occupational Exposure Limit 0.005 ppm (0.034 mg/m3), JAN1999
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 0.04 mg/m3, 2003
Occupational Exposure Limit - POLAND MAC(time-weighted average) 0.05 mg/m3, short term exposure limit 0.15 mg/m3, JAN1999
Occupational Exposure Limit - RUSSIA short term exposure limit 0.05 mg/m3, Skin, JAN1993
Occupational Exposure Limit - SWEDEN NGV 0.005 ppm (0.03 mg/m3), TGV 0.01 ppm (0.07 mg/m3), JAN1999
Occupational Exposure Limit - SWITZERLAND MAK- week 0.01 ppm (0.07 mg/m3), KZG- week 0.02 ppm (0.14 mg/m3), JAN1999
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 0.02 mg(NCO)/m3, short term exposure limit 0.07 mg(NCO)/m3, SEP2000
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 0.005 ppm
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 0.005 ppm


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO HDI-air 10 hour time-weighted average 0.035 mg/m3;
ceiling concentration 0.14 mg/m3/10 minute 		NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: M4839;
Number of Industries 9;
Total Number of Facilities 238;
Number of Occupations 12;
Total Number of Employees Exposed 4,490
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: M4839;
Number of Industries 21;
Total Number of Facilities 1,895;
Number of Occupations 26;
Total Number of Employees Exposed 19,180;
Total Number of Female Employees Exposed 329


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
ATSDR TOXICOLOGY PROFILE (NTIS** PB/99/102543/AS)
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Isocyanates, monomeric, 5521
NIOSH Analytical Method, 1996: Isocyanates, 5522
OSHA ANALYTICAL METHOD #42


REFERENCES:

CODEN
REFERENCE
85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958-
CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
REPTED Reproductive Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987-
TAKHAA Takeda Kenkyusho Ho. Journal of the Takeda Research Laboratories. (Takeda Yakuhin Kogyo K.K., 2-17-85 Jusohon-machi, Yodogawa-ku, Osaka 532, Japan) V.29- 1970-
TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968-
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
TOSCF2 Toxicological Sciences (Oxford University Press, 6277 Sea Harbor Drive, Orlando, FL 32887 ) V. 41, Jan. 1998-

RTECS Compound Description:
   Agricultural Chemical

ALT CAS #: 66368-96-5
Click Here for Additional Information about RTECS