The Registry of Toxic Effects of Chemical Substances

Heptyl alcohol

RTECS #: MK0350000

CAS #: 111-70-6

UPDATE: February 2003 MW: 116.23 MF: C7H16O


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. STANDARDS AND REGULATIONS:
  6. NIOSH DOCUMENTATION AND SURVEILLANCE:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. l'Alcool N - heptylique primaire (French)
  2. Enanthic alcohol
  3. n - Heptanol
  1. 1 - Heptanol
  2. N - Heptanol - 1 (French)
  3. 1 - Hydroxyheptane


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
sex chromosome loss and nondisjunction hamster lung 2 mmol/L MUREAV 182,135,1987


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mammal (species unspecified) 		lethal concentration (50 percent kill): 6,600 mg/m3 N/R GISAAA 51(5),61,1986
inhalation
mouse 		lethal concentration (50 percent kill): 6,600 mg/m3/2 hour N/R 85GMAT -,72,1982
inhalation
mouse 		lethal concentration (50 percent kill): 6,600 mg/m3 Behavioral: Ataxia

Behavioral: Irritability

Lung, Thorax, or Respiration: Dyspnea 		VCVGK* -,113,1984
intraperitoneal
rat 		lowest published toxic dose: 256 mg/kg Behavioral: Ataxia

Behavioral: Irritability

Lung, Thorax, or Respiration: Dyspnea 		VCVGK* -,113,1984
oral
mouse 		lethal dose (50 percent kill): 1,500 mg/kg N/R GISAAA 31,16,1966
oral
mouse 		lethal dose (50 percent kill): 6,000 mg/kg Behavioral: Ataxia

Behavioral: Irritability

Lung, Thorax, or Respiration: Dyspnea 		VCVGK* -,113,1984
oral
rat 		lethal dose (50 percent kill): 500 mg/kg Lung, Thorax, or Respiration: Acute pulmonary edema AMPMAR 35,501,1974
oral
rat 		lethal dose (50 percent kill): 3,800 mg/kg Behavioral: Ataxia

Behavioral: Irritability

Lung, Thorax, or Respiration: Dyspnea 		VCVGK* -,113,1984
oral
rabbit 		lethal dose (50 percent kill): 750 mg/kg N/R HYSAAV 31(1-3),310,1966
skin
rabbit 		lethal dose (50 percent kill): 2 gm/kg Lung, Thorax, or Respiration: Acute pulmonary edema AMPMAR 35,501,1974
unreported route
mammal (species unspecified) 		lethal dose (50 percent kill): 4,350 mg/kg N/R GISAAA 51(5),61,1986


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mammal (species unspecified) 		lowest published toxic concentration: 180 mg/m3/2 hour/137 day- intermittent Lung, Thorax, or Respiration: Other changes

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes 		VCVGK* -,113,1994
inhalation
mammal (species unspecified) 		lowest published toxic concentration: 32 mg/m3/26 week- intermittent Brain and Coverings: Recordings from specific areas of CNS

Eye: Optic nerve neuropathy

Eye: Other eye effects 		VCVGK* -,113,1994
inhalation
rat 		lowest published toxic concentration: 350 mg/m3/19 week- intermittent Brain and Coverings: Other degenerative changes

Cardiac: Other changes

Lung, Thorax, or Respiration: Other changes 		NTIS** PB234-882
oral
rabbit 		lowest published toxic dose: 9,100 mg/kg/26 week- intermittent Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase GISAAA 31(3),16,1966
oral
rabbit 		lowest published toxic dose: 4.56 mg/kg/26 week- intermittent Brain and Coverings: Other degenerative changes

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes 		VCVGK* -,113,1994


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Exposure Limit - RUSSIA short term exposure limit 10 mg/m3, Skin, JAN1993


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 83568;
Number of Industries 2;
Total Number of Facilities 44;
Number of Occupations 6;
Total Number of Employees Exposed 1,105
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 83568;
Number of Industries 1;
Total Number of Facilities 3;
Number of Occupations 1;
Total Number of Employees Exposed 17


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982
AMPMAR Archives des Maladies Professionnelles de Medecine du Travail et de Securite Sociale. (SPPIF, B.P.22, F-41353 Vineuil, France) V.7- 1946-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
HYSAAV Hygiene and Sanitation (USSR). English translation of GISAAA. (Springfield, VA) 1964-71. Discontinued.
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
VCVGK* "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994.

RTECS Compound Description:
   Mutagen

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