The Registry of Toxic Effects of Chemical Substances

1,6 - Hexanediamine

RTECS #: MO1180000

CAS #: 124-09-4

UPDATE: November 2004 MW: 116.24 MF: C6H16N2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. REPRODUCTIVE EFFECTS DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. 1,6 - Diaminohexane
  2. Hexamethylenediamine
  3. 1,6 - Hexamethylenediamine
  1. 1,6 - Hexanediamine (ACGIH)
  2. HMDA
  3. NCI - C61405


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lowest published toxic dose: 414 mg/kg (10 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system 		TJADAB 28,237,1983
oral
rat 		lowest published toxic dose: 3 gm/kg (6-15 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Hepatobiliary system 		JJATDK 7,259,1987
oral
rat 		lowest published toxic dose: 1,840 mg/kg (6-15 day pregnant) Reproductive: Specific developmental abnormalities: Urogenital system JJATDK 7,259,1987
oral
rat 		lowest published toxic dose: 77 gm/kg (multigeneration) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) FAATDF 16,490,1991
oral
rat 		lowest published toxic dose: 66,500 mg/kg (multigeneration) Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth) FAATDF 16,490,1991


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mouse 		lowest published lethal concentration: 750 mg/m3/10 minute N/R NDRC** NDCrc-132,SEP1942
inhalation
rat 		lethal concentration : >950 mg/m3/4 hour N/R EPASR* 8EHQ-1090-0979
intraperitoneal
mouse 		lethal dose (50 percent kill): 320 mg/kg N/R GISAAA 43(11),110,1978
intravenous
mouse 		lethal dose (50 percent kill): 180 mg/kg N/R CSLNX* NX#02313
oral
rat 		lethal dose (50 percent kill): 750 mg/kg N/R TXAPA9 42,417,1977
subcutaneous
mouse 		lethal dose (50 percent kill): 1,300 mg/kg N/R 85GMAT -,74,1982
skin
rabbit 		lethal dose (50 percent kill): 1,110 mg/kg N/R TXAPA9 42,417,1977


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published toxic concentration: 5 gm/m3/6 hour/2 week- intermittent Lung, Thorax, or Respiration: Other changes

Blood: Hemorrhage

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		BJIMAG 27,1,1970
inhalation
rat 		lowest published toxic concentration: 215 mg/m3/6 hour/13 week- intermittent Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		FAATDF 9,504,1987
inhalation
rat 		lowest published toxic concentration: 360 µg/m3/17 week- intermittent Cardiac: Other changes

Vascular: Other changes 		GISAAA 23(11),71,1958


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.5 ppm DTLVS* TLV/BEI,2003


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Exposure Limit - HUNGARY time-weighted average 1 mg/m3, short term exposure limit 2 mg/m3, Skin, JAN1993
Occupational Exposure Limit - RUSSIA short term exposure limit 0.1 mg/m3, JAN1993
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 2.3 mg/m3, 2003


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 83335;
Number of Industries 4;
Total Number of Facilities 62;
Number of Occupations 9;
Total Number of Employees Exposed 1,093
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 83335;
Number of Industries 9;
Total Number of Facilities 879;
Number of Occupations 24;
Total Number of Employees Exposed 31,036;
Total Number of Female Employees Exposed 4,686


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as textile intermediate, wet strength resins, boiler feed water additives and adhesives
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982
BJIMAG British Journal of Industrial Medicine. (British Medical Journal, Box 560B, Kennebunkport, ME 04046) V.1- 1944-
CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
EPASR* United States Environmental Protection Agency, Office of Pesticides and Toxic Substances. (U.S. Environmental Protection Agency, 401 M St., SW, Washington, DC 20460) History unknown.
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information, see TOSCF2
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
JJATDK JAT, Journal of Applied Toxicology. (John Wiley & Sons Ltd., Baffins Lane, Chichester, W. Sussex PO19 1UD, UK) V.1- 1981-
NDRC** National Defense Research Committee, Office of Scientific Research and Development, Progress Report.
TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-

Used as textile intermediate, wet strength resins, boiler feed water additives and adhesives

NIOSH PROFILE (AMINES, PRIMARY ALIPHATIC), SRI, 2/77

NIOSH PROFILE (AMINES, POLY), SRI, 2/77

RTECS Compound Description:
   Reproductive Effector

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