The Registry of Toxic Effects of Chemical Substances

4 - Heptanone, 2,6 - dimethyl -

RTECS #: MJ5775000

CAS #: 108-83-8

UPDATE: November 2004 MW: 142.27 MF: C9H18O


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. 2,6 - Dimethyl - 4 - heptanone
  2. 2,6 - Dimethyl - 4 - heptanone (OSHA)
  3. 2,6 - Dimethyl - heptan - 4 - on (Dutch,German)
  4. 2,6 - Dimethylheptan - 4 - one
  5. 2,6 - Dimetil - eptan - 4 - one (Italian)
  6. Di - isobutylcetone (French)
  7. Diisobutilchetone (Italian)
  8. Diisobutyl ketone
  1. Diisobutyl ketone (ACGIH:OSHA)
  2. Diisobutylketon (Dutch, German)
  3. Isobutyl ketone
  4. Isovalerone
  5. Valerone
  6. s - Diisopropylacetone
  7. sym - Diisopropylacetone


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
human 		25 ppm/15 minute mild JIHTAB 28,262,1946
eye
rabbit 		500 mg mild AJOPAA 29,1363,1946
skin
rabbit 		10 mg/24 hour open irritation test mild JIHTAB 31,60,1949
skin
rabbit 		500 mg open irritation test mild UCDS** 12/15/1971


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
human 		lowest published toxic concentration: 50 ppm Eye: Other eye effects

Behavioral: Headache

Gastrointestinal: Nausea or vomiting 		NPIRI* 1,23,1974
inhalation
mouse 		lowest published toxic concentration: 1,813 mg/m3/4 hour Behavioral: Alteration of classical conditioning VCVGK* -,432,1994
inhalation
rat 		lowest published lethal concentration: 2,000 ppm/4 hour N/R JIHTAB 31,343,1949
inhalation
rat 		lethal concentration : 11,620 mg/m3/8 hour N/R VCVGK* -,432,1994
oral
mouse 		lethal dose (50 percent kill): 1,416 mg/kg N/R SCCUR* -,4,1961
oral
rat 		lethal dose (50 percent kill): 5,750 mg/kg N/R NPIRI* 1,23,1974
skin
rabbit 		lethal dose (50 percent kill): 16 gm/kg N/R NPIRI* 1,23,1974


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
guinea pig 		lowest published toxic concentration: 250 ppm/7 hour/6 week- intermittent Liver: Changes in liver weight AMIHBC 8,377,1953
inhalation
guinea pig 		lowest published toxic concentration: 9,590 mg/m3/7 hour/30 day- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field VCVGK* -,432,1994
inhalation
guinea pig 		lowest published toxic concentration: 1,450 mg/m3/7 hour/30 day- intermittent Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in kidney weight 		VCVGK* -,432,1994
inhalation
rat 		lowest published toxic concentration: 98 ppm/6 hour/9 day- intermittent Behavioral: Fluid intake

Kidney, Ureter, and Bladder: Urine volume increased

Kidney, Ureter, and Bladder: Other changes in urine composition 		TIHEEC 3,443,1987
inhalation
rat 		lowest published toxic concentration: 250 ppm/7 hour/6 week- intermittent Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in bladder weight 		AMIHBC 8,377,1953
inhalation
rat 		lowest published toxic concentration: 9,590 mg/m3/7 hour/30 day- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field VCVGK* -,432,1994
inhalation
rat 		lowest published toxic concentration: 1,450 mg/m3/7 hour/30 day- intermittent Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in kidney weight 		VCVGK* -,432,1994
oral
rat 		lowest published toxic dose: 30 gm/kg/3 week- intermittent Behavioral: Somnolence (general depressed activity)

Liver: Changes in liver weight 		NTIS** OTS0571116
oral
rat 		lowest published toxic dose: 130 gm/kg/13 week- intermittent Liver: Changes in liver weight

Endocrine: Hypoglycemia

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		NTIS** OTS0571116


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 25 ppm DTLVS* TLV/BEI,2003


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Cancelled RBREV* -,322,1998
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 25 ppm (150 mg/m3) DTLWS* 3,16,1973
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 50 ppm (290 mg/m3) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 50 ppm (290 mg/m3) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 50 ppm (290 mg/m3) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 50 ppm (290 mg/m3) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 25 ppm (150 mg/m3), JAN1993
Occupational Exposure Limit - AUSTRIA MAK 50 ppm (290 mg/m3), JAN1999
Occupational Exposure Limit - BELGIUM time-weighted average 25 ppm (145 mg/m3), JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 25 ppm (150 mg/m3), JAN1999
Occupational Exposure Limit - FINLAND time-weighted average 25 ppm (150 mg/m3), short term exposure limit 40 ppm (225 mg/m3), JAN1999
Occupational Exposure Limit - FRANCE VME 25 ppm (150 mg/m3), JAN1999
Occupational Exposure Limit - GERMANY MAK 50 ppm (290 mg/m3), JAN1999
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 150 mg/m3, 2003
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 50 ppm (290 mg/m3), JAN1993
Occupational Exposure Limit - POLAND MAC(time-weighted average) 150 mg/m3, MAC(short term exposure limit) 300 mg/m3, JAN1999
Occupational Exposure Limit - SWITZERLAND MAK- week 25 ppm (150 mg/m3), JAN1999
Occupational Exposure Limit - TURKEY time-weighted average 50 ppm (290 mg/m3), JAN1993
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 25 ppm (148 mg/m3), SEP2000
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 25 ppm
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 25 ppm


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO DIISOBUTYL KETONE-air 10 hour time-weighted average 25 ppm NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 25820;
Number of Industries 56;
Total Number of Facilities 7,290;
Number of Occupations 49;
Total Number of Employees Exposed 55,554
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 25820;
Number of Industries 66;
Total Number of Facilities 6,204;
Number of Occupations 59;
Total Number of Employees Exposed 72,926;
Total Number of Female Employees Exposed 14,857


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Ketones I, 1300


REFERENCES:

CODEN
REFERENCE
AJOPAA American Journal of Ophthalmology. (Ophthalmic Pub. Co., 435 N. Michigan Ave., Suite 1415, Chicago, IL 60611) Series 3: V.1- 1918-
AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine. (Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU.
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
DTLWS* "Documentation of the Threshold Limit Values for Substances in Workroom Air," Supplements. For publisher information, see 85INA8.
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU.
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NPIRI* Raw Material Data Handbook, Vol.1: Organic Solvents, 1974. (National Assoc. of Printing Ink Research Institute, Francis McDonald Sinclair Memorial Laboratory, Lehigh Univ., Bethlehem, PA 18015)
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
SCCUR* Shell Chemical Company. Unpublished Report. (2401 Crow Canyon Rd., San Romon, CA 94583)
TIHEEC Toxicology and Industrial Health. (Princeton Scientific Pub. Co., POB 2155, Princeton, NJ 08540) V.1- 1985-
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817)
VCVGK* "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994.

RTECS Compound Description:
   Human Data
   Primary Irritant

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